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Collaborative, Licensing and Other Arrangements - Pfizer - Additional Information (Details) - Collaborative Arrangement [Member] - Pfizer Inc. [Member] - USD ($) |  | 12 Months Ended | 60 Months Ended
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Dec. 03, 2015 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Milestone received under the collaboration agreement |  |  |  | $ 4,200,000
Amount received from settlement of the Pfizer agreement | $ 3,800,000 |  |  |
Royalties earned from sale |  | $ 0 | $ 400,000 |

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