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Commitments and Contingencies (Details) (USD $) | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Commitments and Contingencies [Abstract] |  |  |  |
Royalties paid, minimum (in hundredths) | 1.00% |  |  |
Royalties paid, maximum (in hundredths) | 5.00% |  |  |
Sublicense fees paid, maximum (in hundredths) | 40.00% |  |  |
Estimate of milestone payments | $ 76,600,000 |  |  |
Estimated future minimum lease commitments [Abstract] |  |  |  |
2014 | 3,661,000 | [1] |  |
2015 | 3,640,000 | [1] |  |
2016 | 3,749,000 | [1] |  |
2017 | 3,862,000 | [1] |  |
2018 | 3,978,000 | [1] |  |
Thereafter | 15,723,000 | [1] |  |
Minimum lease payments | 34,613,000 | [1] |  |
Total rental expense | 3,500,000 |  | 4,500,000 | 5,100,000
Restructuring charges | 328,000 |  | 5,074,000 | 0
Sublease income | 100,000 |  |  |
Future sublease income | $ 100,000 |  |  |
[1] | Operating leases are net of future sublease income of $0.1 million.

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