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Capital Stock, Other Offerings and Agreements (Details) (USD $) | 0 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 11 Months Ended | 0 Months Ended | 1 Months Ended |  |
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Mar. 09, 2012 | May 31, 2014 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012 | Jun. 30, 2009 | Dec. 31, 2011 | Dec. 08, 2014 | Dec. 31, 2013 | Aug. 31, 2013 | Oct. 31, 2012 | Feb. 28, 2010 | Aug. 23, 2013 | Oct. 29, 2012
Registered Direct Offerings and Underwritten Offering [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Capital units issued upon the underwriters 30-day over-allotment option (in shares) |  |  |  | 1,425,000 xoma_CapitalUnitsIssuedUponTheUnderwritersAllotmentOption |  |  |  |  | 1,425,000 xoma_CapitalUnitsIssuedUponTheUnderwritersAllotmentOption |  |  |  |  |
Offering expense | $ 3,000,000 xoma_OfferingCosts |  |  |  |  |  |  |  |  |  |  |  |  |
Offering price (in dollars per share) |  |  |  |  |  |  |  | $ 4.94 us-gaap_SharePrice |  |  |  |  |  |
Common stock, shares authorized (in shares) |  | 277,333,332 us-gaap_CommonStockSharesAuthorized | 277,333,332 us-gaap_CommonStockSharesAuthorized | 138,666,666 us-gaap_CommonStockSharesAuthorized |  |  |  |  | 138,666,666 us-gaap_CommonStockSharesAuthorized |  |  |  |  |
Common stock, par value (in dollars per share) |  | $ 0.0075 us-gaap_CommonStockParOrStatedValuePerShare | $ 0.0075 us-gaap_CommonStockParOrStatedValuePerShare | $ 0.0075 us-gaap_CommonStockParOrStatedValuePerShare |  |  |  |  | $ 0.0075 us-gaap_CommonStockParOrStatedValuePerShare |  |  |  |  |
Additional common shares authorized for issuance (in shares) |  | 138,666,666 xoma_NumberOfAdditionalCommonSharesAuthorizedForIssuance |  |  |  |  |  |  |  |  |  |  |  |
ATM Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of common stock |  |  | 41,442,000 us-gaap_ProceedsFromIssuanceOfCommonStock | 84,338,000 us-gaap_ProceedsFromIssuanceOfCommonStock | 76,498,000 us-gaap_ProceedsFromIssuanceOfCommonStock |  |  |  |  |  |  |  |  |
Registered Direct Offerings [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Registered Direct Offerings and Underwritten Offering [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Capital units issued (in shares) |  |  |  |  |  | 695,652 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Common stock per capital unit (in shares) |  |  |  |  |  | 1 xoma_CapitalUnitsIssuedCommonShareComponent / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Common stock per capital unit called by stock warrant (in shares) |  |  |  |  |  | 0.50 xoma_CapitalUnitsIssuedCommonShareComponentCalledByWarrantExercisable / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Gross proceeds from issuance of capital units |  |  |  |  |  | 12,000,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Offering expense |  |  |  |  |  | 800,000 xoma_OfferingCosts / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Purchase price of capital units (in dollars per share) |  |  |  |  |  | $ 17.25 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Number of shares called by warrants (in shares) |  |  |  |  |  | 347,826 us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) |  |  |  |  |  | $ 19.50 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_StatementScenarioAxis = xoma_RegisteredDirectOfferingsMember |  |  |  |  |  |  |  |
2011 ATM Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
ATM Agreement [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock sold (in shares) |  |  |  | 0 us-gaap_StockIssuedDuringPeriodSharesNewIssues / us-gaap_StatementScenarioAxis = xoma_AtmAgreement3Member |  |  | 7,572,327 us-gaap_StockIssuedDuringPeriodSharesNewIssues / us-gaap_StatementScenarioAxis = xoma_AtmAgreement3Member |  |  |  |  |  |  |
Sales commission paid per transaction (in hundredths) |  |  |  |  |  |  | 3.00%xoma_PercentageOfGrossProceedsPaidToAgentForSaleOfCommonShares / us-gaap_StatementScenarioAxis = xoma_AtmAgreement3Member |  |  |  |  |  |  |
Proceeds from issuance of common stock |  |  |  | 500,000 us-gaap_ProceedsFromIssuanceOfCommonStock / us-gaap_StatementScenarioAxis = xoma_AtmAgreement3Member |  |  | 14,600,000 us-gaap_ProceedsFromIssuanceOfCommonStock / us-gaap_StatementScenarioAxis = xoma_AtmAgreement3Member |  |  |  |  |  |  |
Underwritten Offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Registered Direct Offerings and Underwritten Offering [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Capital units issued (in shares) | 29,669,154 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  | 10,925,000 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  | 10,925,000 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  | 2,800,000 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 8,736,187 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 13,333,333 xoma_CapitalUnitsIssued / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember
Capital units issued upon the underwriters 30-day over-allotment option (in shares) |  |  |  |  |  |  |  |  |  |  |  |  | 1,139,502 xoma_CapitalUnitsIssuedUponTheUnderwritersAllotmentOption / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |
Common stock per capital unit (in shares) | 0.5 xoma_CapitalUnitsIssuedCommonShareComponent / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |  | 1 xoma_CapitalUnitsIssuedCommonShareComponent / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  | 1 xoma_CapitalUnitsIssuedCommonShareComponent / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |
Common stock per capital unit called by stock warrant (in shares) |  |  |  |  |  |  |  |  |  |  |  | 0.45 xoma_CapitalUnitsIssuedCommonShareComponentCalledByWarrantExercisable / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |
Gross proceeds from issuance of capital units | 39,200,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |  | 40,000,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 57,400,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 31,600,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 40,000,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | 21,000,000 xoma_GrossProceedsFromIssuanceOfCapitalUnits / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |
Offering expense |  |  |  |  |  |  |  | $ 2,300,000 xoma_OfferingCosts / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | $ 3,800,000 xoma_OfferingCosts / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | $ 2,200,000 xoma_OfferingCosts / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | $ 3,000,000 xoma_OfferingCosts / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |
Purchase price of capital units (in dollars per share) | $ 1.32 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  | $ 5.25 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  | $ 5.25 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  | $ 3.62 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember | $ 3.00 xoma_CapitalUnitsIssuedPricePerUnit / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember
Number of shares called by warrants (in shares) | 14,834,577 us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |  |  |  |  |  |  |  |
Immediate term for warrants exercisable (in years) | 5 years |  |  |  |  |  |  | 2 years |  |  |  |  |  |
Exercise price of warrants (in dollars per share) | $ 1.76 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |  | $ 7.90 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |
Period to purchase additional stock |  |  |  |  |  |  |  |  | 30 days | 30 days |  |  |  |
Warrant outstanding (in shares) | 12,109,418 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |  | 8,097,165 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_StatementScenarioAxis = xoma_UnderwrittenOfferingMember |  |  |  |  |  |

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