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Long-Term Debt and Other Arrangements (Details) | 12 Months Ended | 6 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |  | 12 Months Ended
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Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Dec. 31, 2012 Novartis Note [Member] USD ($) | Dec. 31, 2011 Novartis Note [Member] USD ($) | Dec. 31, 2010 Novartis Note [Member] USD ($) | Jul. 15, 2013 Servier Loan [Member] | Jan. 15, 2013 Servier Loan [Member] | Jul. 15, 2012 Servier Loan [Member] | Jan. 15, 2012 Servier Loan [Member] | Dec. 31, 2012 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] USD ($) | Dec. 31, 2010 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] EUR (€) | Sep. 30, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2011 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2010 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 27, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2012 Other Financings [Member] USD ($) | Dec. 31, 2011 Other Financings [Member] USD ($) | Dec. 31, 2010 Other Financings [Member] USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date |  |  |  | Jun. 30, 2015 |  |  |  |  |  |  |  |  |  |  |  | Jun. 15, 2015 |  |  |  |  |  |
Research and development expenses funded through loan facility, maximum (in hundredths) |  |  |  | 75.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum borrowing capacity under loan agreement |  |  |  | $ 50,000,000 |  |  |  |  |  |  |  |  |  | € 15,000,000 |  |  |  |  |  |  |  |
Variable rate basis |  |  |  | six-month LIBOR |  |  |  |  |  |  | Euro Inter-Bank Offered Rate ("EURIBOR") |  |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (in hundredths) |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate at period end (in hundredths) |  |  |  | 2.51% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Outstanding principal balance |  |  |  | 14,400,000 | 14,000,000 |  |  |  |  |  | 19,800,000 |  |  |  |  | 12,500,000 | 10,000,000 |  | 3,100,000 |  |  |
Periodic Payment, Principal |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 347,222 |  |  |  |  |  |  |
Accrued interest | (1,186,000) | (1,023,000) | (353,000) | 400,000 | 300,000 | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from loan |  |  |  |  |  |  |  |  |  |  |  | 19,500,000 |  |  | 4,600,000 |  |  |  |  |  |  |
Increase (Decrease) in term loan obligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,500,000 |  |  |  |  |  |  |
Initial interest rate during period (in hundredths) |  |  |  |  |  |  |  |  |  |  | 3.22% |  |  |  |  |  |  |  |  |  |  |
Interest rate during period (in hundredths) |  |  |  |  |  |  | 2.33% | 2.80% | 3.54% | 3.83% |  |  |  |  |  |  |  |  |  |  |  |
Unrealized foreign exchange gain (loss) | (295,000) | (513,000) | 0 |  |  |  |  |  |  |  | 400,000 | 100,000 |  |  |  |  |  |  |  |  |  |
Unrealized foreign exchange gains related to re-measurement of loan discount |  |  |  |  |  |  |  |  |  |  | 100,000 | 600,000 |  |  |  |  |  |  |  |  |  |
Unamortized discount on debt |  |  |  |  |  |  |  |  |  |  | 8,900,000 |  |  |  |  |  |  |  |  |  |  |
Amortization period for loan discount |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  |  |  |  |  |  |  |  | 1,400,000 | 1,400,000 |  |  |  |  |  |  |  |  |  |
Carrying value of the loan |  |  |  |  |  |  |  |  |  |  | 14,200,000 |  |  |  |  |  |  |  |  |  |  |
Recognition of deferred revenue |  |  |  |  |  |  |  |  |  |  | 1,400,000 | 1,400,000 |  |  |  |  |  |  |  |  |  |
Debt issuance costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 | 1,300,000 |  |  |  |  |  |
Final payment fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  |  | 875,000 |  |  |
Fixed interest rate accrued (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11.71% |  |  | 10.90% |  |  |
Number of monthly installments |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 27 | 42 |  |  |  |  |  |
Prepayment premium year one (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |
Prepayment premium year two (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |
Prepayment premium year thereafter (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.00% |  |  |  |  |  |
Aggregate number of unregistered shares of common stock called by warrants (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 263,158 |  |  | 39,346 |  |  |
Warrants exercise price (in dollars per share) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.14 |  |  | $ 3.54 |  |  |
Immediate Term for warrants exercisable (in years) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  |  |
Fair value of warrant liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 |  |  | 100,000 |  |  |
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2012 | 3,472,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2013 | 4,167,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2014 | 20,167,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2015 | 19,823,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt including current portion | 47,629,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Less current portion | (3,472,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total long-term debt | 44,157,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense | $ 4,387,000 | $ 2,462,000 | $ 385,000 | $ 397,000 | $ 341,000 | $ 354,000 |  |  |  |  | $ 2,097,000 | $ 2,087,000 | $ 0 |  |  | $ 1,850,000 | $ 0 | $ 0 |  | $ 43,000 | $ 34,000 | $ 31,000

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- Definition Including current and noncurrent portions, aggregate carrying amount of long-term borrowings as of the balance sheet date before deducting unamortized discount or premiums (if any). May include notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt, which had initial maturities beyond one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name FASB Staff Position (FSP) -Number APB14-1 -Paragraph 31 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 + Details
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- Definition Carrying amount of long-term debt, net of unamortized discount or premium, including current and noncurrent amounts. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03.16) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 7 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20, 22 -Article 5 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03.16) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 + Details
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- Definition Amount of long-term debt, sinking fund requirements, and other securities redeemable at fixed or determinable prices and dates maturing in the next fiscal year following the latest fiscal year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6802200&loc=d3e1835-112601 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 47 -Paragraph 10 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition Amount of long-term debt, sinking fund requirements, and other securities redeemable at fixed or determinable prices and dates maturing in the third fiscal year following the latest fiscal year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6802200&loc=d3e1835-112601 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 47 -Paragraph 10 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition Amount of long-term debt, sinking fund requirements, and other securities redeemable at fixed or determinable prices and dates maturing in the second fiscal year following the latest fiscal year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6802200&loc=d3e1835-112601 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 47 -Paragraph 10 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References No definition available. + Details
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- Definition The amount of previously reported deferred or unearned revenue that was recognized as revenue during the period. For cash flows, this element primarily pertains to amortization of deferred credits on long-term arrangements. As a noncash item, it is deducted from net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 13.A.4(a).Q1) -URI http://asc.fasb.org/extlink&oid=6600647&loc=d3e214044-122780 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 13 -Section A -Subsection 1 + Details
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- Definition Portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents warrants not settleable in cash classified as equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=7578670&loc=d3e19207-110258 + Details
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- Definition Amortization period for discount on the liability component of debt. + References No definition available. + Details
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- Definition The maximum percentage of aggregate costs of clinical research and development expenses that are funded through a debt instrument under collaborative arrangements and are not incurred by the Company. + References No definition available. + Details
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- Definition The initial average effective interest rate during the reporting period. + References No definition available. + Details
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- Definition The maximum borrowing capacity for a debt instrument under the loan agreement. + References No definition available. + Details
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- Definition The amount of final payment fee due on maturity of the loan. + References No definition available. + Details
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- Definition The cash inflow increase (Decrease) in borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References No definition available. + Details
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- Definition Carrying amount of long-term debt including final fee, net of unamortized discount or premium, scheduled to be repaid within one year or the normal operating cycle, if longer. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References No definition available. + Details
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- Definition Amount of long-term debt, sinking fund requirements including final fee payments, and other securities redeemable at fixed or determinable prices and dates maturing in the fourth fiscal year following the latest fiscal year. + References No definition available. + Details
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- Definition The number of monthly installment payments to fully repay the term loan. + References No definition available. + Details
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, in the first year of the loan. + References No definition available. + Details
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, thereafter. + References No definition available. + Details
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- Definition The aggregate unrealized foreign currency transaction gain related to the re-measurement of the loan discount. + References No definition available. + Details
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