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Long-Term Debt and Other Financings - Novartis Note - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Jan. 31, 2014 | May. 31, 2005 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Novartis Note [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date |  | Jun. 30, 2015 |  |  |
Research and development expenses funded through loan facility, maximum |  | 75.00% |  |  |
Maximum borrowing capacity under loan agreement |  | $ 50,000,000 |  |  |
Interest rate at period end |  |  | 2.81% |  |
Accrued interest payable |  |  | $ 300,000 | $ 300,000 | $ 400,000
Percentage of milestone received | 25.00% |  |  |  |
Milestone received under the collaboration agreement | $ 7,000,000 |  |  |  |
Repayment of debt | $ 1,750,000 |  |  |  |
Outstanding principal balance |  |  | $ 13,700,000 | $ 13,400,000 |
Novartis Note [Member] | Six-month LIBOR [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Basis spread on variable rate |  |  | 2.00% |  |
Secured Note Amendment [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date |  |  | Sep. 30, 2020 |  |
Reduction in outstanding principal amount |  |  | $ 7,300,000 |  |

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- Definition Amount of long-term debt before deduction of unamortized discount or premium. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt, with initial maturities beyond one year or the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 + Details
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