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Income Taxes - Components of Net Deferred Tax Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
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Components Of Deferred Tax Assets [Abstract] |  |
Capitalized research and development expenses | $ 26,367 | $ 53,557
Net operating loss carryforwards | 4,701 | 123,672
Research and development and other credit carryforwards | 12,225 | 25,297
Stock compensation | 3,680 | 7,099
Deferred revenue | 3,928 | 6,577
Other | 883 | 1,724
Total deferred tax assets | 51,784 | 217,926
Valuation allowance | $ (51,784) | $ (217,926)

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