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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Pay vs Performance Disclosure |  |  |
Pay vs Performance Disclosure, Table | Pay Versus Performance Disclosure In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officers (“ PEOs ”) and other named executive officers (the “ Non-PEO NEOs ”) and Company performance for the fiscal years listed below. The compensation committee did not consider the pay versus performance disclosure below in making its compensation decisions for any of the years shown.
Year |  | Summary Compensation Table Total for First PEO¹ ($) |  |  | Summary Compensation Table Total for Second PEO¹ |  |  | Compensation Actually Paid to First PEO 1,2,3 ($) |  |  | Compensation Actually Paid to Second PEO 1,2,3 ($) |  |  | Average Summary Compensation Table Total for Non-PEO NEOs 1 ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs 1,2,3 ($) |  |  | Value of Initial Fixed $100 Investment based on Total Shareholder Return 4 ($) |  |  | Net Income ($ Millions) |
2024 |  |  | — |  |  |  | 4,869,909 |  |  |  | — |  |  |  | 3,451,845 |  |  |  | 2,317,193 |  |  |  | 1,646,659 |  |  |  | 15.24 |  |  |  | (124.70 | )
2023 |  |  | — |  |  |  | 918,630 |  |  |  | — |  |  |  | 862,406 |  |  |  | 1,184,878 |  |  |  | 1,051,672 |  |  |  | 23.39 |  |  |  | (96.02 | )
2022 |  |  | 2,205,508 |  |  |  | 2,200,212 |  |  |  | 1,704,198 |  |  |  | 1,627,647 |  |  |  | 1,077,118 |  |  |  | 825,433 |  |  |  | 20.50 |  |  |  | (85.98 | )
1. | Ilan Ganot was our PEO until December 2, 2022 (“ First PEO ”). Alexander Cumbo has been our PEO since December 2, 2022 (“ Second PEO ”). The individuals comprising the Non-PEO NEOs for each year presented are listed below.
2022 |  | 2023 |  | 2024
Carl Morris, Ph.D. |  | Kevin Tan |  | Gabriel Brooks, M.D.
David Tyronne Howton |  | Carl Morris, Ph.D. |  | David Tyronne Howton
Erin Powers Brennan |  | David Tyronne Howton |  |
2. | The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect the actual amount of compensation actually earned, realized, or received by the Company’s NEOs during the applicable years. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the Non-PEO NEOs are averages for the group of Non-PEO NEOs in each applicable year).
Year |  | Summary Compensation Table Total for Second PEO ($) |  |  | Exclusion of Stock Awards and Option Awards for Second PEO ($) |  |  | Inclusion of Equity Values for Second PEO ($) |  |  | Compensation Actually Paid to Second PEO ($) |
2024 |  |  | 4,869,909 |  |  |  | (3,914,469 | ) |  |  | 2,496,405 |  |  |  | 3,451,845 |
Year |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2024 |  |  | 2,317,193 |  |  |  | (1,646,190 | ) |  |  | 975,656 |  |  |  | 1,646,659 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Second PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Second PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Second PEO ($) |  |  | Total - Inclusion of Equity Values for Second PEO ($) |
2024 |  |  | 2,688,549 |  |  |  | (265,855 | ) |  |  | — |  |  |  | 73,711 |  |  |  | — |  |  |  | 2,496,405 |
Year |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Non-PEO NEOs ($) |  |  | Average Vesting- Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
2024 |  |  | 1,121,611 |  |  |  | (160,324 | ) |  |  | — |  |  |  | 14,369 |  |  |  | — |  |  |  | 975,656 |
4. | The amounts shown assume $100 was invested for the period starting December 31, 2021, through the end of the listed year in the Company. Historical stock performance is not necessarily indicative of future stock performance.
Named Executive Officers, Footnote |
1. | Ilan Ganot was our PEO until December 2, 2022 (“ First PEO ”). Alexander Cumbo has been our PEO since December 2, 2022 (“ Second PEO ”). The individuals comprising the Non-PEO NEOs for each year presented are listed below.
2022 |  | 2023 |  | 2024
Carl Morris, Ph.D. |  | Kevin Tan |  | Gabriel Brooks, M.D.
David Tyronne Howton |  | Carl Morris, Ph.D. |  | David Tyronne Howton
Erin Powers Brennan |  | David Tyronne Howton |  |
Adjustment To PEO Compensation, Footnote |
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the Non-PEO NEOs are averages for the group of Non-PEO NEOs in each applicable year).
Year |  | Summary Compensation Table Total for Second PEO ($) |  |  | Exclusion of Stock Awards and Option Awards for Second PEO ($) |  |  | Inclusion of Equity Values for Second PEO ($) |  |  | Compensation Actually Paid to Second PEO ($) |
2024 |  |  | 4,869,909 |  |  |  | (3,914,469 | ) |  |  | 2,496,405 |  |  |  | 3,451,845 |
Year |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2024 |  |  | 2,317,193 |  |  |  | (1,646,190 | ) |  |  | 975,656 |  |  |  | 1,646,659 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Second PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Second PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Second PEO ($) |  |  | Total - Inclusion of Equity Values for Second PEO ($) |
2024 |  |  | 2,688,549 |  |  |  | (265,855 | ) |  |  | — |  |  |  | 73,711 |  |  |  | — |  |  |  | 2,496,405 |
Year |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Non-PEO NEOs ($) |  |  | Average Vesting- Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
2024 |  |  | 1,121,611 |  |  |  | (160,324 | ) |  |  | — |  |  |  | 14,369 |  |  |  | — |  |  |  | 975,656 |
Non-PEO NEO Average Total Compensation Amount | $ 2,317,193 | $ 1,184,878 | $ 1,077,118
Non-PEO NEO Average Compensation Actually Paid Amount | $ 1,646,659 | 1,051,672 | 825,433
Adjustment to Non-PEO NEO Compensation Footnote |
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the Non-PEO NEOs are averages for the group of Non-PEO NEOs in each applicable year).
Year |  | Summary Compensation Table Total for Second PEO ($) |  |  | Exclusion of Stock Awards and Option Awards for Second PEO ($) |  |  | Inclusion of Equity Values for Second PEO ($) |  |  | Compensation Actually Paid to Second PEO ($) |
2024 |  |  | 4,869,909 |  |  |  | (3,914,469 | ) |  |  | 2,496,405 |  |  |  | 3,451,845 |
Year |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2024 |  |  | 2,317,193 |  |  |  | (1,646,190 | ) |  |  | 975,656 |  |  |  | 1,646,659 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Second PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Second PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Second PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Second PEO ($) |  |  | Total - Inclusion of Equity Values for Second PEO ($) |
2024 |  |  | 2,688,549 |  |  |  | (265,855 | ) |  |  | — |  |  |  | 73,711 |  |  |  | — |  |  |  | 2,496,405 |
Year |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year for Non-PEO NEOs ($) |  |  | Average Vesting- Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
2024 |  |  | 1,121,611 |  |  |  | (160,324 | ) |  |  | — |  |  |  | 14,369 |  |  |  | — |  |  |  | 975,656 |
Compensation Actually Paid vs. Total Shareholder Return | Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Company Total Shareholder Return (“TSR”) The following chart sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our Non-PEO NEOs and the Company’s cumulative TSR over the three most recently completed fiscal years. |  |
Compensation Actually Paid vs. Net Income | Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net (Loss) Income The following chart sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our Non-PEO NEOs, and our Net (Loss) Income during the three most recently completed fiscal years. |  |
Total Shareholder Return Amount | $ 15.24 | 23.39 | 20.5
Net Income (Loss) | (124,700,000) | (96,020,000.00) | (85,980,000)
Ilan Ganot [Member] |  |  |
Pay vs Performance Disclosure |  |  |
PEO Total Compensation Amount | 0 | 0 | 2,205,508
PEO Actually Paid Compensation Amount | $ 0 | 0 | 1,704,198
PEO Name | Ilan Ganot |  |
Alexander Cumbo [Member] |  |  |
Pay vs Performance Disclosure |  |  |
PEO Total Compensation Amount | $ 4,869,909 | 918,630 | 2,200,212
PEO Actually Paid Compensation Amount | $ 3,451,845 | $ 862,406 | $ 1,627,647
PEO Name | Alexander Cumbo |  |
PEO | Alexander Cumbo [Member] | Equity Awards Adjustments |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ 2,496,405 |  |
PEO | Alexander Cumbo [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 2,688,549 |  |
PEO | Alexander Cumbo [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (265,855) |  |
PEO | Alexander Cumbo [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Alexander Cumbo [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 73,711 |  |
PEO | Alexander Cumbo [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
PEO | Alexander Cumbo [Member] | Exclusion of Stock Awards and Option Awards for Second PEO [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (3,914,469) |  |
Non-PEO NEO | Equity Awards Adjustments |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 975,656 |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 1,121,611 |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | (160,324) |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 14,369 |  |
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | 0 |  |
Non-PEO NEO | Exclusion of Stock Awards and Option Awards for Second PEO [Member] |  |  |
Pay vs Performance Disclosure |  |  |
Adjustment to Compensation, Amount | $ (1,646,190) |  |

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