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Collaborative, Licensing and Other Arrangements - Novo Nordisk - Additional Information (Details) - USD ($) | 3 Months Ended | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Performance deliverable period for license and transfer of technology and knowhow |  | 60 days
Upfront payment recognized as revenue |  | $ 5,000,000
Novo Nordisk [Member] |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Upfront payment received | $ 5,000,000 |
Agreement termination notice period |  | 90 days
Collaborative Arrangement [Member] | Novo Nordisk [Member] |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Upfront payment received |  | $ 5,000,000
Eligible milestone payments receivable upon achievement of development, regulatory and commercial milestones |  | 290,000,000
Milestone received under the collaboration agreement |  | $ 0

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