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Consolidated Financial Statement Detail (Details) | 12 Months Ended |  |  |  |  |  |  |  |  | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Dec. 31, 2012 Equipment and Furniture [Member] USD ($) | Dec. 31, 2011 Equipment and Furniture [Member] USD ($) | Dec. 31, 2012 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2011 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2012 Construction-in-Progress [Member] USD ($) | Dec. 31, 2011 Construction-in-Progress [Member] USD ($) | Dec. 31, 2012 Land [Member] USD ($) | Dec. 31, 2011 Land [Member] USD ($) | Dec. 31, 2012 Options Contract [Member] USD ($) | Dec. 31, 2011 Options Contract [Member] USD ($) | Dec. 31, 2012 Options Contract [Member] EUR (€) | Dec. 31, 2012 Option Contract 1 [Member] EUR (€) | Dec. 31, 2012 Option Contract 2 [Member] EUR (€) | Dec. 31, 2012 Demand Deposits [Member] USD ($) | Dec. 31, 2011 Demand Deposits [Member] USD ($) | Dec. 31, 2012 Money Market Funds [Member] USD ($) | Dec. 31, 2011 Money Market Funds [Member] USD ($)
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,800,000 | $ 21,100,000 | $ 37,500,000 | $ 27,200,000
Short-term Investments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term investments | 39,987,000 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notional amount of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |  |
Number of foreign exchange option contracts |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |
Derivative, amount of hedged item |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 | 15,000,000 |  |  |  |
Derivative, premiums |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  |  |  |  |  |
Derivative fair value |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  |  |  |  |  |  |  |
Derivative, loss |  |  |  |  |  |  |  |  |  |  |  | 700,000 | 300,000 |  |  |  |  |  |  |
Receivables [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade receivables, net | 7,477,000 | 11,820,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other receivables | 772,000 | 512,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 8,249,000 | 12,332,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, gross | 49,532,000 | 56,256,000 |  | 25,734,000 | 33,483,000 | 21,656,000 | 21,490,000 | 1,832,000 | 973,000 | 310,000 | 310,000 |  |  |  |  |  |  |  |  |
Less: Accumulated depreciation and amortization | (41,389,000) | (43,547,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, net | 8,143,000 | 12,709,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation and amortization expense | 4,124,000 | 5,357,000 | 5,721,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued Liabilities [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued clinical trial costs | 4,702,000 | 140,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued management incentive compensation | 3,802,000 | 4,096,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued payroll and other benefits | 2,461,000 | 3,007,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued severance payments | 490,000 | 1,207,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other | 1,535,000 | 1,562,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 12,990,000 | 10,012,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Revenue [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue deferred | 5,900,000 | 12,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized | $ 9,400,000 | $ 17,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition Gross amount of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Principles Board Opinion (APB) -Number 12 -Paragraph 5 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.13) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Amount, net of accumulated depreciation, depletion and amortization, of long-lived physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 8 -Article 7 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 12 -Paragraph 5 -Subparagraph b, c -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.13) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 13 -Subparagraph a -Article 5 + Details
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- Definition The total amount due to the entity within one year of the balance sheet date (or one operating cycle, if longer) from outside sources, including trade accounts receivable, notes and loans receivable, as well as any other types of receivables, net of allowances established for the purpose of reducing such receivables to an amount that approximates their net realizable value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 3 -Subparagraph a -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.3,4) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 4 -Article 5 + Details
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- Definition Investments which are intended to be sold in the short term (usually less than one year or the normal operating cycle, whichever is longer) including trading securities, available-for-sale securities, held-to-maturity securities, and other short-term investments not otherwise listed in the existing taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.2) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 1 -Subparagraph g -Article 7 + Details
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- Definition Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical trial costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References No definition available. + Details
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