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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities:    
Net loss $ (26,694) $ (29,582)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of (discount)/premium on available-for-sale securities (21) (148)
Equity-based compensation expense 3,104 3,500
Depreciation expense 1,026 596
Changes in operating assets and liabilities:    
Prepaid expenses and other current and non-current assets (1,205) (707)
Accounts payable (4,309) 1,666
Accrued expenses and other current and non-current liabilities (1,175) (1,252)
Net cash used in operating activities (29,274) (25,927)
Cash flows from investing activities:    
Purchases of property and equipment (681) (1,953)
Proceeds from sale and maturities of available-for-sale securities 7,500 10,924
Purchases of marketable investments (401) (15,416)
Net cash provided by (used in) investing activities 6,418 (6,445)
Cash flows from financing activities:    
Net decrease in cash, cash equivalents and restricted cash (22,856) (32,372)
Cash, cash equivalents, and restricted cash at beginning of period 76,370 86,693
Cash, cash equivalents, and restricted cash at end of period 53,514 54,321
Supplemental disclosure of non-cash investing and financing activities:    
Operating lease liabilities arising from obtaining right-of-use asset   1,629
Property and equipment included in accounts payable and accruals $ 55 $ 1,043