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Description of Business - Additional Information (Details) - USD ($) $ in Thousands | 1 Months Ended |
--- | --- | ---
Mar. 31, 2016 | Dec. 31, 2015 | [1]
Description Of Business [Line Items] |  |
Accumulated deficit | $ (1,148,448) | $ (1,140,083)
Cash, cash equivalents and marketable securities | $ 46,600 |
Servier [Member] |  |
Description Of Business [Line Items] |  |
Collaboration agreement termination date | Mar. 26, 2016 |
[1] | The condensed consolidated balance sheet as of December 31, 2015 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2015.

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- Definition The cumulative amount of the reporting entity's undistributed earnings or deficit. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.31(a)(3)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 04 -Article 3 + Details
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