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Condensed Consolidated Financial Statement Detail (Details) | 3 Months Ended | 9 Months Ended |  | 1 Months Ended |  | 1 Months Ended | 9 Months Ended |  |  |  | 1 Months Ended |  | 3 Months Ended | 9 Months Ended |  |  |  |  | 3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended
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Sep. 30, 2013 USD ($) | Sep. 30, 2012 | Sep. 30, 2013 USD ($) | Sep. 30, 2012 | Dec. 31, 2012 USD ($) | Feb. 28, 2010 Five year warrants issued in February 2010 [Member] USD ($) | Feb. 28, 2010 Five year warrants issued in February 2010 [Member] | Mar. 31, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Sep. 30, 2013 Five year warrants issued in March 2012 [Member] USD ($) | Sep. 30, 2013 Five year warrants issued in March 2012 [Member] | Dec. 31, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Mar. 31, 2012 Five year warrants issued in March 2012 [Member] | Jun. 30, 2009 Warrants issued to private investors [Member] USD ($) | Jun. 30, 2009 Warrants issued to private investors [Member] | Sep. 30, 2012 Options Contract [Member] USD ($) | Sep. 30, 2013 Options Contract [Member] USD ($) Contract | Sep. 30, 2012 Options Contract [Member] USD ($) | Sep. 30, 2013 Options Contract [Member] EUR (€) | Sep. 30, 2013 Option Contract 1 [Member] EUR (€) | Sep. 30, 2013 Option Contract 2 [Member] EUR (€) | Sep. 30, 2013 Demand Deposits [Member] USD ($) | Dec. 31, 2012 Demand Deposits [Member] USD ($) | Sep. 30, 2013 Money Market Funds [Member] USD ($) | Dec. 31, 2012 Money Market Funds [Member] USD ($) | Sep. 30, 2013 Common stock options and restricted stock units [Member] | Sep. 30, 2012 Common stock options and restricted stock units [Member] | Sep. 30, 2013 Common stock options and restricted stock units [Member] | Sep. 30, 2012 Common stock options and restricted stock units [Member] | Sep. 30, 2013 Warrants for common stock [Member] | Sep. 30, 2012 Warrants for common stock [Member] | Sep. 30, 2013 Warrants for common stock [Member] | Sep. 30, 2012 Warrants for common stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Antidilutive securities excluded from computation of earnings per share (in shares) | 22,795,000 | 22,356,000 | 22,123,000 | 18,730,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,825,000 | 5,730,000 | 6,017,000 | 5,788,000 | 15,970,000 | 16,626,000 | 16,106,000 | 12,942,000
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 16,200,000 | $ 7,800,000 | $ 57,800,000 | $ 37,500,000 |  |  |  |  |  |  |  |
Short-term Investments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term investments, U.S. treasury securities | 0 |  | 0 |  | 39,987,000 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notional amount of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of foreign exchange option contracts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative, amount of hedged item |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Derivative, premiums |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative, loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 200,000 | 700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued liabilities [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued payroll and other benefits | 3,112,000 |  | 3,112,000 |  | 3,978,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued management incentive compensation | 2,708,000 |  | 2,708,000 |  | 2,461,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued clinical trial costs | 500,000 |  | 500,000 |  | 4,702,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other | 1,696,000 |  | 1,696,000 |  | 1,904,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 8,016,000 |  | 8,016,000 |  | 13,045,000 | [1] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  |  |  |  |  |  |  | 1,260,000 |  |  | 13,673,183 |  | 14,834,577 |  | 347,826 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price (in dollars per share) |  |  |  |  |  |  | $ 10.50 |  | $ 1.76 |  |  |  |  | $ 19.50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrant liability | 52,000 |  | 52,000 |  |  |  |  |  |  | 39,100,000 |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on revaluation of warrant liability |  |  |  |  |  |  |  |  |  | 25,700,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant Term |  |  |  |  |  |  | 5 years |  | 5 years |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reclassification of warrant liability to equity |  |  | $ 1,600,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
[1] | The condensed consolidated balance sheet as of December 31, 2012 has been derived from the audited consolidated financial statements as of that date included in the Company's Annual Report on Form 10-K for the year ended December 31, 2012.

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Balance Type: | na
Period Type: | duration