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Long-Term Debt and Other Arrangements (Details) | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 12 Months Ended
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Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Dec. 31, 2011 USD ($) | Dec. 31, 2013 Novartis Note [Member] USD ($) | Dec. 31, 2012 Novartis Note [Member] USD ($) | Dec. 31, 2011 Novartis Note [Member] USD ($) | Jan. 31, 2014 Novartis Note [Member] Subsequent Event [Member] USD ($) | Jan. 31, 2014 Servier Loan [Member] USD ($) | Dec. 31, 2013 Servier Loan [Member] USD ($) | Dec. 31, 2012 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] EUR (€) | Dec. 31, 2013 Servier Loan [Member] Minimum [Member] | Dec. 31, 2013 Servier Loan [Member] Maximum [Member] | Sep. 30, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) Installment | Dec. 31, 2013 General Electric Capital Corporation Term Loan [Member] USD ($) Installment | Dec. 31, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2011 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 27, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2013 Other Financings [Member] USD ($) | Dec. 31, 2012 Other Financings [Member] USD ($) | Dec. 31, 2011 Other Financings [Member] USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date |  |  |  | Jun. 30, 2015 |  |  |  |  |  |  |  |  |  |  |  | Jun. 15, 2015 |  |  |  |  |  |
Research and development expenses funded through loan facility, maximum (in hundredths) |  |  |  | 75.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum borrowing capacity under loan agreement |  |  |  | $ 50,000,000 |  |  |  |  |  |  |  | € 15,000,000 |  |  |  |  |  |  |  |  |  |
Variable rate basis |  |  |  | six-month LIBOR |  |  |  |  | Euro Inter-Bank Offered Rate ("EURIBOR") |  |  |  |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (in hundredths) |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate at period end (in hundredths) |  |  |  | 2.35% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Outstanding principal balance |  |  |  | 14,800,000 | 14,400,000 |  |  |  | 20,600,000 |  |  |  |  |  |  | 9,400,000 | 12,500,000 | 10,000,000 | 3,100,000 |  |  |
Periodic Payment, Principal |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 347,222 |  |  |  |  |  |  |
Accrued interest | (2,284,000) | (1,186,000) | (1,023,000) | 400,000 | 400,000 | 300,000 |  | 1,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from loan |  |  |  |  |  |  |  |  |  |  | 19,500,000 |  |  |  | 4,600,000 |  |  |  |  |  |  |
Percentage of milestone received (in hundredths) |  |  |  |  |  |  | 0.25% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone received under the collaboration agreement |  |  |  |  |  |  | 7,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repayment of debt |  |  |  |  |  |  | 1,750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in term loan obligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,500,000 |  |  |  |  |  |  |
Initial interest rate during period (in hundredths) |  |  |  |  |  |  |  |  | 3.22% |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate reset semi-annually during period (in hundredths) |  |  |  |  |  |  |  |  | 2.39% |  |  |  | 2.33% | 3.83% |  |  |  |  |  |  |  |
Unrealized foreign exchange gain (loss) | (662,000) | (295,000) | (513,000) |  |  |  |  |  | 800,000 | 400,000 | 100,000 |  |  |  |  |  |  |  |  |  |  |
Unrealized foreign exchange gains related to re-measurement of loan discount |  |  |  |  |  |  |  |  | 200,000 | 100,000 | 600,000 |  |  |  |  |  |  |  |  |  |  |
Euro to US Dollar exchange rates | 1.3766 | 1.3766 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unamortized discount on debt |  |  |  |  |  |  |  |  | 8,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization period for loan discount |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  |  |  |  |  |  | 1,600,000 | 1,400,000 | 1,400,000 |  |  |  |  |  |  |  |  |  |  |
Carrying value of the loan |  |  |  |  |  |  |  |  | 16,500,000 | 14,200,000 |  |  |  |  |  |  |  |  |  |  |  |
Recognition of deferred revenue |  |  |  |  |  |  |  |  | 1,600,000 | 1,400,000 | 1,400,000 |  |  |  |  |  |  |  |  |  |  |
Debt issuance costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 | 1,300,000 |  |  |  |  |  |
Final payment fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  |  | 875,000 |  |  |
Fixed interest rate accrued (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11.71% |  |  | 10.90% |  |  |
Number of monthly installments |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 27 | 42 |  |  |  |  |  |
Prepayment premium year one (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |
Prepayment premium year two (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |
Prepayment premium year thereafter (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.00% |  |  |  |  |  |
Aggregate number of unregistered shares of common stock called by warrants (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 263,158 |  |  | 39,346 |  |  |
Warrants exercise price (in dollars per share) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.14 |  |  | $ 3.54 |  |  |
Immediate Term for warrants exercisable (in years) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years | 5 years |  |  |  |  |  |
Fair value of warrant liability |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 |  |  | 100,000 |  |  |
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2014 | 5,917,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2015 | 19,127,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2016 | 20,649,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Long-term debt including current portion | 45,693,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Less current portion | (5,917,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total long-term debt | 39,776,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense | $ 4,631,000 | $ 4,387,000 | $ 2,462,000 | $ 362,000 | $ 397,000 | $ 341,000 |  |  | $ 2,152,000 | $ 2,097,000 | $ 2,087,000 |  |  |  |  | $ 2,064,000 | $ 1,850,000 | $ 0 |  | $ 53,000 | $ 43,000 | $ 34,000

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- Definition The amount of previously reported deferred or unearned revenue that was recognized as revenue during the period. For cash flows, this element primarily pertains to amortization of deferred credits on long-term arrangements. As a noncash item, it is deducted from net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 13.A.4(a).Q1) -URI http://asc.fasb.org/extlink&oid=27012821&loc=d3e214044-122780 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 13 -Section A -Subsection 1 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
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- Definition Fair value portion of warrants not settleable in cash classified as equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=25499696&loc=d3e19207-110258 + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition Amortization period for discount on the liability component of debt. + References No definition available. + Details
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Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

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- Definition The maximum percentage of aggregate costs of clinical research and development expenses that are funded through a debt instrument under collaborative arrangements and are not incurred by the Company. + References No definition available. + Details
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Balance Type: | na
Period Type: | duration

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- Definition The initial average effective interest rate during the reporting period. + References No definition available. + Details
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Namespace Prefix: | xoma_
Data Type: | num:percentItemType
Balance Type: | na
Period Type: | duration

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- Definition The initial average effective interest rate reset semi annually during the reporting period. + References No definition available. + Details
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Data Type: | num:percentItemType
Balance Type: | na
Period Type: | duration

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- Definition The maximum borrowing capacity for a debt instrument under the loan agreement. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition The amount of final payment fee due on maturity of the loan. + References No definition available. + Details
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Namespace Prefix: | xoma_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition Refers to Immediate Term for warrants exercisable before these shares mature. + References No definition available. + Details
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Data Type: | xbrli:durationItemType
Balance Type: | na
Period Type: | duration

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- Definition The cash inflow increase (Decrease) in borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | debit
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- Definition Carrying amount of long-term debt including final fee, net of unamortized discount or premium, scheduled to be repaid within one year or the normal operating cycle, if longer. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
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- Definition Carrying amount of long-term debt including final fee payment amount, net of unamortized discount or premium, excluding amounts to be repaid within one year or the normal operating cycle, if longer (current maturities). Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

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- Definition Refers to the timing of required repayments to its customers. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
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- Definition Amount of long-term debt, sinking fund requirements including final fee payments, and other securities redeemable at fixed or determinable prices and dates maturing in the fourth fiscal year following the latest fiscal year. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
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- Definition Carrying amount of long-term debt and final fee payments, net of unamortized discount or premium, including current and noncurrent amounts. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
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- Definition Refers to the payment percentage of milestone received under the collaboration agreement. + References No definition available. + Details
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Namespace Prefix: | xoma_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- Definition The number of monthly installment payments to fully repay the term loan. + References No definition available. + Details
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Data Type: | xbrli:integerItemType
Balance Type: | na
Period Type: | duration

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- Definition Refers to percentage of milestone received. + References No definition available. + Details
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Data Type: | num:percentItemType
Balance Type: | na
Period Type: | duration

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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, in the first year of the loan. + References No definition available. + Details
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Data Type: | num:percentItemType
Balance Type: | na
Period Type: | instant

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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, thereafter. + References No definition available. + Details
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Data Type: | num:percentItemType
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, in the second year of the loan. + References No definition available. + Details
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- Definition The aggregate unrealized foreign currency transaction gain related to the re-measurement of the loan discount. + References No definition available. + Details
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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
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