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Quarterly Financial Information (unaudited) (Details) (USD $) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2014 | Sep. 30, 2014 | Jun. 30, 2014 | Mar. 31, 2014 | Dec. 31, 2013 | Sep. 30, 2013 | Jun. 30, 2013 | Mar. 31, 2013 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
Quarterly Financial Information (unaudited) [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues | $ 4,347,000 us-gaap_Revenues |  | $ 5,136,000 us-gaap_Revenues |  | $ 5,973,000 us-gaap_Revenues |  | $ 3,410,000 us-gaap_Revenues |  | $ 12,535,000 us-gaap_Revenues |  | $ 6,312,000 us-gaap_Revenues |  | $ 7,151,000 us-gaap_Revenues |  | $ 9,453,000 us-gaap_Revenues |  | $ 18,866,000 us-gaap_Revenues | $ 35,451,000 us-gaap_Revenues | $ 33,782,000 us-gaap_Revenues
Total operating costs and expenses | (23,475,000)us-gaap_OperatingExpenses | [1] | (25,589,000)us-gaap_OperatingExpenses | [1] | (24,750,000)us-gaap_OperatingExpenses | [1] | (26,884,000)us-gaap_OperatingExpenses | [1] | (28,114,000)us-gaap_OperatingExpenses |  | (23,535,000)us-gaap_OperatingExpenses |  | (21,230,000)us-gaap_OperatingExpenses |  | (20,777,000)us-gaap_OperatingExpenses |  | (100,698,000)us-gaap_OperatingExpenses | (93,656,000)us-gaap_OperatingExpenses | (90,406,000)us-gaap_OperatingExpenses
Other income (expense), net | 11,810,000 us-gaap_NonoperatingIncomeExpense | [2] | 6,054,000 us-gaap_NonoperatingIncomeExpense | [2] | 6,880,000 us-gaap_NonoperatingIncomeExpense | [2] | 18,787,000 us-gaap_NonoperatingIncomeExpense | [2] | (36,719,000)us-gaap_NonoperatingIncomeExpense | [2] | (12,416,000)us-gaap_NonoperatingIncomeExpense | [2] | (3,169,000)us-gaap_NonoperatingIncomeExpense | [2] | (13,563,000)us-gaap_NonoperatingIncomeExpense | [2] |  |  |
Income tax benefit (expense) | 0 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit |  | (1,000)us-gaap_IncomeTaxExpenseBenefit |  | 15,000 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit |  | 0 us-gaap_IncomeTaxExpenseBenefit | 14,000 us-gaap_IncomeTaxExpenseBenefit | 74,000 us-gaap_IncomeTaxExpenseBenefit
Net loss | (7,318,000)us-gaap_NetIncomeLoss |  | (14,399,000)us-gaap_NetIncomeLoss |  | (11,897,000)us-gaap_NetIncomeLoss |  | (4,687,000)us-gaap_NetIncomeLoss |  | (52,299,000)us-gaap_NetIncomeLoss |  | (29,624,000)us-gaap_NetIncomeLoss |  | (17,248,000)us-gaap_NetIncomeLoss |  | (24,887,000)us-gaap_NetIncomeLoss |  | (38,301,000)us-gaap_NetIncomeLoss | (124,058,000)us-gaap_NetIncomeLoss | (71,065,000)us-gaap_NetIncomeLoss
Basic net loss per share of common stock (in dollars per share) | $ (0.07)us-gaap_EarningsPerShareBasic |  | $ (0.13)us-gaap_EarningsPerShareBasic |  | $ (0.11)us-gaap_EarningsPerShareBasic |  | $ (0.04)us-gaap_EarningsPerShareBasic |  |  |  |  |  |  |  |  |  | $ (0.36)us-gaap_EarningsPerShareBasic | $ (1.43)us-gaap_EarningsPerShareBasic | $ (1.10)us-gaap_EarningsPerShareBasic
Diluted net loss per share of common stock (in dollars per share) | $ (0.12)us-gaap_EarningsPerShareDiluted |  | $ (0.17)us-gaap_EarningsPerShareDiluted |  | $ (0.17)us-gaap_EarningsPerShareDiluted |  | $ (0.21)us-gaap_EarningsPerShareDiluted |  |  |  |  |  |  |  |  |  | $ (0.67)us-gaap_EarningsPerShareDiluted | $ (1.43)us-gaap_EarningsPerShareDiluted | $ (1.10)us-gaap_EarningsPerShareDiluted
Basic and diluted net loss per share of common stock |  |  |  |  |  |  |  |  | $ (0.55)us-gaap_EarningsPerShareBasicAndDiluted |  | $ (0.34)us-gaap_EarningsPerShareBasicAndDiluted |  | $ (0.21)us-gaap_EarningsPerShareBasicAndDiluted |  | $ (0.30)us-gaap_EarningsPerShareBasicAndDiluted |  |  |  |
Restatement Adjustment [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Error Corrections and Prior Period Adjustments Restatement [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease to operating expenses | (1,600,000)xoma_QuantifyingMisstatementInCurrentYearFinancialStatementsAmountOperatingExpenses / us-gaap_StatementScenarioAxis = us-gaap_RestatementAdjustmentMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease to net loss | $ (1,600,000)xoma_QuantifyingMisstatementInCurrentYearFinancialStatementsAmountNetIncomeLoss / us-gaap_StatementScenarioAxis = us-gaap_RestatementAdjustmentMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease to basic loss per share (in dollar per shares) | $ (0.01)xoma_QuantifyingMisstatementInCurrentYearFinancialStatementsEarningsPerShareBasic / us-gaap_StatementScenarioAxis = us-gaap_RestatementAdjustmentMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Decrease to diluted loss per share (in dollar per shares) | $ (0.02)xoma_QuantifyingMisstatementInCurrentYearFinancialStatementsEarningsPerShareDiluted / us-gaap_StatementScenarioAxis = us-gaap_RestatementAdjustmentMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
[1] | In 2014, the Company corrected an immaterial error driven by certain stock-based compensation expense in the fourth quarter of 2014, resulting in a decrease to operating expenses and net loss by $1.6 million and a decrease to basic and diluted loss per share of $0.01 and $0.02, respectively, for the three months ended December 31, 2014. Refer to Note 2, Basis of Presentation and Significant Accounting Policies - Correction of an Immaterial Error
[2] | Fluctuations in 2014 and 2013 primarily relate to (losses) gains on the revaluation of the contingent warrant liabilities.

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