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Concentration of Risk, Segment and Geographic Information (Details) (USD $) In Thousands, unless otherwise specified | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2011 | Sep. 30, 2011 | Jun. 30, 2011 | Mar. 31, 2011 | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of operating segments |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |
Revenues | $ 7,391 | $ 7,251 | $ 9,275 | $ 9,865 | $ 9,847 | [1] | $ 16,229 | [1] | $ 16,525 | [1] | $ 15,595 | [1] | $ 33,782 | $ 58,196 | $ 33,641
United States [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 14,134 | 20,447 | 25,306
Europe [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | 18,454 | 35,718 | 4,728
Asia Pacific [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,194 | $ 2,031 | $ 3,607
Customer Concentration Risk [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of major customers |  |  |  |  |  |  |  |  |  |  |  |  | 2 | 2 | 3
Revenues [Member] | Customer Concentration Risk [Member] | Customer 1 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, percentage (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  | 47.00% | 61.00% | 64.00%
Revenues [Member] | Customer Concentration Risk [Member] | Customer 2 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, percentage (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  | 33.00% | 32.00% | 13.00%
Revenues [Member] | Customer Concentration Risk [Member] | Customer 3 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, percentage (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11.00%
Accounts Receivable [Member] | Customer Concentration Risk [Member] | Customer 1 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, percentage (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  | 58.00% | 57.00% |
Accounts Receivable [Member] | Customer Concentration Risk [Member] | Customer 2 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration Risk [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Concentration risk, percentage (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  | 35.00% | 43.00% |
[1] | Revenue in the first three quarters of 2011 includes the recognition of $14.9 million of the non-recurring license fee received as consideration for the collaboration with Servier entered into in December 2010.

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- Definition For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 18 -URI http://asc.fasb.org/extlink&oid=6927468&loc=d3e6351-108592 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 21 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13537-108611 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 275 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=6927468&loc=d3e6404-108592 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 825 -SubTopic 10 -Section 50 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=7491637&loc=d3e13531-108611 + Details
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- Definition Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues. + References No definition available. + Details
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