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v3.3.1.900

Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details) $ in Thousands |  | 1 Months Ended | 6 Months Ended | 12 Months Ended | 44 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jan. 09, 2015 USD ($) Tranche | Jan. 31, 2016 USD ($) | Jan. 31, 2011 USD ($) | Jul. 31, 2015 | Jul. 31, 2011 | Dec. 31, 2015 USD ($) € / $ | Dec. 31, 2014 USD ($) € / $ | Dec. 31, 2013 USD ($) | Jan. 31, 2015 | Dec. 31, 2015 EUR (€) € / $ | Jan. 09, 2015 EUR (€) Tranche
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Accrued interest paid |  |  |  |  |  | $ 1,927 | $ 3,009 | $ 1,262 |  |  |
Carrying value of the loan |  |  |  |  |  | 48,667 | 35,308 |  |  |  |
Unrealized foreign exchange gain (loss) |  |  |  |  |  | $ 1,870 | 2,280 | (662) |  |  |
Servier Loan [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Date of agreement |  |  |  |  |  | Dec. 30, 2010 |  |  |  |  |
Maximum borrowing capacity under loan agreement | € |  |  |  |  |  |  |  |  |  | € 15,000,000 |
Proceeds from loan |  |  | $ 19,500 |  |  |  |  |  |  |  |
Interest rate during period |  |  |  |  | 3.22% |  |  |  |  |  |
Interest rates reset semi-annually, minimum |  |  |  |  |  |  |  |  | 2.05% |  |
Interest rates reset semi-annually, maximum |  |  |  |  |  |  |  |  | 3.83% |  |
Date of loan amendment |  |  |  |  |  | Jan. 09, 2015 |  |  |  |  |
Date of agreement, after amendment |  |  |  |  |  | Aug. 12, 2013 |  |  |  |  |
Number of tranches | Tranche | 3 |  |  |  |  |  |  |  |  |  | 3
Unamortized discount on debt | $ 1,900 |  | $ 8,900 |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  |  |  | $ 700 | 1,900 | 1,600 |  |  |
Carrying value of the loan |  |  |  |  |  | 15,300 | 16,200 |  |  |  |
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount |  |  |  |  |  | $ (200) | (300) | 200 |  |  |
Agreement termination date |  |  |  |  |  | Sep. 28, 2015 |  |  |  |  |
Agreement termination notice period |  |  |  |  |  | 180 days |  |  |  |  |
Outstanding principal balance |  |  |  |  |  | $ 16,400 | $ 18,200 |  |  |  |
Euro to US Dollar exchange rates | € / $ |  |  |  |  |  | 1.091 | 1.216 |  |  | 1.091 |
Unrealized foreign exchange gain (loss) |  |  |  |  |  | $ 1,900 | $ 2,400 | $ (800) |  |  |
Servier Loan [Member] | Tranche One [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2016 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  | € 3,000,000
Servier Loan [Member] | Tranche Two [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2017 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  | 5,000,000
Servier Loan [Member] | Tranche Three [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2018 |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  | € 7,000,000
Servier Loan [Member] | Subsequent Event |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Accrued interest paid |  | $ 200 |  |  |  |  |  |  |  |  |
Servier Loan [Member] | Mid-January 2015 Through Mid-July 2015 [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Interest rate during period |  |  |  | 2.16% |  |  |  |  |  |  |
Period of interest resetting |  |  |  |  |  | 6 months |  |  |  |  |
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member] |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |
Interest rate during period |  |  |  |  |  | 2.05% |  |  |  |  |
Period of interest resetting |  |  |  |  |  | 6 months |  |  |  |  |

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