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Description of Business - Additional Information (Details) - USD ($) $ in Thousands | 3 Months Ended |  |  |
--- | --- | --- | --- | ---
Jun. 30, 2017 | Dec. 31, 2016 | [1] | Jun. 30, 2016 | Dec. 31, 2015
Description Of Business [Line Items] |  |  |  |
Accumulated deficit | $ 1,204,084 | $ 1,193,613 |  |
Working capital | 1,700 |  |  |
Carrying value of the loan | 27,861 |  |  |
Cash and cash equivalents | 12,465 | $ 25,742 | $ 33,854 | $ 65,767
Novartis [Member] | Collaborative Arrangement [Member] |  |  |  |
Description Of Business [Line Items] |  |  |  |
Milestone received under the collaboration agreement | $ 10,000 |  |  |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016.

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3044-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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