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Quarterly Financial Information (unaudited) (Parenthetical) (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2015
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Gain on sale of business |  |  | $ 3,505
Restatement Adjustment [Member] |  |  |
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Decrease to operating expenses |  | $ (1,600) |
Decrease to net loss |  | $ (1,600) |
Decrease to basic loss per share (in dollar per shares) |  | $ (0.01) |
Decrease to diluted loss per share (in dollar per shares) |  | $ (0.02) |
Manufacturing Facility in Berkeley, California [Member] | Other Income (Expense), Net [Member] |  |  |
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Gain on sale of business | $ 3,500 |  |
Novartis [Member] |  |  |
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Upfront payment received | 37,000 |  |
Novo Nordisk [Member] |  |  |
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Upfront payment received | 5,000 |  |
Pfizer [Member] |  |  |
Error Corrections And Prior Period Adjustments Restatement [Line Items] |  |  |
Upfront payment received | $ 3,800 |  |

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