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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense | $ 178 | $ 297 | $ 348 | $ 906
Novartis Note [Member] |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense | 144 | 119 | 283 | 236
Servier Loan [Member] |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense |  | $ 178 |  | 355
Hercules Loan [Member] |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense |  |  |  | 311
Other [Member] |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense | 22 |  | 53 | $ 4
SVB Loan [Member] |  |  |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |  |  |
Interest expense | $ 12 |  | $ 12 |

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- Definition Amount of the cost of borrowed funds accounted for as interest expense for debt. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 20 -Section 50 -Paragraph 6 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109500613&loc=SL6036836-161870 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227 + Details
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