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Nature of the Business and Basis of Presentation - Additional Information (Detail)
$ in Thousands
 3 Months Ended
Dec. 02, 2022
USD ($)
shares
Oct. 27, 2022
shares
Mar. 31, 2023
USD ($)
shares
Mar. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
shares
Oct. 28, 2022
shares
Jun. 30, 2022
shares
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Net loss     $ 30,070 $ 25,328      
Accumulated deficit     592,808   $ 562,738    
Net cash used in operating activities     27,995 $ 27,190      
Cash, cash equivalents and available-for-sale securities     $ 185,509        
Reverse stock split of outstanding shares of common stock   one-for-15          
Stockholders' equity note, stock split, conversion ratio   0.015          
Common stock, shares authorized | shares   20,000,000 60,000,000   60,000,000 60,000,000 300,000,000
Restricted cash     $ 1,833        
Securities Purchase Agreement [Member]              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Net proceeds from private placement $ 72,551            
Common Stock [Member] | Securities Purchase Agreement [Member]              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Common stock shares issued | shares 10,638,290