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Condensed Consolidated Financial Statement Detail (Details) | 3 Months Ended | 9 Months Ended |  |  |  | 9 Months Ended |  |  | 3 Months Ended | 9 Months Ended |  |  | 9 Months Ended |  |  | 3 Months Ended | 9 Months Ended |  | 3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended
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Sep. 30, 2012 USD ($) | Sep. 30, 2011 USD ($) | Sep. 30, 2012 USD ($) | Sep. 30, 2011 USD ($) | Sep. 30, 2012 | Mar. 09, 2012 | Dec. 31, 2011 USD ($) | Sep. 30, 2012 Five year warrants issued in February 2010 [Member] USD ($) | Dec. 31, 2011 Five year warrants issued in February 2010 [Member] USD ($) | Feb. 01, 2010 Five year warrants issued in February 2010 [Member] USD ($) | Sep. 30, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Sep. 30, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Mar. 09, 2012 Five year warrants issued in March 2012 [Member] | Mar. 01, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Sep. 30, 2012 Warrants issued to private investors [Member] USD ($) | Dec. 31, 2011 Warrants issued to private investors [Member] USD ($) | Jun. 30, 2009 Warrants issued to private investors [Member] USD ($) | Sep. 30, 2012 Options Contract [Member] USD ($) | Sep. 30, 2012 Options Contract [Member] USD ($) | Sep. 30, 2012 Options Contract [Member] EUR (€) | Sep. 30, 2012 Option Contract 1 [Member] EUR (€) | Sep. 30, 2012 Option Contract 2 [Member] EUR (€) | Sep. 30, 2012 Common stock options and restricted stock units [Member] | Sep. 30, 2011 Common stock options and restricted stock units [Member] | Sep. 30, 2012 Common stock options and restricted stock units [Member] | Sep. 30, 2011 Common stock options and restricted stock units [Member] | Sep. 30, 2012 Convertible preferred stock [Member] | Sep. 30, 2011 Convertible preferred stock [Member] | Sep. 30, 2012 Convertible preferred stock [Member] | Sep. 30, 2011 Convertible preferred stock [Member] | Sep. 30, 2012 Warrants for common stock [Member] | Sep. 30, 2011 Warrants for common stock [Member] | Sep. 30, 2012 Warrants for common stock [Member] | Sep. 30, 2011 Warrants for common stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Antidilutive securities excluded from computation of earnings per share (in shares) | 22,356,000 | 5,644,000 | 18,730,000 | 5,535,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,730,000 | 4,036,000 | 5,788,000 | 3,837,000 | 0 | 0 | 0 | 90,000 | 16,626,000 | 1,608,000 | 12,942,000 | 1,608,000
Cash and cash equivalents [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Demand deposit | $ 11,400,000 |  | $ 11,400,000 |  |  |  | $ 21,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Money market funds | 30,800,000 |  | 30,800,000 |  |  |  | 27,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term Investments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term investments, U.S. treasury securities | 16,996,000 |  | 16,996,000 |  |  |  | 0 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notional amount of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative, amount of hedged item |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of foreign exchange option contracts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative, premiums |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 | 500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative, loss |  | 300,000 |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued liabilities [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued management incentive compensation | 2,821,000 |  | 2,821,000 |  |  |  | 4,096,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued payroll and other benefits | 2,510,000 |  | 2,510,000 |  |  |  | 3,007,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued clinical trial costs | 3,940,000 |  | 3,940,000 |  |  |  | 140,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued severance payments | 642,000 |  | 642,000 |  |  |  | 1,207,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other | 1,754,000 |  | 1,754,000 |  |  |  | 1,562,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 11,667,000 |  | 11,667,000 |  |  |  | 10,012,000 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  |  |  |  | 14,743,697 | 14,834,577 |  |  |  |  | 1,260,000 |  |  | 14,834,577 |  |  |  | 347,826 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) |  |  |  |  |  |  |  |  | $ 10.5 |  | $ 10.5 | $ 1.76 | $ 1.76 |  | $ 1.76 | $ 19.5 |  | $ 19.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrant liability | 32,100,000 |  | 32,100,000 |  |  |  |  |  |  | 300,000 |  | 32,100,000 | 32,100,000 |  | 6,400,000 |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on revaluation of warrant liability |  |  |  |  |  |  |  |  | $ (200,000) |  |  | $ 9,000,000 | $ 26,000,000 |  |  | $ (100,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
[1] | The condensed consolidated balance sheet as of December 31, 2011 has been derived from the audited financial statements as of that date included in the Company's Annual Report on Form 10-K for the year ended December 31, 2011.

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- Definition Investment in short-term money-market instruments (such as commercial paper, banker's acceptances, repurchase agreements, government securities, certificates of deposit, and so forth) which are highly liquid (that is, readily convertible to known amounts of cash) and so near their maturity that they present an insignificant risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify as cash equivalents by definition. Original maturity means an original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three-years ago does not become a cash equivalent when its remaining maturity is three months. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Cash Equivalents -URI http://asc.fasb.org/extlink&oid=6507016 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 8, 9 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable arising from transactions not otherwise specified in the taxonomy. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 43 -Section A -Paragraph 7 -Chapter 3 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6361293&loc=d3e6911-107765 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6361293&loc=d3e6935-107765 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Current Liabilities -URI http://asc.fasb.org/extlink&oid=6509677 Reference 7: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 9 -URI http://asc.fasb.org/extlink&oid=6361293&loc=d3e7018-107765 + Details
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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable for employer-related costs not otherwise specified in the taxonomy. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Investments which are intended to be sold in the short term (usually less than one year or the normal operating cycle, whichever is longer) including trading securities, available-for-sale securities, held-to-maturity securities, and other short-term investments not otherwise listed in the existing taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.2) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 1 -Subparagraph g -Article 7 + Details
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- Definition Portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents warrants not settleable in cash classified as equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=7578670&loc=d3e19207-110258 + Details
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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical trial costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References No definition available. + Details
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