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CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Cash flows from operating activities: |  |  |
Net loss | $ (124,058) | $ (71,065) | $ (32,743)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 2,575 | 4,124 | 5,357
Common stock contribution to 401(k) | 828 | 1,134 | 1,046
Stock-based compensation expense | 5,099 | 4,284 | 7,759
Accrued interest on interest bearing obligations | 2,284 | 1,186 | 1,023
Revaluation of contingent warrant liabilities | 61,039 | 9,172 | (3,866)
Restructuring charge related to long-lived assets | 0 | 2,460 | 0
Amortization of debt discount, final payment fee on debt, and debt issuance costs | 2,470 | 1,958 | 1,360
Loss on sale costs and retirement of property & equipment | 281 | 29 | 107
Unrealized loss on foreign currency exchange | 662 | 295 | 513
Unrealized loss on foreign exchange options | 127 | 714 | 298
Other non-cash adjustments | (20) | (11) | 0
Changes in assets and liabilities: |  |  |
Trade and other receivables, net | 4,486 | 4,064 | 8,532
Prepaid expenses and other assets | 481 | (158) | (2,469)
Accounts payable and accrued liabilities | 2,901 | 4,485 | (2,144)
Deferred revenue | (3,399) | (3,511) | (13,794)
Other liabilities | (1,671) | 75 | (41)
Net cash used in operating activities | (45,915) | (40,765) | (29,062)
Cash flows from investing activities: |  |  |
Purchases of investments | (19,991) | (56,970) | 0
Proceeds from maturities of investments | 40,000 | 17,000 | 0
Net purchase of property and equipment | (1,169) | (2,509) | (3,304)
Proceeds from sale of property and equipment | 0 | 463 | 0
Net provided by (used in) investing activities | 18,840 | (42,016) | (3,304)
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 84,338 | 76,498 | 15,143
Proceeds from the exercise of warrants | 2,176 | 993 | 0
Proceeds from issuance of long-term debt, net of issuance costs | 0 | 4,434 | 28,836
Principal payments of debt | (3,125) | (2,143) | 0
Net cash provided financing activities | 83,389 | 79,782 | 43,979
Effect of exchange rate changes on cash | 0 | 0 | (573)
Net increase in cash and cash equivalents | 56,314 | (2,999) | 11,040
Cash and cash equivalents at the beginning of the period | 45,345 | 48,344 | 37,304
Cash and cash equivalents at the end of the period | 101,659 | 45,345 | 48,344
Cash paid during the year for: |  |  |
Interest | 1,262 | 1,035 | 0
Income taxes | 0 | 0 | 15
Non-cash investing and financing activities: |  |  |
Issuance of warrants | 0 | 6,390 | 0
Reclassification of contingent warrant liability to equity upon exercise of warrants | (6,171) | (940) | 0
Interest added to principal balances on long-term debt | 935 | 1,160 | 669
Investment in Symplmed Pharamaceuticals, LLC | 171 | 0 | 0
Discount on long-term debt | $ 0 | $ (55) | $ (215)

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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3255-108585 + Details
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- Definition The cash inflow from maturities, prepayments, calls and collections of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock warrants. + References No definition available. + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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- Definition The amount of debt discount that recognized at the issuance of the instrument that has yet to be amortized during the period. + References No definition available. + Details
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- Definition Noncash value of warrants and rights issued. "Equity warrants and rights outstanding" represents derivative securities that give the holder the right to purchase securities (usually equity) from the issuer at a specific price within a certain time frame. Warrants are often included in a new debt issue to entice investors by a higher return potential. + References No definition available. + Details
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