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Commitments and Contingencies (Details) (USD $) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Apr. 08, 2011
Commitments and Contingencies [Abstract] |  |  |  |  |
Royalties paid, minimum (in hundredths) | 1.50% |  |  |  |
Royalties paid, maximum (in hundredths) | 14.00% |  |  |  |
Sublicense fees paid, maximum (in hundredths) | 40.00% |  |  |  |
Estimate of milestone payments | $ 96,000,000 |  |  |  |
Estimated future minimum lease commitments [Abstract] |  |  |  |  |
2013 | 2,662,000 | [1] |  |  |
2014 | 795,000 | [1] |  |  |
Minimum lease payments | 3,457,000 | [1] |  |  |
Total rental expense | 4,500,000 |  | 5,100,000 | 5,100,000 |
Sublease income | 100,000 |  |  |  |
Future sublease income | 900,000 |  |  |  |
Sublease income receivable | $ 200,000 |  |  |  |
Number of buildings lease agreements of which renewed | 3 |  |  |  |
Renewed period of operating lease agreement | 10 years |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Number of complaints filed |  |  |  |  | 4
Number of cases dismissed | 4 |  |  |  |
Number of cases transferred to a different court | 4 |  |  |  |
[1] | Operating leases are net of future sublease income of $0.9 million.

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