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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Tax Disclosure [Abstract] |
Schedule of Provision for Income Taxes (All Current) | The provision for income taxes (all current) consists of the following (in thousands):
|  | Year Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Federal |  | $ | 1,649 |  |  | $ | — |  |  | $ | — |
State |  |  | 13 |  |  |  | — |  |  |  | — |
Total |  | $ | 1,662 |  |  | $ | — |  |  | $ | — |
Reconciliation Between the Tax Provision Computed at the Federal Statutory Income Tax Rate and Actual Effective Income Tax Rate | Reconciliation between the tax provision computed at the federal statutory income tax rate of 34% and the Company’s actual effective income tax rate is as follows:
|  | Year Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Federal tax at statutory rate |  |  | 34 | % |  |  | 34 | % |  |  | 34 | %
Warrant valuation |  |  | — |  |  |  | 7 | % |  |  | 29 | %
Stock compensation and other permanent differences |  |  | 6 | % |  |  | — |  |  | (1) | %
Tax credits |  | (4) | % |  |  | 2 | % |  | (14) | %
Impact of 2017 Tax Act on change in deferred |  |  | 128 | % |  |  | — |  |  |  | — |
Section 382 limitations |  |  | 868 | % |  |  | — |  |  |  | — |
Valuation allowance |  | (1,022) | % |  | (43) | % |  | (48) | %
Total |  |  | 10 | % |  |  | 0 | % |  |  | 0 | %
Components of Net Deferred Tax Assets | The significant components of net deferred tax assets at December 31, 2017 and 2016 were as follows (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
Capitalized research and development expenses |  | $ | 26,367 |  |  | $ | 53,557 |
Net operating loss carryforwards |  |  | 4,701 |  |  |  | 123,672 |
Research and development and other credit carryforwards |  |  | 12,225 |  |  |  | 25,297 |
Stock compensation |  |  | 3,680 |  |  |  | 7,099 |
Deferred revenue |  |  | 3,928 |  |  |  | 6,577 |
Other |  |  | 883 |  |  |  | 1,724 |
Total deferred tax assets |  |  | 51,784 |  |  |  | 217,926 |
Valuation allowance |  |  | (51,784 | ) |  |  | (217,926 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |
Schedule of Unrecognized Tax Benefits | The following table summarizes the Company's activity related to its unrecognized tax benefits (in thousands):
|  | Year Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Balance at January 1 |  | $ | 8,625 |  |  | $ | 9,666 |  |  | $ | 5,503 |
Increase related to current year tax position |  |  | 581 |  |  |  | 592 |  |  |  | 2,687 |
(Decrease) increase related to prior year tax position |  |  | (3,705 | ) |  |  | (1,633 | ) |  |  | 1,476 |
Balance at December 31 |  | $ | 5,501 |  |  | $ | 8,625 |  |  | $ | 9,666 |

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