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v3.25.3

Revenue (Details) $ in Thousands, ¥ in Billions | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Mar. 31, 2025 USD ($) | Sep. 30, 2025 USD ($) | Sep. 30, 2025 USD ($) | Mar. 31, 2025 JPY (¥) | Jan. 31, 2024 USD ($)
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Revenue recognized |  | $ 2,066 | $ 22,121 |  |
Deferred revenue, non-current |  | 1,944 | 1,944 |  |
ACELYRIN |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Development, regulatory and commercial milestone payments |  |  |  |  | $ 157,500
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Upfront, non-refundable payment | $ 20,000 |  |  |  |
Global development cost reimbursement | 20,000 |  |  |  |
Maximum achievement of regulatory milestones | 36,000 |  |  |  |
Maximum achievement of commercial milestones | ¥ |  |  |  | ¥ 15.5 |
Amount allocated to license obligation | 17,400 |  |  |  |
Amount allocated to Development Services Obligation | 20,800 |  |  |  |
Amount allocated to Material Right Obligation | 3,300 |  |  |  |
Deferred revenue, non-current |  | 1,900 | 1,900 |  |
Estimated amount of transaction price unsatisfied |  | 19,400 | 19,400 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Less than |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Collaboration revenue receivable |  | 100 | 100 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | License obligation |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Revenue recognized |  | 0 | 17,400 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Development services obligation |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Estimated amount of transaction price unsatisfied |  | 16,200 | 16,200 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Development services obligation and manufacturing services obligation |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Revenue recognized |  | 2,100 | 4,700 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Material right obligation |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Estimated amount of transaction price unsatisfied |  | $ 3,300 | $ 3,300 |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Global development cost reimbursement in the dermatology field through the end of 2026 |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Global development cost reimbursement | 20,000 |  |  |  |
Kaken | Collaborative Arrangement for Product envu, formerly known as ESK-001 | Estimated global development cost reimbursement in the dermatology field after 2026 |  |  |  |  |
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items] |  |  |  |  |
Global development cost reimbursement | $ 1,500 |  |  |  |

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