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Consolidated Financial Statement Detail (Details) | 12 Months Ended | 1 Months Ended |  | 1 Months Ended | 12 Months Ended |  |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |  |  |  | 12 Months Ended |  |  |  |
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Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Feb. 28, 2010 Five year warrants issued in February 2010 [Member] USD ($) | Feb. 28, 2010 Five year warrants issued in February 2010 [Member] | Mar. 31, 2012 Five year warrants issued in March 2012 [Member] USD ($) | Dec. 31, 2013 Five year warrants issued in March 2012 [Member] USD ($) | Dec. 31, 2013 Five year warrants issued in March 2012 [Member] | Mar. 31, 2012 Five year warrants issued in March 2012 [Member] | Jun. 30, 2009 Warrants issued to private investors [Member] USD ($) | Dec. 31, 2013 Warrants issued to private investors [Member] USD ($) | Dec. 31, 2012 Warrants issued to private investors [Member] USD ($) | Jun. 30, 2009 Warrants issued to private investors [Member] | Dec. 31, 2013 Equipment and Furniture [Member] USD ($) | Dec. 31, 2012 Equipment and Furniture [Member] USD ($) | Dec. 31, 2013 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2012 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2013 Construction-in-Progress [Member] USD ($) | Dec. 31, 2012 Construction-in-Progress [Member] USD ($) | Dec. 31, 2013 Land [Member] USD ($) | Dec. 31, 2012 Land [Member] USD ($) | Dec. 31, 2013 Options Contract [Member] USD ($) Contract | Dec. 31, 2012 Options Contract [Member] USD ($) | Dec. 31, 2011 Options Contract [Member] USD ($) | Dec. 31, 2013 Options Contract [Member] EUR (€) | Dec. 31, 2013 Option Contract 1 [Member] EUR (€) | Dec. 31, 2013 Option Contract 2 [Member] EUR (€) | Dec. 31, 2013 Demand Deposits [Member] USD ($) | Dec. 31, 2012 Demand Deposits [Member] USD ($) | Dec. 31, 2013 Money Market Funds [Member] USD ($) | Dec. 31, 2012 Money Market Funds [Member] USD ($)
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 18,900,000 | $ 7,800,000 | $ 82,800,000 | $ 37,500,000
Short-term Investments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term investments | 19,990,000 | 39,987,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notional amount of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |  |
Number of foreign exchange option contracts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |  |  |  |
Derivative, amount of hedged item |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 | 15,000,000 |  |  |  |
Derivative, premiums |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  |  |  |  |  |  |
Derivative fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 | 500,000 |  |  |  |  |  |  |  |
Derivative, loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 | 700,000 | 300,000 |  |  |  |  |  |  |
Receivables [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade receivables, net | 3,731,000 | 7,477,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other receivables | 50,000 | 772,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 3,781,000 | 8,249,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, gross | 38,216,000 | 49,532,000 |  |  |  |  |  |  |  |  |  |  |  | 28,365,000 | 25,734,000 | 9,316,000 | 21,656,000 | 225,000 | 1,832,000 | 310,000 | 310,000 |  |  |  |  |  |  |  |  |  |
Less: Accumulated depreciation and amortization | (31,760,000) | (41,389,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, net | 6,456,000 | 8,143,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation and amortization expense | 2,575,000 | 4,124,000 | 5,357,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued Liabilities [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued management incentive compensation | 4,386,000 | 3,978,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued payroll and other benefits | 3,009,000 | 2,461,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued clinical trial costs | 878,000 | 4,702,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other | 1,661,000 | 1,904,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 9,934,000 | 13,045,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Revenue [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue deferred | 1,500,000 | 5,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized | 4,900,000 | 9,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  |  |  |  | 1,260,000 |  |  | 12,562,682 | 14,834,577 |  |  |  | 347,826 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) |  |  |  | $ 10.50 |  | $ 1.76 |  |  |  | $ 19.50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrant liability |  | 15,000,000 |  |  |  |  | 68,700,000 |  |  |  | 1,200,000 | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on revaluation of warrant liability |  |  |  |  |  |  | 59,900,000 |  |  |  | (1,100,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant Term |  |  |  | 5 years |  | 5 years |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reclassification of warrant liability to equity | $ 6,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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