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Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details) |  |  | 1 Months Ended | 12 Months Ended |  |
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Aug. 25, 2017 USD ($) € / $ | Jan. 09, 2015 EUR (€) Tranche | Jan. 31, 2017 EUR (€) | Jan. 31, 2016 EUR (€) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) € / $ | Dec. 31, 2015 USD ($) | Dec. 31, 2017 EUR (€) | Jan. 31, 2011 USD ($)
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Accrued interest paid |  |  |  |  | $ 545,000 | $ 2,142,000 | $ 1,927,000 |  |
Loss on extinguishment of debt |  |  |  |  | $ 650,000 |  | 429,000 |  |
Servier Loan [Member] |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Date of agreement |  |  |  |  | Dec. 30, 2010 |  |  |  |
Maximum borrowing capacity under loan agreement | € |  |  |  |  |  |  |  | € 15,000,000 |
Proceeds from loan |  |  |  |  | $ 19,500,000 |  |  |  |
Date of loan amendment |  |  |  |  | Jan. 09, 2015 |  |  |  |
Number of tranches | Tranche |  | 3 |  |  |  |  |  |  |
Principal payment amount | € |  |  |  | € 3,000,000 |  |  |  |  |
Accrued interest paid | € |  |  |  | € 200,000 |  |  |  |  |
Unamortized discount on debt |  |  |  |  |  |  |  |  | $ 8,900,000
Amortization of debt discount |  |  |  |  | $ 400,000 | 600,000 | 700,000 |  |
Carrying value of the loan |  |  |  |  |  | 12,200,000 |  |  |
Unrealized foreign exchange gain (losses) related to re-measurement of loan discount |  |  |  |  |  | 5,000 | (200,000) |  |
Outstanding principal balance |  |  |  |  |  | $ 12,600,000 |  |  |
Euro to US Dollar exchange rates | € / $ | 1.1932 |  |  |  |  | 1.052 |  |  |
Unrealized foreign exchange gains (loss) related to re-measurement of loan |  |  |  |  |  | $ 500,000 | $ 1,900,000 |  |
Payment of debt through cash by NIBR | $ 14,300,000 |  |  |  |  |  |  |  |
Loss on extinguishment of debt |  |  |  |  | $ 100,000 |  |  |  |
Servier Loan [Member] | Tranche One [Member] |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Maturity date |  | Jan. 15, 2016 |  |  |  |  |  |  |
Principal payment amount | € |  | € 3,000,000 |  |  |  |  |  |  |
Servier Loan [Member] | Tranche Two [Member] |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Maturity date |  | Jan. 15, 2017 |  |  |  |  |  |  |
Principal payment amount | € |  | € 5,000,000 |  |  |  |  |  |  |
Servier Loan [Member] | Tranche Two [Member] | Amendment No.3 [Member] |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Maturity date |  |  | Jul. 15, 2017 |  |  |  |  |  |
Principal payment amount | € |  |  | € 5,000,000 |  |  |  |  |  |
Servier Loan [Member] | Tranche Three [Member] |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |
Maturity date |  | Jan. 15, 2018 |  |  |  |  |  |  |
Principal payment amount | € |  | € 7,000,000 |  |  |  |  |  |  |

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