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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 USD ($) | Sep. 30, 2024 USD ($)
Cash flows from operating activities |  |
Net loss | $ (150,394) | $ (199,474)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation | 35,417 | 13,099
Net accretion of discounts on marketable securities | (3,876) | (1,987)
Depreciation and amortization | 2,629 | 2,332
Non-cash lease expense | 1,161 | 31
Loss on disposal of fixed assets |  | 5
Change in fair value of derivative liability |  | 5,406
Gain on bargain purchase in connection with the ACELYRIN Merger | (187,907) |
Impairment of long-lived assets | 529 |
Changes in operating assets and liabilities: |  |
Research and development prepaid expenses | 9,426 | (9,581)
Other prepaid expenses and other assets | 13,346 | (1,605)
Other assets, non-current | (5,073) |
Accounts payable | (11,586) | 5,322
Deferred revenue | 1,944 |
Research and development accrued expenses | 4,935 | 7,193
Other accrued expenses and current liabilities | 2,554 | 426
Operating lease liabilities | (2,328) | (1,481)
Other liabilities, non-current | 168 |
Deferred income tax liability | (8,561) |
Net cash used in operating activities | (297,616) | (180,314)
Cash flows from investing activities |  |
Maturities of marketable securities | 305,423 | 42,000
Purchases of marketable securities | (161,648) | (185,374)
Purchases of property and equipment | (653) | (1,366)
Cash, cash equivalents and restricted cash acquired in connection with the ACELYRIN Merger | 49,742 |
Net cash provided by (used in) investing activities | 192,864 | (144,740)
Cash flows from financing activities |  |
Proceeds from issuance of redeemable convertible preferred stock and derivative liability, net of issuance costs |  | 258,461
Proceeds from initial public offering, net of underwriter discounts and commissions and other offering costs |  | 193,316
Proceeds from a private placement transaction |  | 40,000
Proceeds from issuance of common stock upon exercise of stock options |  | 591
Repurchase of common stock shares issued upon early exercised restricted common stock | (17) | (6)
Proceeds from issuance of common stock under the 2024 ESPP | 766 |
Net cash provided by financing activities | 749 | 492,362
Net (decrease) increase in cash, cash equivalents and restricted cash | (104,003) | 167,308
Cash, cash equivalents and restricted cash at beginning of period | 170,632 | 47,133
Cash, cash equivalents and restricted cash at end of period | 66,629 | 214,441
Supplemental disclosures: |  |
Conversion of 168,489,871 shares of redeemable convertible preferred stock upon the closing of initial public offering |  | 639,237
Equity consideration transferred in connection with the ACELYRIN Merger | 238,077 |
Vesting of early exercised stock options and unvested restricted shares of common stock | 609 | 964
Purchases of property and equipment in other accrued expenses and current liabilities |  | 6
Right-of-use assets obtained in exchange for operating lease liabilities | 1,776 |
Recognition of derivative liability upon issuance of redeemable convertible preferred stock |  | 8,913
Settlement of derivative liability upon issuance of redeemable convertible preferred stock |  | (14,319)
Reconciliation of cash, cash equivalents and restricted cash: |  |
Cash and cash equivalents | 65,257 | 213,417
Restricted cash, non-current | 1,372 | 1,024
Total cash, cash equivalents and restricted cash | $ 66,629 | $ 214,441

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