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Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | $ 4,194 | $ 4,303 | $ 4,631
Hercules Loan [Member] |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | 2,223 |  |
Servier Loan [Member] |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | 1,083 | 2,330 | 2,152
GECC Term Loan [Member] |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | 548 | 1,638 | 2,064
Novartis Note [Member] |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | 329 | 312 | 362
Other [Member] |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |
Interest expense | $ 11 | $ 23 | $ 53

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- References No definition available. + Details
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- Definition Amount of the cost of borrowed funds accounted for as interest expense for debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 + Details
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