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Long-Term Debt and Other Financings (Details) | 3 Months Ended | 9 Months Ended | 1 Months Ended | 3 Months Ended | 9 Months Ended |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  | 9 Months Ended | 1 Months Ended | 3 Months Ended | 9 Months Ended |  |  |  | 3 Months Ended | 9 Months Ended
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Sep. 30, 2014 USD ($) | Sep. 30, 2013 USD ($) | Sep. 30, 2014 USD ($) | Sep. 30, 2013 USD ($) | Jan. 31, 2014 Novartis Note [Member] USD ($) | Sep. 30, 2014 Novartis Note [Member] USD ($) | Sep. 30, 2013 Novartis Note [Member] USD ($) | Sep. 30, 2014 Novartis Note [Member] USD ($) | Sep. 30, 2013 Novartis Note [Member] USD ($) | Dec. 31, 2013 Novartis Note [Member] USD ($) | Jan. 31, 2014 Servier Loan [Member] USD ($) | Sep. 30, 2014 Servier Loan [Member] USD ($) | Sep. 30, 2013 Servier Loan [Member] USD ($) | Sep. 30, 2014 Servier Loan [Member] USD ($) | Sep. 30, 2013 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] USD ($) | Dec. 31, 2013 Servier Loan [Member] USD ($) | Dec. 31, 2011 Servier Loan [Member] EUR (€) | Sep. 30, 2014 Servier Loan [Member] Minimum [Member] | Sep. 30, 2014 Servier Loan [Member] Maximum [Member] | Sep. 30, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) Installment | Sep. 30, 2014 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 30, 2013 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 30, 2014 General Electric Capital Corporation Term Loan [Member] USD ($) Installment | Sep. 30, 2013 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2013 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 27, 2012 General Electric Capital Corporation Term Loan [Member] USD ($) | Dec. 31, 2011 General Electric Capital Corporation Term Loan [Member] USD ($) | Sep. 30, 2014 Other [Member] USD ($) | Sep. 30, 2013 Other [Member] USD ($) | Sep. 30, 2014 Other [Member] USD ($) | Sep. 30, 2013 Other [Member] USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date |  |  |  |  |  |  |  | Jun. 30, 2015 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Jun. 15, 2015 |  |  |  |  |  |  |  |
Research and development expenses funded through loan facility, maximum (in hundredths) |  |  |  |  |  |  |  | 75.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum borrowing capacity under loan agreement |  |  |  |  |  | $ 50,000,000 |  | $ 50,000,000 |  |  |  |  |  |  |  |  |  | € 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Variable rate basis |  |  |  |  |  |  |  | six-month LIBOR |  |  |  |  |  | Euro Inter-Bank Offered Rate ("EURIBOR") |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (in hundredths) |  |  |  |  |  |  |  | 2.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate at period end (in hundredths) |  |  |  |  |  | 2.32% |  | 2.32% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Outstanding principal balance |  |  |  |  |  | 13,200,000 |  | 13,200,000 |  | 14,800,000 |  | 19,000,000 |  | 19,000,000 |  |  | 20,600,000 |  |  |  |  | 6,300,000 |  | 6,300,000 |  | 9,400,000 | 3,100,000 | 10,000,000 |  |  |  |
Percentage of milestone received (in hundredths) |  |  |  |  | 25.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone received under the collaboration agreement |  |  |  |  | 7,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repayment of debt |  |  |  |  | 1,750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from loan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 19,500,000 |  |  |  |  | 4,600,000 |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in term loan obligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 12,500,000 |  |  |  |  |  |  |  |  |  |  |
Periodic Payment, Principal |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 347,222 |  |  |  |  |  |  |  |  |  |  |
Initial interest rate during period (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.22% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate reset semi-annually during period (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.39% |  |  |  |  | 2.31% | 3.83% |  |  |  |  |  |  |  |  |  |  |  |
Accrued interest |  |  | 1,628,000 | (2,031,000) |  |  |  |  |  |  | 1,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Euro to US Dollar exchange rates |  |  |  |  |  |  |  |  |  |  |  | 1.2685 |  | 1.2685 |  |  | 1.3766 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate during period (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.31% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unamortized discount on debt |  |  |  |  |  |  |  |  |  |  |  | 8,900,000 |  | 8,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized foreign exchange gain (loss) |  |  | 1,541,000 | 55,000 |  |  |  |  |  |  |  | 200,000 | (800,000) | 200,000 | (500,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization period for loan discount |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  |  |  |  |  |  |  |  |  | 500,000 | 400,000 | 1,400,000 | 1,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Carrying value of the loan |  |  |  |  |  |  |  |  |  |  |  | 16,600,000 |  | 16,600,000 |  |  | 16,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount |  |  |  |  |  |  |  |  |  |  |  | (200,000) | 200,000 | (200,000) | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recognition of deferred revenue |  |  |  |  |  |  |  |  |  |  |  | 500,000 | 400,000 | 1,400,000 | 1,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt issuance costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 |  |  | 1,300,000 |  |  |  |  |  |  |  |
Final payment fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 |  | 500,000 |  |  | 875,000 |  |  |  |  |
Fixed interest rate accrued (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11.71% |  | 11.71% |  |  | 10.90% |  |  |  |  |
Number of monthly installments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 27 |  |  | 42 |  |  |  |  |  |  |  |
Prepayment premium year one (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3.00% |  | 3.00% |  |  |  |  |  |  |  |
Prepayment premium year two (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2.00% |  | 2.00% |  |  |  |  |  |  |  |
Prepayment premium year thereafter (in hundredths) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1.00% |  | 1.00% |  |  |  |  |  |  |  |
Aggregate number of unregistered shares of common stock called by warrants (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 263,158 |  | 263,158 |  |  | 39,346 |  |  |  |  |
Warrants exercise price (in dollars per share) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.14 |  | $ 1.14 |  |  | $ 3.54 |  |  |  |  |
Immediate Term for warrants exercisable (in years) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years |  |  | 5 years |  |  |  |  |  |  |  |
Fair value of warrant liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 |  | 200,000 |  |  | 100,000 |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest expense | $ 1,060,000 | $ 1,159,000 | $ 3,295,000 | $ 3,495,000 |  | $ 79,000 | $ 90,000 | $ 234,000 | $ 272,000 |  |  | $ 583,000 | $ 547,000 | $ 1,770,000 | $ 1,600,000 |  |  |  |  |  |  | $ 398,000 | $ 508,000 | $ 1,268,000 | $ 1,584,000 |  |  |  | $ 0 | $ 14,000 | $ 23,000 | $ 39,000

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- Definition Amount of noncash expense included in interest expense to amortize debt discount and premium associated with the related debt instruments. Excludes amortization of financing costs. Alternate captions include noncash interest expense. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 8 -Article 5 + Details
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- Definition Exercise price per share or per unit of warrants or rights outstanding. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)(4)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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- Definition Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(i)(2)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph i -Subparagraph 2 -Article 4 + Details
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- Definition Percentage points added to the reference rate to compute the variable rate on the debt instrument. + References No definition available. + Details
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- Definition Amount of long-term debt before deduction of unamortized discount or premium. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt, with initial maturities beyond one year or the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 + Details
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- Definition The reference rate for the variable rate of the debt instrument, such as LIBOR or the US Treasury rate and the maturity of the reference rate used, such as three months or six months LIBOR. + References No definition available. + Details
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- Definition Increase for accrued, but unpaid interest on the debt instrument for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(f)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph f -Article 4 + Details
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- Definition The average effective interest rate during the reporting period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28551-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22(a)(1)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28551-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22(a)(1)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Contractual interest rate for funds borrowed, under the debt agreement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22(a)(1)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition The amount of debt discount that was originally recognized at the issuance of the instrument that has yet to be amortized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 45 -Paragraph 1A -URI http://asc.fasb.org/extlink&oid=6451184&loc=d3e28541-108399 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 835 -SubTopic 30 -Section 55 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=34725769&loc=d3e28878-108400 + Details
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- Definition Amount of debt issuance costs (for example, but not limited to, legal, accounting, broker, and regulatory fees). + References No definition available. + Details
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- Definition Carrying amount of long-term debt, net of unamortized discount or premium, including current and noncurrent amounts. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 7 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03.16) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20, 22 -Article 5 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03.16) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 + Details
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- Definition The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References No definition available. + Details
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- Definition The amount of previously reported deferred or unearned revenue that was recognized as revenue during the period. For cash flows, this element primarily pertains to amortization of deferred credits on long-term arrangements. As a noncash item, it is deducted from net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 13.A.4(a).Q1) -URI http://asc.fasb.org/extlink&oid=27012821&loc=d3e214044-122780 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 13 -Section A -Subsection 1 + Details
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- Definition Fair value portion of warrants not settleable in cash classified as equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Amortization period for discount on the liability component of debt. + References No definition available. + Details
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- Definition The maximum percentage of aggregate costs of clinical research and development expenses that are funded through a debt instrument under collaborative arrangements and are not incurred by the Company. + References No definition available. + Details
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- Definition The initial average effective interest rate during the reporting period. + References No definition available. + Details
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- Definition The initial average effective interest rate reset semi annually during the reporting period. + References No definition available. + Details
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- Definition The maximum borrowing capacity for a debt instrument under the loan agreement. + References No definition available. + Details
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- Definition The amount of final payment fee due on maturity of the loan. + References No definition available. + Details
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- Definition Refers to Immediate Term for warrants exercisable before these shares mature. + References No definition available. + Details
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- Definition The cash inflow increase (Decrease) in borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References No definition available. + Details
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- Definition Refers to the timing of required repayments to its customers. + References No definition available. + Details
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- Definition Refers to the payment percentage of milestone received under the collaboration agreement. + References No definition available. + Details
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- Definition The number of monthly installment payments to fully repay the term loan. + References No definition available. + Details
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- Definition Refers to percentage of milestone received. + References No definition available. + Details
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, in the first year of the loan. + References No definition available. + Details
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, thereafter. + References No definition available. + Details
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- Definition The percentage amount of debt premium assessed for voluntarily prepay of the Term Loan in full, but not in part, in the second year of the loan. + References No definition available. + Details
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- Definition The aggregate unrealized foreign currency transaction gain related to the re-measurement of the loan discount. + References No definition available. + Details
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