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Consolidated Financial Statement Detail (Details) | 12 Months Ended | 1 Months Ended | 12 Months Ended |  |  |  |  |  | 12 Months Ended |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |  |  |  | 12 Months Ended |  |  |  |
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Dec. 31, 2014 USD ($) | Dec. 31, 2013 USD ($) | Dec. 31, 2012 USD ($) | Mar. 31, 2012 Five Year Warrants Issued in February 2010 [Member] | Feb. 28, 2010 Five Year Warrants Issued in February 2010 [Member] USD ($) | Dec. 31, 2014 Five Year Warrants Issued in February 2010 [Member] USD ($) | Dec. 31, 2013 Five Year Warrants Issued in February 2010 [Member] USD ($) | Feb. 28, 2010 Five Year Warrants Issued in February 2010 [Member] | Dec. 31, 2014 Five Year Warrants Issued in March 2012 [Member] USD ($) | Dec. 31, 2013 Five Year Warrants Issued in March 2012 [Member] USD ($) | Mar. 31, 2012 Five Year Warrants Issued in March 2012 [Member] USD ($) | Dec. 31, 2014 Two Year Warrants Issued in December 2014 [Member] USD ($) | Dec. 08, 2014 Two Year Warrants Issued in December 2014 [Member] USD ($) | Jun. 30, 2009 Warrants Issued to Private Investors [Member] USD ($) | Dec. 31, 2014 Warrants Issued to Private Investors [Member] USD ($) | Dec. 31, 2013 Warrants Issued to Private Investors [Member] USD ($) | Jun. 30, 2009 Warrants Issued to Private Investors [Member] | Dec. 31, 2014 Equipment and Furniture [Member] USD ($) | Dec. 31, 2013 Equipment and Furniture [Member] USD ($) | Dec. 31, 2014 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2013 Buildings, Leasehold and Building Improvements [Member] USD ($) | Dec. 31, 2014 Construction-in-Progress [Member] USD ($) | Dec. 31, 2013 Construction-in-Progress [Member] USD ($) | Dec. 31, 2014 Land [Member] USD ($) | Dec. 31, 2013 Land [Member] USD ($) | Dec. 31, 2014 Options Contract [Member] USD ($) Contract | Dec. 31, 2013 Options Contract [Member] USD ($) | Dec. 31, 2012 Options Contract [Member] USD ($) | Dec. 31, 2014 Options Contract [Member] EUR (€) | Dec. 31, 2014 Option Contract 1 [Member] EUR (€) | Dec. 31, 2014 Option Contract 2 [Member] EUR (€) | Dec. 31, 2014 Demand Deposits [Member] USD ($) | Dec. 31, 2013 Demand Deposits [Member] USD ($) | Dec. 31, 2014 Money Market Funds [Member] USD ($) | Dec. 31, 2013 Money Market Funds [Member] USD ($)
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash equivalents |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,800,000 us-gaap_CashEquivalentsAtCarryingValue / us-gaap_CashAndCashEquivalentsAxis = us-gaap_DemandDepositsMember | $ 18,900,000 us-gaap_CashEquivalentsAtCarryingValue / us-gaap_CashAndCashEquivalentsAxis = us-gaap_DemandDepositsMember | $ 67,600,000 us-gaap_CashEquivalentsAtCarryingValue / us-gaap_CashAndCashEquivalentsAxis = us-gaap_MoneyMarketFundsMember | $ 82,800,000 us-gaap_CashEquivalentsAtCarryingValue / us-gaap_CashAndCashEquivalentsAxis = us-gaap_MoneyMarketFundsMember
Short-term Investments [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Short-term investments | 0 us-gaap_ShortTermInvestments | 19,990,000 us-gaap_ShortTermInvestments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Derivative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Notional amount of derivative liability |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 15,000,000 us-gaap_DerivativeLiabilityNotionalAmount / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember |  |  |  |  |  |
Number of foreign exchange option contracts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 us-gaap_DerivativeNumberOfInstrumentsHeld / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember |  |  |  |  |  |  |  |  |
Derivative, amount of hedged item |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 us-gaap_DerivativeAmountOfHedgedItem / us-gaap_DerivativeByNatureAxis = xoma_OptionContractOneMember | 15,000,000 us-gaap_DerivativeAmountOfHedgedItem / us-gaap_DerivativeByNatureAxis = xoma_OptionContractTwoMember |  |  |  |
Derivative, premiums |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 us-gaap_DerivativeCostOfHedge / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember |  |  |  |  |  |  |  |  |
Derivative fair value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 us-gaap_DerivativeAssetFairValueGrossLiability / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember | 400,000 us-gaap_DerivativeAssetFairValueGrossLiability / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember |  |  |  |  |  |  |  |
Derivative, loss |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 us-gaap_DerivativeLossOnDerivative / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember | 100,000 us-gaap_DerivativeLossOnDerivative / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember | 700,000 us-gaap_DerivativeLossOnDerivative / us-gaap_DerivativeByNatureAxis = us-gaap_OptionMember |  |  |  |  |  |  |
Receivables [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Trade receivables, net | 2,993,000 us-gaap_AccountsReceivableNetCurrent | 3,731,000 us-gaap_AccountsReceivableNetCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other receivables | 316,000 us-gaap_OtherReceivablesNetCurrent | 50,000 us-gaap_OtherReceivablesNetCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 3,309,000 us-gaap_ReceivablesNetCurrent | 3,781,000 us-gaap_ReceivablesNetCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property, Plant and Equipment [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, gross | 38,628,000 us-gaap_PropertyPlantAndEquipmentGross | 38,216,000 us-gaap_PropertyPlantAndEquipmentGross |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 28,638,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_FurnitureAndFixturesMember | 28,365,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_FurnitureAndFixturesMember | 9,343,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_BuildingAndBuildingImprovementsMember | 9,316,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_BuildingAndBuildingImprovementsMember | 337,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_ConstructionInProgressMember | 225,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_ConstructionInProgressMember | 310,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_LandMember | 310,000 us-gaap_PropertyPlantAndEquipmentGross / us-gaap_PropertyPlantAndEquipmentByTypeAxis = us-gaap_LandMember |  |  |  |  |  |  |  |  |  |
Less: Accumulated depreciation and amortization | (33,508,000)us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment | (31,760,000)us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment, net | 5,120,000 us-gaap_PropertyPlantAndEquipmentNet | 6,456,000 us-gaap_PropertyPlantAndEquipmentNet |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Depreciation and amortization expense | 1,900,000 us-gaap_DepreciationDepletionAndAmortization | 2,900,000 us-gaap_DepreciationDepletionAndAmortization | 4,100,000 us-gaap_DepreciationDepletionAndAmortization |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued Liabilities [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Incentive compensation | 4,295,000 us-gaap_AccruedBonusesCurrent | 4,386,000 us-gaap_AccruedBonusesCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued payroll and other benefits | 3,061,000 us-gaap_AccruedSalariesCurrent | 3,009,000 us-gaap_AccruedSalariesCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued clinical trial costs | 1,424,000 xoma_AccruedClinicalTrialCosts | 878,000 xoma_AccruedClinicalTrialCosts |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Other | 1,112,000 us-gaap_OtherAccruedLiabilitiesCurrent | 1,661,000 us-gaap_OtherAccruedLiabilitiesCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total | 9,892,000 us-gaap_AccruedLiabilitiesCurrent | 9,934,000 us-gaap_AccruedLiabilitiesCurrent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  |  |  |  |  |  |  | 1,260,000 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedFirstRangeMember | 12,109,418 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember | 12,562,682 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember | 14,834,577 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember |  | 8,097,165 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_TwoYearWarrantsIssuedInDecember2014Member |  |  |  | 347,826 us-gaap_ClassOfWarrantOrRightOutstanding / us-gaap_ClassOfWarrantOrRightAxis = xoma_WarrantsIssuedToPrivateInvestorsMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrants (in dollars per share) |  |  |  |  | $ 10.50 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedFirstRangeMember |  |  |  |  |  | $ 1.76 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember |  | $ 7.90 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_TwoYearWarrantsIssuedInDecember2014Member | $ 19.50 us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_WarrantsIssuedToPrivateInvestorsMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrant liability |  |  |  |  |  |  | 1,100,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedFirstRangeMember |  | 26,700,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember | 68,700,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedSecondRangeMember |  | 5,200,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_TwoYearWarrantsIssuedInDecember2014Member | 10,300,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_TwoYearWarrantsIssuedInDecember2014Member |  | 39,500,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_WarrantsIssuedToPrivateInvestorsMember | 100,000 us-gaap_WarrantsNotSettleableInCashFairValueDisclosure / us-gaap_ClassOfWarrantOrRightAxis = xoma_WarrantsIssuedToPrivateInvestorsMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gain (loss) on revaluation of warrant liability |  |  |  |  |  | $ 1,100,000 us-gaap_FairValueOptionChangesInFairValueGainLoss1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_FiveYearWarrantsIssuedFirstRangeMember |  |  |  |  |  | $ 5,100,000 us-gaap_FairValueOptionChangesInFairValueGainLoss1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_TwoYearWarrantsIssuedInDecember2014Member |  |  | $ 2,500,000 us-gaap_FairValueOptionChangesInFairValueGainLoss1 / us-gaap_ClassOfWarrantOrRightAxis = xoma_WarrantsIssuedToPrivateInvestorsMember |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant term |  |  |  | 5 years | 5 years |  |  |  |  |  |  | 2 years |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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