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Compensation and Other Benefit Plans (Tables) | 12 Months Ended
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Dec. 31, 2012
Compensation and Other Benefit Plans [Abstract] |
Stock option activity | A summary of the status of the Company's stock option plans as of December 31, 2012, 2011 and 2010, and changes during the years ended on those dates is presented below:
|  | 2012 |  |  | 2011 |  |  | 2010 |
Options: |  | Shares |  |  | Price* |  |  | Shares |  |  | Price* |  |  | Shares |  |  | Price* |
Outstanding at beginning of year |  |  | 5,053,435 |  |  | $ | 12.55 |  |  |  | 2,331,450 |  |  | $ | 25.36 |  |  |  | 1,520,102 |  |  | $ | 38.40 |
Granted |  |  | 2,351,445 |  |  |  | 2.59 |  |  |  | 2,920,166 |  |  |  | 2.81 |  |  |  | 978,264 |  |  |  | 7.07 |
Exercised |  |  | (90,252 | ) |  |  | 1.68 |  |  |  | - |  |  |  | - |  |  |  | (19 | ) |  |  | 8.40 |
Forfeited, expired or cancelled |  |  | (526,245 | ) |  |  | 15.84 |  |  |  | (198,181 | ) |  |  | 35.56 |  |  |  | (166,897 | ) |  |  | 37.26 |
Outstanding at end of year |  |  | 6,788,383 |  |  |  | 8.99 |  |  |  | 5,053,435 |  |  |  | 12.55 |  |  |  | 2,331,450 |  |  |  | 25.36 |
Exercisable at end of year |  |  | 4,276,834 |  |  | $ | 12.42 |  |  |  | 3,366,807 |  |  | $ | 16.33 |  |  |  | 1,259,272 |  |  | $ | 36.51 |
* | Weighted-average exercise price
Unvested RSU activity | Unvested RSU activity for the year ended December 31, 2012 is summarized below:
|  |  |  |  | Weighted- |
|  | Number of |  |  | Average Grant- |
|  | Shares |  |  | Date Fair Value |
Unvested balance at December 31, 2011 |  |  | 903,874 |  |  | $ | 1.69 |
Granted |  |  | 1,292,923 |  |  |  | 2.83 |
Vested |  |  | (590,862 | ) |  |  | 2.27 |
Forfeited |  |  | (212,055 | ) |  |  | 1.69 |
Unvested balance at December 31, 2012 |  |  | 1,393,880 |  |  | $ | 2.75 |
Weighted average assumptions | The fair value of stock option awards was estimated using the Black-Scholes model with the following weighted average assumptions for the years ended December 31, 2012, 2011 and 2010:
|  | Year Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected volatility |  |  | 92 | % |  |  | 88 | % |  |  | 79 | %
Risk-free interest rate |  |  | 0.82 | % |  |  | 1.48 | % |  |  | 1.67 | %
Expected term |  | 5.6 years |  |  | 5.4 years |  |  | 5.3 years |
Stock-based compensation expense | The following table shows total stock-based compensation expense included in the consolidated statements of comprehensive loss for the years ended December 31, 2012, 2011 and 2010 (in thousands):
|  | Year Ended December 31, |
|  | 2012 |  |  | 2011 |  |  | 2010 |
Research and development |  | $ | 2,391 |  |  | $ | 3,672 |  |  | $ | 2,302 |
Selling, general and administrative |  |  | 1,893 |  |  |  | 4,087 |  |  |  | 2,611 |
Total stock-based compensation expense |  | $ | 4,284 |  |  | $ | 7,759 |  |  | $ | 4,913 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph g(1) -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph 64 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=6793087&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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