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Concentration of Risk, Segment and Geographic Information - Revenue by Geographical Region (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2015 | [1] | Sep. 30, 2015 | [1] | Jun. 30, 2015 | [1] | Mar. 31, 2015 | [1] | Dec. 31, 2014 | Sep. 30, 2014 | Jun. 30, 2014 | Mar. 31, 2014 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues | $ 48,183 | $ 2,074 | $ 2,539 | $ 2,651 | $ 4,347 | $ 5,136 | $ 5,973 | $ 3,410 | $ 55,447 | $ 18,866 | $ 35,451
United States [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 10,685 | 11,756 | 19,955
Europe [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 44,662 | 5,510 | 15,396
Asia Pacific [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues from External Customers and Long-Lived Assets [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | $ 100 | $ 1,600 | $ 100
[1] | In the fourth quarter of 2015, the total revenues include upfront and milestone payments relating to various out-licensing arrangements, including a $37.0 million upfront payment from Novartis, a $5.0 million upfront payment from Novo Nordisk and a $3.8 million payment from Pfizer.

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