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Long-Term Debt - Servier Loan Agreement - Additional Information (Details) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |
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Jan. 09, 2015 USD ($) Tranche | Jan. 31, 2016 EUR (€) | Jan. 31, 2011 USD ($) | Jun. 30, 2016 USD ($) € / $ | Jun. 30, 2015 USD ($) | Jul. 31, 2016 | Jun. 30, 2016 USD ($) € / $ | Jun. 30, 2015 USD ($) | Jul. 31, 2011 | Jul. 15, 2016 | Jun. 30, 2016 EUR (€) € / $ | Dec. 31, 2015 USD ($) € / $ | Jan. 09, 2015 EUR (€) Tranche
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued interest paid |  |  |  |  |  |  | $ 1,127,000 | $ 792,000 |  |  |  |  |
Carrying value of the loan |  |  |  | $ 46,524,000 |  |  | $ 46,524,000 |  |  |  |  | $ 48,667,000 |
Servier Loan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Date of agreement |  |  |  |  |  |  | Dec. 30, 2010 |  |  |  |  |  |
Maximum borrowing capacity under loan agreement | € |  |  |  |  |  |  |  |  |  |  | € 15,000,000 |  |
Proceeds from loan |  |  | $ 19,500,000 |  |  |  |  |  |  |  |  |  |
Interest rate during period |  |  |  |  |  |  |  |  | 3.22% |  |  |  |
Date of loan amendment |  |  |  |  |  |  | Jan. 09, 2015 |  |  |  |  |  |
Date of agreement, after amendment |  |  |  |  |  |  | Aug. 12, 2013 |  |  |  |  |  |
Number of tranches | Tranche | 3 |  |  |  |  |  |  |  |  |  |  |  | 3
Principal payment amount | € |  | € 3,000,000 |  |  |  |  |  |  |  |  |  |  |
Accrued interest paid | € |  | € 200,000 |  |  |  |  |  |  |  |  |  |  |
Unamortized discount on debt | $ 1,900,000 |  | $ 8,900,000 |  |  |  |  |  |  |  |  |  |
Amortization of debt discount |  |  |  | 200,000 | $ 200,000 |  | $ 300,000 | 300,000 |  |  |  |  |
Carrying value of the loan |  |  |  | 12,600,000 |  |  | 12,600,000 |  |  |  |  | 15,300,000 |
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount |  |  |  | (17,000) | 35,000 |  | $ 20,000 | (200,000) |  |  |  |  |
Agreement termination date |  |  |  |  |  |  | Sep. 28, 2015 |  |  |  |  |  |
Agreement termination notice period |  |  |  |  |  |  | 180 days |  |  |  |  |  |
Outstanding principal balance |  |  |  | $ 13,300,000 |  |  | $ 13,300,000 |  |  |  |  | $ 16,400,000 |
Euro to US Dollar exchange rates | € / $ |  |  |  | 1.110 |  |  | 1.110 |  |  |  | 1.110 | 1.091 |
Unrealized foreign exchange gains (loss) related to re-measurement of loan |  |  |  | $ 300,000 | $ (400,000) |  | $ (200,000) | $ 1,600,000 |  |  |  |  |
Servier Loan [Member] | Tranche One [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2016 |  |  |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  |  |  | € 3,000,000
Servier Loan [Member] | Tranche Two [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2017 |  |  |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  |  |  | 5,000,000
Servier Loan [Member] | Tranche Three [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Maturity date | Jan. 15, 2018 |  |  |  |  |  |  |  |  |  |  |  |
Principal payment amount | € |  |  |  |  |  |  |  |  |  |  |  |  | € 7,000,000
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate during period |  |  |  |  |  |  | 2.05% |  |  |  |  |  |
Period of interest resetting |  |  |  |  |  |  | 6 months |  |  |  |  |  |
Servier Loan [Member] | Subsequent Event [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rates reset semi-annually |  |  |  |  |  |  |  |  |  | 1.95% |  |  |
Servier Loan [Member] | Subsequent Event [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rates reset semi-annually |  |  |  |  |  |  |  |  |  | 3.83% |  |  |
Servier Loan [Member] | Subsequent Event [Member] | Mid-January 2016 Through Mid-July 2016 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Interest rate during period |  |  |  |  |  | 1.95% |  |  |  |  |  |  |
Period of interest resetting |  |  |  |  |  | 6 months |  |  |  |  |  |  |

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