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Condensed Consolidated Financial Statements Detail (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Mar. 31, 2012 | Feb. 28, 2010 | Jun. 30, 2015 | Jun. 30, 2014 | Jun. 30, 2015 | Jun. 30, 2014 | Dec. 31, 2014
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |  |  |  |  |  |  |  |
Antidilutive securities excluded from computation of earnings per share (in shares) |  |  | 27,449,000 | 9,849,000 | 26,937,000 | 8,486,000 |  |
Numerator [Abstract] |  |  |  |  |  |  |  |
Net loss, Basic |  |  | $ (23,759) | $ (11,897) | $ (45,477) | $ (16,584) |  |
Adjustment for revaluation of contingent warrant liabilities |  |  | 0 | (7,616) | 0 | (27,150) |  |
Net loss, Diluted |  |  | $ (23,759) | $ (19,513) | $ (45,477) | $ (43,734) |  |
Denominator Abstract] |  |  |  |  |  |  |  |
Weighted average shares outstanding used for basic net loss per share (in shares) |  |  | 117,540,000 | 106,927,000 | 116,870,000 | 106,545,000 |  |
Effect of dilutive warrants (in shares) |  |  | 0 | 7,199,000 | 0 | 8,503,000 |  |
Weighted average shares outstanding and dilutive securities used for diluted net loss per share (in shares) |  |  | 117,540,000 | 114,126,000 | 116,870,000 | 115,048,000 |  |
Accrued and other liabilities [Abstract] |  |  |  |  |  |  |  |
Accrued payroll and other benefits |  |  | $ 2,851 |  | $ 2,851 |  | $ 3,061 |
Accrued management incentive compensation |  |  | 2,300 |  | 2,300 |  | 4,295 |
Accrued clinical trial costs |  |  | 1,081 |  | 1,081 |  | 1,424 |
Other |  |  | 1,209 |  | 1,209 |  | 1,112 |
Total |  |  | $ 7,441 |  | 7,441 |  | $ 9,892 | [1]
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |
Reclassification of contingent warrant liability to equity upon exercise of warrants |  |  |  |  | $ 3,088 | $ 2,526 |  |
Cashless exercise of warrants (in shares) |  |  | 1,602,575 |  | 1,602,575 |  |  |
Two Year Warrants Issued in December 2014 [Member] |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  |  | 8,097,165 |  | 8,097,165 |  | 8,097,165 |
Exercise price of warrants (in dollars per share) |  |  |  |  |  |  | $ 7.90 |
Fair value of warrant liability |  |  | $ 4,000 |  | $ 4,000 |  | $ 5,200 |
Gain (loss) on revaluation of warrant liability |  |  |  |  | $ 1,200 |  |  |
Warrant term |  |  |  |  |  |  | 2 years |
Five Year Warrants Issued in March 2012 [Member] |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |
Warrants outstanding (in shares) | 14,834,577 |  | 10,506,093 |  | 10,506,093 |  | 12,109,418 |
Exercise price of warrants (in dollars per share) | $ 1.76 |  |  |  |  |  |  |
Fair value of warrant liability |  |  | $ 25,000 |  | $ 25,000 |  | $ 26,700 |
Gain (loss) on revaluation of warrant liability |  |  |  |  | (1,400) |  |  |
Gain (loss) on revaluation of warrant liability related to exercised warrants |  |  |  |  | $ 500 |  |  |
Warrant term | 5 years |  |  |  |  |  |  |
Warrants exercise (in shares) |  |  | 1,603,325 |  | 1,603,325 |  |  |
Five Year Warrants Issued in February 2010 [Member] |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |
Warrants outstanding (in shares) |  | 1,260,000 |  |  |  |  |  |
Exercise price of warrants (in dollars per share) |  | $ 10.50 |  |  |  |  |  |
Warrant term |  | 5 years |  |  |  |  |  |
Warrants Issued to Private Investors [Member] |  |  |  |  |  |  |  |
Class of Warrant or Right [Line Items] |  |  |  |  |  |  |  |
Warrants issued (in shares) |  |  | 855,128 |  | 855,128 |  |  |
Demand Deposits [Member] |  |  |  |  |  |  |  |
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |
Cash equivalents |  |  | $ 18,900 |  | $ 18,900 |  | 10,800 |
Money Market Funds [Member] |  |  |  |  |  |  |  |
Cash and Cash Equivalents [Line Items] |  |  |  |  |  |  |  |
Cash equivalents |  |  | $ 32,100 |  | $ 32,100 |  | $ 67,600 |
Common Stock Options and Restricted Stock [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |  |  |  |  |  |  |  |
Antidilutive securities excluded from computation of earnings per share (in shares) |  |  | 8,362,000 | 7,939,000 | 7,850,000 | 6,576,000 |  |
Warrants for Common Stock [Member] |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] |  |  |  |  |  |  |  |
Antidilutive securities excluded from computation of earnings per share (in shares) |  |  | 19,087,000 | 1,910,000 | 19,087,000 | 1,910,000 |  |
[1] | The condensed consolidated balance sheet as of December 31, 2014 has been derived from the audited consolidated financial statements as of that date included in the Company's Annual Report on Form 10-K for the year ended December 31, 2014.

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