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Stock-based Compensation (Tables) | 6 Months Ended
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Jun. 30, 2016
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Weighted Average Assumptions | The fair value of the stock options granted during the three and six months ended June 30, 2016 and 2015, was estimated based on the following weighted average assumptions:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2016 |  |  | 2015 |  |  | 2016 |  |  | 2015 |
Dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected volatility |  |  | 107 | % |  |  | 81 | % |  |  | 107 | % |  |  | 82 | %
Risk-free interest rate |  |  | 1.01 | % |  |  | 1.65 | % |  |  | 1.18 | % |  |  | 1.40 | %
Expected term |  | 5.6 years |  |  | 5.6 years |  |  | 5.6 years |  |  | 5.6 years |
Stock Option Activity | Stock option activity for the six months ended June 30, 2016, was as follows:
|  | Options |  |  | Weighted Average Exercise Price Per Share |  |  | Weighted Average Remaining Contractual Life (in years) |  |  | Aggregate Intrinsic Value (in thousands) |
Outstanding at January 1, 2016 |  |  | 7,690,297 |  |  | $ | 6.33 |  |  |  |  |  |  |  |  |
Granted |  |  | 99,300 |  |  |  | 0.93 |  |  |  |  |  |  |  |  |
Forfeited, expired or cancelled |  |  | (628,182 | ) |  |  | 6.48 |  |  |  |  |  |  |  |  |
Outstanding at June 30, 2016 |  |  | 7,161,415 |  |  | $ | 6.24 |  |  |  | 6.17 |  |  | $ | — |
Vested and expected to vest at June 30, 2016 |  |  | 7,026,845 |  |  | $ | 6.28 |  |  | 6.11 |  |  | $ | — |
Exercisable at June 30, 2016 |  |  | 5,775,398 |  |  | $ | 6.59 |  |  |  | 5.65 |  |  | $ | — |
Unvested RSU Activity | Unvested RSU activity for the six months ended June 30, 2016, is summarized below:
|  |  |  |  |  | Weighted- |
|  | Number of |  |  | Average Grant- |
|  | Shares |  |  | Date Fair Value |
Unvested balance at January 1, 2016 |  |  | 2,125,761 |  |  | $ | 4.07 |
Granted |  |  | 2,302,944 |  |  |  | 0.76 |
Vested |  |  | (1,132,525 | ) |  |  | 3.27 |
Forfeited |  |  | (298,228 | ) |  |  | 2.87 |
Unvested balance at June 30, 2016 |  |  | 2,997,952 |  |  | $ | 1.95 |
Stock-based Compensation expense | The following table shows total stock-based compensation expense for stock options, RSUs and ESPP in the condensed consolidated statements of comprehensive loss (in thousands):
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2016 |  |  | 2015 |  |  | 2016 |  |  | 2015 |
Research and development |  | $ | 857 |  |  | $ | 1,399 |  |  | $ | 1,994 |  |  | $ | 3,595 |
Selling, general and administrative |  |  | 1,308 |  |  |  | 1,290 |  |  |  | 2,477 |  |  |  | 2,759 |
Total stock-based compensation expense |  | $ | 2,165 |  |  | $ | 2,689 |  |  | $ | 4,471 |  |  | $ | 6,354 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock units. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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