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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2016 | Mar. 31, 2015
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | $ 1,002 | $ 1,115
Hercules Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | 672 | 234
Servier Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | 226 | 255
GECC Term Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense |  | 548
Novartis Note [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | 97 | $ 78
Other [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | $ 7 |

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- References No definition available. + Details
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- Definition Amount of the cost of borrowed funds accounted for as interest expense for debt. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688 + Details
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