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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities |  |
Net loss | $ (294,233) | $ (154,993)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation | 19,457 | 8,625
Change in fair value of derivative liability | 5,406 | 119
Net accretion of discounts on marketable securities | (3,685) | (544)
Depreciation and amortization | 3,152 | 1,284
Non-cash lease expense | 60 | 2,010
Loss on disposal of fixed assets | 5 | 266
Write-off of deferred offering costs |  | 555
Loss on abandonment of right-of-use assets |  | 645
Changes in operating assets and liabilities: |  |
Research and development prepaid expenses | (10,763) | 5,526
Other prepaid expenses and other assets | (2,870) | (340)
Accounts payable | 8,506 | (642)
Research and development accrued expenses | 18,203 | 5,168
Other accrued expenses and current liabilities | 3,542 | 2,490
Operating lease liabilities | (1,858) | (144)
Net cash used in operating activities | (255,078) | (129,975)
Cash flows from investing activities |  |
Maturities of marketable securities | 128,000 | 76,250
Purchases of marketable securities | (240,058) | (11,279)
Purchases of property and equipment | (1,732) | (4,499)
Net cash (used in) provided by investing activities | (113,790) | 60,472
Cash flows from financing activities |  |
Proceeds from issuance of redeemable convertible preferred stock and derivative liability, net of offering costs | 258,461 | 89,778
Proceeds from initial public offering, net of underwriter discounts and commissions and other offering costs | 193,316 |
Proceeds from a private placement transaction | 40,000 |
Proceeds from issuance of common stock upon exercise of stock options | 596 | 453
Payments of deferred offering costs |  | (485)
Repurchase of unvested common stock shares issued upon early exercised stock options | (6) | (64)
Net cash provided by financing activities | 492,367 | 89,682
Net increase in cash, cash equivalents and restricted cash | 123,499 | 20,179
Cash, cash equivalents and restricted cash at beginning of period | 47,133 | 26,954
Cash, cash equivalents and restricted cash at end of period | 170,632 | 47,133
Supplemental disclosures: |  |
Conversion of 168,489,871 shares of redeemable convertible preferred stock upon the closing of initial public offering | 639,237 |
Settlement of derivative liability upon issuance of redeemable convertible preferred stock | (14,319) | (2,231)
Recognition of derivative liability upon issuance of redeemable convertible preferred stock | 8,913 | 2,112
Vesting of early exercised stock options and unvested restricted shares of common stock | 1,174 | 1,944
Right-of-use assets obtained in exchange for operating lease liabilities |  | 14,255
Property and equipment acquired through tenant improvement allowance |  | 16,691
Purchases of property and equipment in other accrued expenses and current liabilities |  | 49
Reconciliation of cash, cash equivalents and restricted cash: |  |
Cash and cash equivalents | 169,526 | 45,996
Restricted cash |  | 113
Restricted cash, non-current | 1,106 | 1,024
Total cash, cash equivalents and restricted cash | $ 170,632 | $ 47,133

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