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Description of Business - Additional Information (Details) - USD ($) $ in Thousands | 9 Months Ended |  |  |
--- | --- | --- | --- | ---
Sep. 30, 2015 | Dec. 31, 2014 | Sep. 30, 2014 | Dec. 31, 2013
Description Of Business [Line Items] |  |  |  |  |
Accumulated deficit | $ (1,165,435) | $ (1,119,477) | [1] |  |
Cash and cash equivalents | 32,046 | 78,445 | [1] | $ 54,060 | $ 101,659
Novartis Note [Member] |  |  |  |  |
Description Of Business [Line Items] |  |  |  |  |
Outstanding principal balance | $ 13,500 | $ 13,400 |  |  |
Maturity date | Jun. 30, 2015 |  |  |  |
Collaborative Arrangement | Novartis Note [Member] |  |  |  |  |
Description Of Business [Line Items] |  |  |  |  |
Upfront payment received | $ 37,000 |  |  |  |
Outstanding principal balance | $ 13,500 |  |  |  |
Maturity date | Sep. 30, 2020 |  |  |  |
[1] | The condensed consolidated balance sheet as of December 31, 2014 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2014.

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