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Quarterly Financial Information (unaudited) (Details) (USD $) | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 31, 2012 | Sep. 30, 2012 | Jun. 30, 2012 | Mar. 31, 2012 | Dec. 31, 2011 | Sep. 30, 2011 | Jun. 30, 2011 | Mar. 31, 2011 | Sep. 30, 2011 | Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Quarterly Financial Information (unaudited) [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues | $ 7,391,000 |  | $ 7,251,000 |  | $ 9,275,000 |  | $ 9,865,000 |  | $ 9,847,000 | [1] | $ 16,229,000 | [1] | $ 16,525,000 | [1] | $ 15,595,000 | [1] |  | $ 33,782,000 | $ 58,196,000 | $ 33,641,000
Total operating costs and expenses | (19,834,000) |  | (23,404,000) |  | (22,765,000) |  | (24,227,000) |  | (21,894,000) |  | (23,147,000) |  | (24,394,000) |  | (22,716,000) |  |  | (90,230,000) | (92,151,000) | (100,745,000)
Other income (expense), net | 14,985,000 | [2] | (10,772,000) | [2] | (2,665,000) | [2] | (16,063,000) | [2] | 312,000 |  | 375,000 |  | (261,000) |  | 801,000 |  |  |  |  |
Income tax expense | 0 |  | 74,000 |  | 0 |  | 0 |  | 0 |  | 0 |  | 0 |  | (15,000) |  |  | 74,000 | (15,000) | (27,000)
Net income (loss) | 2,542,000 |  | (26,851,000) |  | (16,155,000) |  | (30,425,000) |  | (11,735,000) |  | (6,543,000) |  | (8,130,000) |  | (6,335,000) |  |  | (70,889,000) | (32,743,000) | (68,756,000)
Basic and diluted net loss (income) per share of common stock (in dollars per share) | $ 0.03 |  | $ (0.39) |  | $ (0.24) |  | $ (0.69) |  | $ (0.34) |  | $ (0.2) |  | $ (0.27) |  | $ (0.22) |  |  | $ (1.1) | $ (1.04) | $ (3.69)
Licensing fee, non-recurring |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 14,900,000 |  |  |
[1] | Revenue in the first three quarters of 2011 includes the recognition of $14.9 million of the non-recurring license fee received as consideration for the collaboration with Servier entered into in December 2010.
[2] | Fluctuations in 2012 primarily relate to (losses) gains on the revaluation of the contingent warrant liabilities.

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