<SEC-DOCUMENT>0001104659-26-003016.txt : 20260112
<SEC-HEADER>0001104659-26-003016.hdr.sgml : 20260112
<ACCEPTANCE-DATETIME>20260112215806
ACCESSION NUMBER:		0001104659-26-003016
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260108
FILED AS OF DATE:		20260112
DATE AS OF CHANGE:		20260112

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Tananbaum James B.
		CENTRAL INDEX KEY:			0001581754
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-42143
		FILM NUMBER:		26528306

	MAIL ADDRESS:	
		STREET 1:		3052 PACIFIC AVENUE
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94115

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALUMIS INC.
		CENTRAL INDEX KEY:			0001847367
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		280 EAST GRAND AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		650-231-6625

	MAIL ADDRESS:	
		STREET 1:		280 EAST GRAND AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ESKER THERAPEUTICS, INC.
		DATE OF NAME CHANGE:	20230427

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FL2021-001, Inc.
		DATE OF NAME CHANGE:	20210222
</SEC-HEADER>
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<SEQUENCE>1
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<DESCRIPTION>OWNERSHIP DOCUMENT
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    <schemaVersion>X0508</schemaVersion>

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    <periodOfReport>2026-01-08</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001847367</issuerCik>
        <issuerName>ALUMIS INC.</issuerName>
        <issuerTradingSymbol>ALMS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001581754</rptOwnerCik>
            <rptOwnerName>Tananbaum James B.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>900 LARKSPUR LANDING CIRCLE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 150</rptOwnerStreet2>
            <rptOwnerCity>LARKSPUR</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94939</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
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    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-01-08</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>117647</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>17.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5702536</value>
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            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
                <value>2026-01-08</value>
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            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>294117</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>17.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2908332</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
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        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
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                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F3"/>
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            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>194459</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1960337</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F5"/>
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        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
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                <sharesOwnedFollowingTransaction>
                    <value>1176470</value>
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            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
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        </nonDerivativeHolding>
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    <footnotes>
        <footnote id="F1">The shares are held of record by Foresite Capital Fund V, L.P. (&quot;Fund V&quot;). Foresite Capital Management V, LLC (&quot;FCM V&quot;) is the general partner of Fund V and may be deemed to have sole voting and dispositive power over such shares. James B. Tananbaum (&quot;Tananbaum&quot;), the managing member of FCM V, may be deemed to have sole voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Exchange Act, and disclaims beneficial ownership of the shares held by Fund V, except to the extent of such person's pecuniary interest in such securities.</footnote>
        <footnote id="F2">The shares are held of record by Foresite Capital Opportunity Fund V, L.P. (&quot;Opportunity Fund V&quot;). Foresite Capital Opportunity Management V, LLC (&quot;FCOM V&quot;) is the general partner of Opportunity Fund V and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCOM V, may be deemed to have sole voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), and, other than Opportunity Fund V, disclaims beneficial ownership of the shares held by Opportunity Fund V, except to the extent of such person's pecuniary interest in such securities.</footnote>
        <footnote id="F3">The shares are held of record by Foresite Capital Fund VI, L.P. (&quot;Fund VI&quot;). Foresite Capital Management VI, LLC (&quot;FCM VI&quot;) is the general partner of Fund VI and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCM VI, may be deemed to have sole voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Exchange Act, and disclaims beneficial ownership of the shares held by Fund VI, except to the extent of such person's pecuniary interest in such securities.</footnote>
        <footnote id="F4">The shares are held of record by Labs Co-Invest V, LLC (&quot;Labs Co-Invest&quot;).  FCM V is the managing member of Labs Co-Invest and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FCM V, may be deemed to have sole voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Exchange Act, and disclaims beneficial ownership of the shares held by Labs Co-Invest, except to the extent of such person's pecuniary interest in such securities.</footnote>
        <footnote id="F5">The shares are held of record by Foresite Labs Fund I, L.P. (&quot;Labs Fund I&quot;). Foresite Labs Management I, LLC (&quot;FLM I&quot;) is the general partner of Labs Fund I and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, the managing member of FLM I, may be deemed to have sole voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Exchange Act, and disclaims beneficial ownership of the shares held by Labs Fund I, except to the extent of such person's pecuniary interest in such securities.</footnote>
        <footnote id="F6">The shares are held of record by Foresite Labs Affiliates 2021, LLC (&quot;Labs Affiliates&quot;). Foresite Labs, LLC (&quot;Labs&quot;) is the managing member of Labs Affiliates and may be deemed to have sole voting and dispositive power over such shares. Tananbaum, a manager of Labs, may be deemed to share voting and dispositive power over such shares. Tananbaum disclaims the existence of a &quot;group&quot;, as defined in Rule 13d-5 of the Exchange Act, and disclaims beneficial ownership of the shares held by Labs Affiliates, except to the extent of such person's pecuniary interest in such securities.</footnote>
    </footnotes>

    <remarks>This Form 4 is one of three Form 4s filed on the date hereof in respect of these transactions. The Reporting Persons for the other Form 4s are Fund V, Opportunity Fund V, Labs Co-Invest, Fund VI, Labs Fund I, Labs Affiliates, FCM V, FCOM V, FCM VI, FLM I and Labs.</remarks>

    <ownerSignature>
        <signatureName>/s/ James B. Tananbaum</signatureName>
        <signatureDate>2026-01-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
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