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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Revenues: |  |  |
License and collaborative fees | $ 5,727 | $ 17,991 | $ 2,182
Contract and other | 26,852 | 40,037 | 27,174
Net product sales | 1,044 | 0 | 0
Royalties | 159 | 168 | 4,285
Total revenues | 33,782 | 58,196 | 33,641
Operating expenses: |  |  |
Research and development | 68,231 | 68,137 | 77,413
Selling, general and administrative | 16,782 | 24,014 | 23,250
Restructuring | 5,074 | 0 | 82
Cost of sales | 143 | 0 | 0
Total operating expenses | 90,230 | 92,151 | 100,745
Loss from operations | (56,448) | (33,955) | (67,104)
Other income (expense): |  |  |
Interest expense | (4,387) | (2,462) | (385)
Other expense | (956) | (177) | (3,523)
Revaluation of contingent warrant liabilities | (9,172) | 3,866 | 2,283
Net loss before taxes | (70,963) | (32,728) | (68,729)
Provision for income tax benefit (expense) | 74 | (15) | (27)
Net loss | (70,889) | (32,743) | (68,756)
Basic and diluted net loss per share of common stock (in dollars per share) | $ (1.1) | $ (1.04) | $ (3.69)
Shares used in computing basic and diluted net loss per share of common stock (in shares) | 64,629 | 31,590 | 18,613
Comprehensive loss: |  |  |
Net unrealized gains on available-for-sale securities | 8 | 0 | 0
Comprehensive loss | $ (70,881) | $ (32,743) | $ (68,756)

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- Definition The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Research Bulletin (ARB) -Number 43 -Paragraph 5A -Chapter 4 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 4 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.4) -URI http://asc.fasb.org/extlink&oid=6880815&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 330 -SubTopic 10 -Section 30 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6386349&loc=d3e3636-108311 + Details
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- Definition Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS). + References No definition available. + Details
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- Definition The increases (decreases) in the market value of warrants whose gains (losses) were included in earnings. + References No definition available. + Details
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