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Long-Term Debt and Other Financings (Tables) | 12 Months Ended
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Dec. 31, 2015
Debt Disclosure [Abstract] |
Aggregate future principal and final fee payments of interest bearing obligations | Aggregate future principal, final fee payments and discounts of the Company’s total interest bearing obligations as of December 31, 2015 are as follows (in thousands):
Year Ended December 31, |  | Amounts |
2016 |  | $ | 9,038 |
2017 |  |  | 14,677 |
2018 |  |  | 17,879 |
2019 |  |  | — |
2020 |  |  | 15,664 |
|  |  | 57,258 |
Less: Interest, final payment fee, discount and issuance cost |  |  | (8,591 | )
|  |  | 48,667 |
Less: interest bearing obligations – current |  |  | (5,910 | )
Interest bearing obligations – non-current |  | $ | 42,757 |
Interest expense and amortization of debt issuance costs | Amortization of debt issuance costs and discounts are included in interest expense. Interest expense in the consolidated statements of comprehensive loss for the years ended December 31, 2015, 2014, and 2013 relates to the following debt instruments (in thousands):
|  | Year Ended December 31, |
|  | 2015 |  |  | 2014 |  |  | 2013 |
Hercules loan |  | $ | 2,223 |  |  | $ | — |  |  | $ | — |
Servier loan |  |  | 1,083 |  |  |  | 2,330 |  |  |  | 2,152 |
GECC term loan |  |  | 548 |  |  |  | 1,638 |  |  |  | 2,064 |
Novartis note |  |  | 329 |  |  |  | 312 |  |  |  | 362 |
Other |  |  | 11 |  |  |  | 23 |  |  |  | 53 |
Total interest expense |  | $ | 4,194 |  |  | $ | 4,303 |  |  | $ | 4,631 |

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- Definition Tabular disclosure of the combined aggregate amount of maturities and sinking fund requirements for all long-term borrowings for each of the five years following the date of the latest balance sheet date presented. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6802200&loc=d3e1835-112601 + Details
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