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Compensation and Other Benefit Plans (Tables) | 12 Months Ended
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Dec. 31, 2017
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Stock Option Activity | The following table summarizes the Company’s stock option activity for the year ended December 31, 2017:
|  | Number of shares |  |  | Weighted Average Exercise Price Per Share |
Outstanding at beginning of year |  |  | 568,292 |  |  | $ | 77.70 |
Granted |  |  | 1,387,820 |  |  |  | 10.94 |
Exercised |  |  | (110,400 | ) |  |  | 5.95 |
Forfeited, expired or cancelled |  |  | (223,647 | ) |  |  | 84.40 |
Outstanding at end of year |  |  | 1,622,065 |  |  | $ | 24.54 |
Exercisable at end of year |  |  | 849,279 |  |  | $ | 32.79 |
Unvested RSU Activity | Unvested RSU activity for the year ended December 31, 2017 is summarized below:
|  |  |  |  |  | Weighted- |
|  | Number of |  |  | Average Grant- |
|  | Shares |  |  | Date Fair Value |
Unvested balance at January 1, 2017 |  |  | 91,228 |  |  | $ | 39.82 |
Granted |  |  | 11,799 |  |  |  | 4.67 |
Vested |  |  | (62,405 | ) |  |  | 37.63 |
Forfeited |  |  | (22,142 | ) |  |  | 45.45 |
Unvested balance at December 31, 2017 |  |  | 18,480 |  |  | $ | 18.00 |
Weighted Average Assumptions | The fair value of stock options granted during the years ended December 31, 2017, 2016, and 2015, was estimated based on the following weighted average assumptions for:
|  | Year Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected volatility |  |  | 100 | % |  |  | 101 | % |  |  | 84 | %
Risk-free interest rate |  |  | 1.90 | % |  |  | 1.84 | % |  |  | 1.40 | %
Expected term |  | 5.6 years |  |  | 5.6 years |  |  | 5.6 years |
Stock-based Compensation Expense | The following table shows total stock-based compensation expense for stock options, RSUs and ESPP in the consolidated statements of comprehensive income (loss) (in thousands):
|  | Year Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Research and development |  | $ | 876 |  |  | $ | 2,805 |  |  | $ | 5,022 |
General and administrative |  |  | 6,425 |  |  |  | 4,221 |  |  |  | 4,705 |
Restructuring |  |  | — |  |  |  | 619 |  |  | — |
Total stock-based compensation expense |  | $ | 7,301 |  |  | $ | 7,645 |  |  | $ | 9,727 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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