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Long-Term Debt and Other Financings (Details) $ / shares in Units, € in Millions |  |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jan. 09, 2015 EUR (€) Tranche | Sep. 27, 2012 USD ($) $ / shares shares | Jan. 31, 2015 USD ($) | Jun. 30, 2015 USD ($) $ / shares shares | Jun. 30, 2014 USD ($) | Jun. 30, 2015 USD ($) $ / shares shares | Jun. 30, 2014 USD ($) | Dec. 31, 2011 USD ($) | Feb. 27, 2015 USD ($) | Dec. 31, 2014 USD ($) | Dec. 31, 2011 EUR (€)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Accrued interest |  |  |  |  |  | $ (210,000) | $ 1,570,000 |  |  |  |
Unrealized foreign exchange gain (loss) |  |  |  |  |  | 1,571,000 | 241,000 |  |  |  |
Carrying value of the loan |  |  |  | $ 48,004,000 |  | 48,004,000 |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  |  | (429,000) | 0 |  |  |  |
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] |  |  |  |  |  |  |  |  |  |  |
Six months ending December 31, 2015 |  |  |  | 14,746,000 |  | 14,746,000 |  |  |  |  |
Year ended 2016 |  |  |  | 9,118,000 |  | 9,118,000 |  |  |  |  |
Year ended 2017 |  |  |  | 14,787,000 |  | 14,787,000 |  |  |  |  |
Year ended 2018 |  |  |  | 18,016,000 |  | 18,016,000 |  |  |  |  |
Long-term debt including current portion |  |  |  | 56,667,000 |  | 56,667,000 |  |  |  |  |
Less: Interest, final payment fee, discount and issuance cost |  |  |  | (8,663,000) |  | (8,663,000) |  |  |  |  |
Total long-term |  |  |  | 48,004,000 |  | 48,004,000 |  |  |  |  |
Less: current portion |  |  |  | (15,793,000) |  | (15,793,000) |  |  |  |  |
Total long-term debt |  |  |  | 32,211,000 |  | 32,211,000 |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | 1,007,000 | $ 1,110,000 | $ 2,123,000 | 2,236,000 |  |  |  |
Hercules Loan [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date |  |  |  |  |  | Sep. 01, 2018 |  |  |  |  |
Variable rate basis |  |  |  |  |  | The interest rate will be calculated at a rate equal to the greater of either (i) 9.40% plus the prime rate as reported from time to time in The Wall Street Journal minus 7.25%, and (ii) 9.40%. |  |  |  |  |
Outstanding principal balance |  |  |  | 20,000,000 |  | $ 20,000,000 |  |  |  |  |
Unamortized discount on debt |  |  |  | 0 |  | 0 |  |  |  |  |
Amortization of debt discount |  |  |  | 100,000 |  | 200,000 |  |  |  |  |
Carrying value of the loan |  |  |  | $ 20,000,000 |  | 20,000,000 |  |  | $ 20,000,000 |  |
Debt issuance costs |  |  |  |  |  | $ 500,000 |  |  |  |  |
Aggregate number of unregistered shares of common stock called by warrants (in shares) | shares |  |  |  | 181,268 |  | 181,268 |  |  |  |  |
Warrants exercise price (in dollars per share) | $ / shares |  |  |  | $ 3.31 |  | $ 3.31 |  |  |  |  |
Fair value of warrant liability |  |  |  |  |  |  |  |  | 500,000 |  |
Percentage bearing variable rate (in hundredths) |  |  |  | 9.40% |  | 9.40% |  |  |  |  |
Reduction of percentage of interest under loan agreement (in hundredths) |  |  |  | 7.25% |  | 7.25% |  |  |  |  |
Period of interest |  |  |  |  |  | 1 year |  |  |  |  |
Amortization date |  |  |  |  |  | Jul. 01, 2016 |  |  |  |  |
Date of extension of amortization |  |  |  |  |  | Oct. 01, 2016 |  |  |  |  |
Period of interest amortized |  |  |  |  |  | 30 months |  |  |  |  |
Prepayment fee within twelve months of maturity (in hundredths) |  |  |  |  |  | 3.00% |  |  |  |  |
Prepayment fee after twelve months but before twenty four months of maturity (in hundredths) |  |  |  |  |  | 2.00% |  |  |  |  |
Prepayment fee after twenty four months of maturity (in hundredths) |  |  |  |  |  | 1.00% |  |  |  |  |
Additional interest rate in case of default (in hundredths) |  |  |  |  |  | 5.00% |  |  |  |  |
Final payment fee |  |  |  | $ 1,200,000 |  | $ 1,200,000 |  |  |  |  |
Exercisable period of warrants |  |  |  |  |  | 5 years |  |  |  |  |
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] |  |  |  |  |  |  |  |  |  |  |
Total long-term |  |  |  | 20,000,000 |  | $ 20,000,000 |  |  | $ 20,000,000 |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | 652,000 | 0 | $ 886,000 | 0 |  |  |  |
Servier Loan [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Date of agreement |  |  |  |  |  | Dec. 30, 2010 |  |  |  |  |
Date of agreement, after amendment |  |  |  |  |  | Aug. 12, 2013 |  |  |  |  |
Maximum borrowing capacity under loan agreement | € |  |  |  |  |  |  |  |  |  |  | € 15.0
Period of interest resetting |  |  |  |  |  | 6 months |  |  |  |  |
Outstanding principal balance |  |  |  | $ 16,600,000 |  | $ 16,600,000 |  |  |  | $ 18,200,000 |
Proceeds from loan |  |  |  |  |  |  |  | $ 19,500,000 |  |  |
Initial interest rate during period (in hundredths) |  |  |  |  |  |  |  | 3.22% |  |  |
Interest rate reset semi-annually during period (in hundredths) |  |  |  |  |  | 2.16% |  |  |  |  |
Number of tranches | Tranche | 3 |  |  |  |  |  |  |  |  |  |
Accrued interest |  |  | $ 200,000 |  |  |  |  |  |  |  |
Euro to US Dollar exchange rates |  |  |  | 1.109 |  | 1.109 |  |  |  | 1.216 |
Unamortized discount on debt |  |  |  | $ 8,900,000 |  | $ 8,900,000 |  |  |  |  |
Unrealized foreign exchange gain (loss) |  |  |  | (400,000) | 200,000 | 1,600,000 | 200,000 |  |  |  |
Loan discount balance |  |  |  | 1,900,000 |  | 1,900,000 |  |  |  |  |
Amortization of debt discount |  |  |  | 200,000 | 500,000 | 300,000 | 900,000 |  |  |  |
Carrying value of the loan |  |  |  | 15,200,000 |  | 15,200,000 |  |  |  | $ 16,200,000 |
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount |  |  |  | (35,000) | (26,000) | 200,000 | (32,000) |  |  |  |
Recognition of deferred revenue |  |  |  | 200,000 | 500,000 | 300,000 | 900,000 |  |  |  |
Debt issuance costs |  |  |  |  |  | 6,000 |  |  |  |  |
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] |  |  |  |  |  |  |  |  |  |  |
Total long-term |  |  |  | 15,200,000 |  | 15,200,000 |  |  |  | 16,200,000 |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | $ 272,000 | 600,000 | $ 527,000 | 1,188,000 |  |  |  |
Servier Loan [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Interest rate reset semi-annually during period (in hundredths) |  |  |  |  |  | 2.31% |  |  |  |  |
Servier Loan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Interest rate reset semi-annually during period (in hundredths) |  |  |  |  |  | 3.83% |  |  |  |  |
Servier Loan [Member] | Tranche One [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2016 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € | € 3.0 |  |  |  |  |  |  |  |  |  |
Servier Loan [Member] | Tranche Two [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2017 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € | € 5.0 |  |  |  |  |  |  |  |  |  |
Servier Loan [Member] | Tranche Three [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2018 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € | € 7.0 |  |  |  |  |  |  |  |  |  |
General Electric Capital Corporation Term Loan [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Outstanding principal balance |  |  |  |  |  |  |  | $ 10,000,000 |  |  |
Aggregate number of unregistered shares of common stock called by warrants (in shares) | shares |  | 39,346 |  | 263,158 |  | 263,158 |  |  |  |  |
Warrants exercise price (in dollars per share) | $ / shares |  | $ 3.54 |  | $ 1.14 |  | $ 1.14 |  |  |  |  |
Immediate Term for warrants exercisable (in years) |  | 5 years |  |  |  | 5 years |  |  |  |  |
Fair value of warrant liability |  | $ 100,000 |  |  |  |  |  | $ 200,000 |  |  |
Loss on extinguishment of debt |  |  |  |  |  | $ 400,000 |  |  |  |  |
Outstanding principle balance and interest |  |  |  |  |  | 5,500,000 |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | $ 0 | 423,000 | $ 548,000 | 870,000 |  |  |  |
Novartis Note [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date |  |  |  |  |  | Jun. 30, 2015 |  |  |  |  |
Research and development expenses funded through loan facility, maximum (in hundredths) |  |  |  |  |  | 75.00% |  |  |  |  |
Maximum borrowing capacity under loan agreement |  |  |  | $ 50,000,000 |  | $ 50,000,000 |  |  |  |  |
Interest rate at period end (in hundredths) |  |  |  | 2.44% |  | 2.44% |  |  |  |  |
Outstanding principal balance |  |  |  | $ 13,500,000 |  | $ 13,500,000 |  |  |  | $ 13,400,000 |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | 80,000 | 78,000 | $ 159,000 | 155,000 |  |  |  |
Novartis Note [Member] | LIBOR [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Basis spread on variable rate (in hundredths) |  |  |  |  |  | 2.00% |  |  |  |  |
Other [Member] |  |  |  |  |  |  |  |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |  |  |  |  |  |  |  |
Interest expense |  |  |  | $ 3,000 | $ 9,000 | $ 3,000 | $ 23,000 |  |  |  |

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