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Consolidated Financial Statement Detail - Accrued and other liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
--- | --- | --- | ---
Accrued and other liabilities [Abstract] |  |  |
Accrued management incentive compensation | $ 2,609 | $ 4,295 |
Accrued payroll and other benefits | 2,156 | 3,061 |
Accrued legal and accounting fees | 517 | 409 |
Accrued restructuring costs | 459 |  | $ 21
Accrued clinical trial costs | 406 | 1,424 |
Other | 878 | 703 |
Total | $ 7,025 | $ 9,892 |

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