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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Pay Versus Performance Disclosure
In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officers (“
PEOs
”) and other named executive officers (the “
Non-PEO
NEOs
”) and Company performance for the fiscal years listed below. The compensation committee did not consider the pay versus performance disclosure below in making its compensation decisions for any of the years shown.
 
Year
  
Summary
Compensation
Table
Total for
First PEO¹
($)
    
Summary
Compensation
Table
Total for
Second
PEO¹
    
Compensation
Actually
Paid to
First
PEO
1,2,3

($)
    
Compensation
Actually
Paid to
Second
PEO
1,2,3

($)
    
Average
Summary
Compensation
Table
Total for
Non-PEO

NEOs
1

($)
    
Average
Compensation
Actually
Paid to
Non-PEO

NEOs
1,2,3

($)
    
Value of
Initial
Fixed
$100
Investment
based on
Total
Shareholder
Return
4

($)
    
Net
Income
($ Millions)
  
2024
     —        4,869,909       —        3,451,845       2,317,193       1,646,659       15.24       (124.70 ) 
2023
     —        918,630       —        862,406       1,184,878       1,051,672       23.39       (96.02 ) 
2022
     2,205,508       2,200,212       1,704,198       1,627,647       1,077,118       825,433       20.50       (85.98 ) 
 
1.
Ilan Ganot was our PEO until December 2, 2022 (“
First PEO
”). Alexander Cumbo has been our PEO since December 2, 2022 (“
Second PEO
”). The individuals comprising
the Non-PEO NEOs
for each year presented are listed below.
 
2022
   
2023
   
2024
Carl Morris, Ph.D.
    Kevin Tan    Gabriel Brooks, M.D.
David Tyronne Howton
    Carl Morris, Ph.D.    David Tyronne Howton
Erin Powers Brennan
    David Tyronne Howton   
 
2.
The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation
S-K
and do not reflect the actual amount of compensation actually earned, realized, or received by the Company’s NEOs during the applicable years. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
3.
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the
Non-PEO
NEOs are averages for the group of
Non-PEO
NEOs in each applicable year).
 
Year
   
Summary
Compensation
Table Total
for Second
PEO
($)
     
Exclusion of
Stock Awards
and Option
Awards for
Second PEO
($)
     
Inclusion of
Equity Values
for Second PEO
($)
     
Compensation
Actually Paid to
Second PEO
($)
  
2024
      4,869,909        (3,914,469 )       2,496,405        3,451,845  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
and Option
Awards for
Non-PEO NEOs

($)
     
Average
Inclusion of
Equity Values
for Non-PEO

NEOs
($)
     
Average
Compensation
Actually Paid to
Non-PEO NEOs

($)
  
2024
      2,317,193        (1,646,190 )       975,656        1,646,659  
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last Day
of Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and
Unvested
Equity
Awards
Granted in
any Prior
Year for
Second PEO
($)
    
Vesting-Date
Fair
Value of
Equity
Awards
Granted
During
Year that
Vested
During
Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of
Prior Year
to Vesting
Date of
Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During
Year for
Second
PEO
($)
     
Fair Value at
Last Day of
Prior Year
of Equity
Awards
Forfeited
During
Year
for Second
PEO
($)
     
Total -
Inclusion of
Equity
Values for
Second PEO
($)
  
2024
      2,688,549        (265,855 )      —         73,711        —         2,496,405  
 
Year
   
Average
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last
Day of Year
for Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and Unvested
Equity
Awards
Granted in
any Prior
Year for
Non-PEO

NEOs
($)
     
Average
Vesting-
Date Fair Value
of Equity
Awards
Granted
During Year
that Vested
During Year for
Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting Date
of Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During Year
for Non-PEO

NEOs
($)
     
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-PEO

NEOs
($)
     
Total -
Average
Inclusion of
Equity
Values for
Non-PEO

NEOs
($)
  
2024
      1,121,611        (160,324 )       —         14,369        —         975,656  
 
4.
The amounts shown assume $100 was invested for the period starting December 31, 2021, through the end of the listed year in the Company. Historical stock performance is not necessarily indicative of future stock performance.
   
Named Executive Officers, Footnote
1.
Ilan Ganot was our PEO until December 2, 2022 (“
First PEO
”). Alexander Cumbo has been our PEO since December 2, 2022 (“
Second PEO
”). The individuals comprising
the Non-PEO NEOs
for each year presented are listed below.
 
2022
   
2023
   
2024
Carl Morris, Ph.D.
    Kevin Tan    Gabriel Brooks, M.D.
David Tyronne Howton
    Carl Morris, Ph.D.    David Tyronne Howton
Erin Powers Brennan
    David Tyronne Howton   
   
Adjustment To PEO Compensation, Footnote
3.
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the
Non-PEO
NEOs are averages for the group of
Non-PEO
NEOs in each applicable year).
 
Year
   
Summary
Compensation
Table Total
for Second
PEO
($)
     
Exclusion of
Stock Awards
and Option
Awards for
Second PEO
($)
     
Inclusion of
Equity Values
for Second PEO
($)
     
Compensation
Actually Paid to
Second PEO
($)
  
2024
      4,869,909        (3,914,469 )       2,496,405        3,451,845  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
and Option
Awards for
Non-PEO NEOs

($)
     
Average
Inclusion of
Equity Values
for Non-PEO

NEOs
($)
     
Average
Compensation
Actually Paid to
Non-PEO NEOs

($)
  
2024
      2,317,193        (1,646,190 )       975,656        1,646,659  
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last Day
of Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and
Unvested
Equity
Awards
Granted in
any Prior
Year for
Second PEO
($)
    
Vesting-Date
Fair
Value of
Equity
Awards
Granted
During
Year that
Vested
During
Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of
Prior Year
to Vesting
Date of
Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During
Year for
Second
PEO
($)
     
Fair Value at
Last Day of
Prior Year
of Equity
Awards
Forfeited
During
Year
for Second
PEO
($)
     
Total -
Inclusion of
Equity
Values for
Second PEO
($)
  
2024
      2,688,549        (265,855 )      —         73,711        —         2,496,405  
 
Year
   
Average
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last
Day of Year
for Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and Unvested
Equity
Awards
Granted in
any Prior
Year for
Non-PEO

NEOs
($)
     
Average
Vesting-
Date Fair Value
of Equity
Awards
Granted
During Year
that Vested
During Year for
Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting Date
of Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During Year
for Non-PEO

NEOs
($)
     
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-PEO

NEOs
($)
     
Total -
Average
Inclusion of
Equity
Values for
Non-PEO

NEOs
($)
  
2024
      1,121,611        (160,324 )       —         14,369        —         975,656  
    
Non-PEO NEO Average Total Compensation Amount $ 2,317,193 $ 1,184,878 $ 1,077,118
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,646,659 1,051,672 825,433
Adjustment to Non-PEO NEO Compensation Footnote
3.
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table (the amounts for the
Non-PEO
NEOs are averages for the group of
Non-PEO
NEOs in each applicable year).
 
Year
   
Summary
Compensation
Table Total
for Second
PEO
($)
     
Exclusion of
Stock Awards
and Option
Awards for
Second PEO
($)
     
Inclusion of
Equity Values
for Second PEO
($)
     
Compensation
Actually Paid to
Second PEO
($)
  
2024
      4,869,909        (3,914,469 )       2,496,405        3,451,845  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
and Option
Awards for
Non-PEO NEOs

($)
     
Average
Inclusion of
Equity Values
for Non-PEO

NEOs
($)
     
Average
Compensation
Actually Paid to
Non-PEO NEOs

($)
  
2024
      2,317,193        (1,646,190 )       975,656        1,646,659  
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last Day
of Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and
Unvested
Equity
Awards
Granted in
any Prior
Year for
Second PEO
($)
    
Vesting-Date
Fair
Value of
Equity
Awards
Granted
During
Year that
Vested
During
Year for
Second PEO
($)
     
Change in
Fair Value
from Last
Day of
Prior Year
to Vesting
Date of
Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During
Year for
Second
PEO
($)
     
Fair Value at
Last Day of
Prior Year
of Equity
Awards
Forfeited
During
Year
for Second
PEO
($)
     
Total -
Inclusion of
Equity
Values for
Second PEO
($)
  
2024
      2,688,549        (265,855 )      —         73,711        —         2,496,405  
 
Year
   
Average
Year-End

Fair Value of
Equity
Awards
Granted
During Year
That
Remained
Outstanding
and Unvested
as of Last
Day of Year
for Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of
Outstanding
and Unvested
Equity
Awards
Granted in
any Prior
Year for
Non-PEO

NEOs
($)
     
Average
Vesting-
Date Fair Value
of Equity
Awards
Granted
During Year
that Vested
During Year for
Non-PEO

NEOs
($)
     
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting Date
of Unvested
Equity
Awards
Granted in
any Prior
Year that
Vested
During Year
for Non-PEO

NEOs
($)
     
Average Fair
Value at Last
Day of Prior
Year of
Equity
Awards
Forfeited
During Year
for Non-PEO

NEOs
($)
     
Total -
Average
Inclusion of
Equity
Values for
Non-PEO

NEOs
($)
  
2024
      1,121,611        (160,324 )       —         14,369        —         975,656  
    
Compensation Actually Paid vs. Total Shareholder Return
Description of Relationship Between PEO and
Non-PEO
NEO Compensation Actually Paid and Company Total Shareholder Return (“TSR”)
The following chart sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our
Non-PEO
NEOs and the Company’s cumulative TSR over the three most recently completed fiscal years.
 
 
LOGO 		   
Compensation Actually Paid vs. Net Income
Description of Relationship Between PEO and
Non-PEO
NEO Compensation Actually Paid and Net (Loss) Income
The following chart sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and our Net (Loss) Income during the three most recently completed fiscal years.
 
LOGO 		   
Total Shareholder Return Amount $ 15.24 23.39 20.5
Net Income (Loss) (124,700,000) (96,020,000.00) (85,980,000)
Ilan Ganot [Member]      
Pay vs Performance Disclosure      
PEO Total Compensation Amount 0 0 2,205,508
PEO Actually Paid Compensation Amount $ 0 0 1,704,198
PEO Name Ilan Ganot    
Alexander Cumbo [Member]      
Pay vs Performance Disclosure      
PEO Total Compensation Amount $ 4,869,909 918,630 2,200,212
PEO Actually Paid Compensation Amount $ 3,451,845 $ 862,406 $ 1,627,647
PEO Name Alexander Cumbo    
PEO | Alexander Cumbo [Member] | Equity Awards Adjustments      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 2,496,405    
PEO | Alexander Cumbo [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 2,688,549    
PEO | Alexander Cumbo [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (265,855)    
PEO | Alexander Cumbo [Member] | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
PEO | Alexander Cumbo [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 73,711    
PEO | Alexander Cumbo [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
PEO | Alexander Cumbo [Member] | Exclusion of Stock Awards and Option Awards for Second PEO [Member]      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (3,914,469)    
Non-PEO NEO | Equity Awards Adjustments      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 975,656    
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,121,611    
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (160,324)    
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 14,369    
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
Non-PEO NEO | Exclusion of Stock Awards and Option Awards for Second PEO [Member]      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ (1,646,190)