<SEC-DOCUMENT>0001415889-25-014561.txt : 20250523
<SEC-HEADER>0001415889-25-014561.hdr.sgml : 20250523
<ACCEPTANCE-DATETIME>20250523204918
ACCESSION NUMBER:		0001415889-25-014561
CONFORMED SUBMISSION TYPE:	SCHEDULE 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250523
DATE AS OF CHANGE:		20250523

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALUMIS INC.
		CENTRAL INDEX KEY:			0001847367
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-94550
		FILM NUMBER:		25983946

	BUSINESS ADDRESS:	
		STREET 1:		280 EAST GRAND AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-231-6625

	MAIL ADDRESS:	
		STREET 1:		280 EAST GRAND AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ESKER THERAPEUTICS, INC.
		DATE OF NAME CHANGE:	20230427

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FL2021-001, Inc.
		DATE OF NAME CHANGE:	20210222

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Samsara BioCapital, L.P.
		CENTRAL INDEX KEY:			0001699737
		ORGANIZATION NAME:           	
		EIN:				813958301
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		628 MIDDLEFIELD ROAD
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
		BUSINESS PHONE:		(650) 285-4270

	MAIL ADDRESS:	
		STREET 1:		628 MIDDLEFIELD ROAD
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94301
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13D/A</submissionType>
		<previousAccessionNumber>0001104659-24-093439</previousAccessionNumber>
	    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001699737</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>





    </filerInfo>
  </headerData>

  <formData>
    <coverPageHeader>
		<amendmentNo>1</amendmentNo>
	      <securitiesClassTitle>Common Stock, $0.0001 par value per share</securitiesClassTitle>
      <dateOfEvent>05/21/2025</dateOfEvent>
	  <previouslyFiledFlag>false</previouslyFiledFlag>
      <issuerInfo>
        <issuerCIK>0001847367</issuerCIK>
        <issuerCUSIP>022307102</issuerCUSIP>
		<issuerName>ALUMIS INC.</issuerName>

        <address>
          <com:street1>280 East Grand Avenue</com:street1>
                    <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </address>
      </issuerInfo>

	  	  <authorizedPersons>

		<notificationInfo>
			<personName>Abrar Hussain</personName>
			<personPhoneNum>(650) 285-4270</personPhoneNum>
				<personAddress>
					<com:street1>Samsara BioCapital GP, LLC</com:street1>
					<com:street2>628 Middlefield Road</com:street2>					<com:city>Palo Alto</com:city>
					<com:stateOrCountry>CA</com:stateOrCountry>
					<com:zipCode>94301</com:zipCode>
				</personAddress>
		</notificationInfo>
			</authorizedPersons>
	    </coverPageHeader>

	<reportingPersons>


			<reportingPersonInfo>
									<reportingPersonCIK>0001699737</reportingPersonCIK>

				<reportingPersonNoCIK>N</reportingPersonNoCIK>
				<reportingPersonName>Samsara BioCapital, L.P. </reportingPersonName>

								<memberOfGroup>b</memberOfGroup>





				  				  <fundType>WC</fundType>



				<legalProceedings>N</legalProceedings>

								<citizenshipOrOrganization>DE</citizenshipOrOrganization>
												<soleVotingPower>0.00</soleVotingPower>
												<sharedVotingPower>4801370.00</sharedVotingPower>
												<soleDispositivePower>0.00</soleDispositivePower>

				<sharedDispositivePower>4801370.00</sharedDispositivePower>
												<aggregateAmountOwned>4801370.00</aggregateAmountOwned>

				<isAggregateExcludeShares>N</isAggregateExcludeShares>

								<percentOfClass>5.0</percentOfClass>






			  			  <typeOfReportingPerson>PN</typeOfReportingPerson>









			</reportingPersonInfo>

			<reportingPersonInfo>
									<reportingPersonCIK>0001888829</reportingPersonCIK>

				<reportingPersonNoCIK>N</reportingPersonNoCIK>
				<reportingPersonName>Samsara BioCapital GP, LLC </reportingPersonName>

								<memberOfGroup>b</memberOfGroup>




				  				  <fundType>AF</fundType>




				<legalProceedings>N</legalProceedings>

								<citizenshipOrOrganization>DE</citizenshipOrOrganization>
												<soleVotingPower>0.00</soleVotingPower>
												<sharedVotingPower>4801370.00</sharedVotingPower>
												<soleDispositivePower>0.00</soleDispositivePower>

				<sharedDispositivePower>4801370.00</sharedDispositivePower>
												<aggregateAmountOwned>4801370.00</aggregateAmountOwned>

				<isAggregateExcludeShares>N</isAggregateExcludeShares>

								<percentOfClass>5.0</percentOfClass>












			  			  <typeOfReportingPerson>OO</typeOfReportingPerson>



			</reportingPersonInfo>

			<reportingPersonInfo>
									<reportingPersonCIK>0001253170</reportingPersonCIK>

				<reportingPersonNoCIK>N</reportingPersonNoCIK>
				<reportingPersonName>Srinivas Akkaraju</reportingPersonName>

								<memberOfGroup>b</memberOfGroup>




				  				  <fundType>AF</fundType>




				<legalProceedings>N</legalProceedings>

								<citizenshipOrOrganization>X1</citizenshipOrOrganization>
												<soleVotingPower>0.00</soleVotingPower>
												<sharedVotingPower>4801370.00</sharedVotingPower>
												<soleDispositivePower>0.00</soleDispositivePower>

				<sharedDispositivePower>4801370.00</sharedDispositivePower>
												<aggregateAmountOwned>4801370.00</aggregateAmountOwned>

				<isAggregateExcludeShares>N</isAggregateExcludeShares>

								<percentOfClass>5.0</percentOfClass>











			  			  <typeOfReportingPerson>IN</typeOfReportingPerson>




			</reportingPersonInfo>
			</reportingPersons>


	<items1To7>
		<item1>
			<securityTitle>Common Stock, $0.0001 par value per share</securityTitle>
			<issuerName>ALUMIS INC.</issuerName>

			<issuerPrincipalAddress>
			 <com:street1>280 East Grand Avenue</com:street1>
			  			  <com:city>South San Francisco</com:city>
			  <com:stateOrCountry>CA</com:stateOrCountry>
			  <com:zipCode>94080</com:zipCode>
			</issuerPrincipalAddress>

						<commentText>This Amendment No. 1 (this "Amendment No. 1" or this "Schedule 13D/A") amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on August 27, 2024 (the "Statement") by the Reporting Persons. Unless otherwise defined herein, capitalized terms used in this Amendment No. 1 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged.</commentText>
					</item1>


				<item3>
			<fundsSource>Item 3 of the Statement is hereby amended and supplemented as follows:

On May 2, 2025, Samsara LP purchased 159,920 shares of common stock in open market transactions at prices ranging from $3.97 to $4.84 per share (a weighted-average price of $4.55 per share).

On May 5, 2025, Samsara LP purchased (i) 138,368 shares of common stock in open market transactions at prices ranging from $4.19 to $5.1899 per share (a weighted-average price of $4.58 per share) and (ii) 22,002 shares of common stock in open market transactions at prices ranging from $5.19 to $5.48 per share (a weighted-average price of $5.27 per share).

All purchases of the securities described above were for cash and were funded by working capital of Samsara LP.

On May 21, 2025 (the "Closing Date"), pursuant to that certain Agreement and Plan of Merger, dated as of February 6, 2025 and April 21, 2025 (as amended, the "Merger Agreement"), by and among the Issuer, ACELYRIN, Inc. ("ACELYRIN"), and Arrow Merger Sub, Inc., a direct wholly owned subsidiary of the Issuer ("Merger Sub"), Merger Sub merged with and into ACELYRIN, with ACELYRIN continuing as the surviving corporation and as a wholly owned subsidiary of the Issuer (the "Merger").

Prior to the completion of the Merger, Samsara LP owned 2,523,022 shares of ACELYRIN common stock. As a result of the Merger and upon the Closing, among other things, each share of ACELYRIN common stock issued and outstanding as of immediately prior to the Closing was exchanged for the right to receive the number of shares of common stock of the Issuer equal to the exchange ratio of 0.4814. In the Closing, Samsara LP received 1,214,582 shares of common stock of the Issuer in exchange for its shares of ACELYRIN common stock.
</fundsSource>
		</item3>


				<item5>
			 <percentageOfClassSecurities>Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D set forth the aggregate number of shares of common stock and percentages of the shares of common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon an estimated 95,819,723 shares of common stock outstanding as of May 21, 2025, as reported by the Issuer to the Reporting Persons.

The Reporting Persons' ownership of the Issuer's securities consists of 4,801,370 shares of common stock directly held by Samsara LP. Samsara GP is the sole general partner of Samsara LP and Dr. Akkaraju is the managing member of Samsara GP. Each of Samsara GP and Dr. Akkaraju possesses power to direct the voting and disposition of the securities held by Samsara LP.</percentageOfClassSecurities>			<numberOfShares>Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D set forth the number of shares of common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference.</numberOfShares>			<transactionDesc>Except as set forth below, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer during the past sixty days.  </transactionDesc>			<listOfShareholders>No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the securities beneficially owned by any of the Reporting Persons.</listOfShareholders>			<date5PercentOwnership>Not applicable.</date5PercentOwnership>		</item5>


				<item7>
			<filedExhibits>Exhibit 99.1	Joint Filing Agreement

</filedExhibits>
		</item7>

	</items1To7>

<signatureInfo>

	<signaturePerson>
		<signatureReportingPerson>Samsara BioCapital, L.P. </signatureReportingPerson>

					<signatureDetails>
				<signature>/s/ Srinivas Akkaraju</signature>
				<title>By Samsara BioCapital GP, LLC, its General Partner, By Srinivas Akkaraju, Managing Member</title>
				<date>05/23/2025</date>
			</signatureDetails>

	</signaturePerson>

	<signaturePerson>
		<signatureReportingPerson>Samsara BioCapital GP, LLC </signatureReportingPerson>

					<signatureDetails>
				<signature>/s/ Srinivas Akkaraju</signature>
				<title>By Srinivas Akkaraju, Managing Member</title>
				<date>05/23/2025</date>
			</signatureDetails>

	</signaturePerson>

	<signaturePerson>
		<signatureReportingPerson>Srinivas Akkaraju</signatureReportingPerson>

					<signatureDetails>
				<signature>/s/ Srinivas Akkaraju</signature>
				<title>Srinivas Akkaraju</title>
				<date>05/23/2025</date>
			</signatureDetails>

	</signaturePerson>



</signatureInfo>
</formData>



</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ex-99-05242025_120519.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex-99-05242025_120519.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin-top:0px; margin-bottom:17.6px; padding-left:36px; font-size:11pt" align="center">EXHIBIT 99.1</p>
<p style="margin-top:0px; margin-bottom:17.6px; padding-left:36px; font-size:11pt" align="center">JOINT FILING AGREEMENT</p>
<p style="margin:0px; font-size:11pt">We, the undersigned, hereby express our agreement that the Schedule 13D (or any amendments thereto) relating to the common stock of <b style="font-size:10pt;font-weight:normal;">Alumis Inc.</b> is filed on behalf of each of us.</p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:17.6px; font-size:11pt">Dated: &nbsp;May 23, 2025</p>
<p style="margin:0px; font-size:11pt"><b>Samsara BioCapital, L.P.</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:30px; font-size:11pt; float:left">By: </p>
<p style="margin:0px; text-indent:-2px; font-size:11pt">Samsara BioCapital GP, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:30px; font-size:11pt; clear:left; float:left">its </p>
<p style="margin:0px; text-indent:-2px; font-size:11pt">General Partner</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:30px; font-size:11pt; float:left">By:</p>
<p style="margin:0px; text-indent:-2px; font-size:11pt"><u>/s/ Srinivas Akkaraju</u></p>
<p style="margin:0px; text-indent:30px; font-size:11pt; clear:left">Name: Srinivas Akkaraju</p>
<p style="margin:0px; text-indent:30px; font-size:11pt">Title: Managing Member</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px; font-size:11pt"><b>Samsara BioCapital GP, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:30px; font-size:11pt; float:left">By:</p>
<p style="margin:0px; text-indent:-2px; font-size:11pt"><u>/s/ Srinivas Akkaraju</u></p>
<p style="margin:0px; text-indent:30px; font-size:11pt; clear:left">Name: Srinivas Akkaraju</p>
<p style="margin:0px; text-indent:30px; font-size:11pt">Title: Managing Member</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px; font-size:11pt"><u>/s/ Srinivas Akkaraju </u></p>
<p style="margin:0px; font-size:11pt">Srinivas Akkaraju</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
