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Long-Term Debt and Other Financings - Novartis Note - Additional Information (Details) - USD ($) |  |  | 1 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 22, 2017 | Sep. 30, 2015 | May 31, 2005 | Dec. 31, 2018 | Dec. 31, 2017
Novartis Note [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date |  |  | Jun. 30, 2015 |  |
Research and development expenses funded through loan facility, maximum |  |  | 75.00% |  |
Maximum borrowing capacity under loan agreement |  |  | $ 50,000,000 |  |
Interest rate at period end |  |  |  | 4.87% |
Outstanding principal balance |  |  |  | $ 15,200,000 | $ 14,600,000
Novartis Note [Member] | Six-month LIBOR [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Basis spread on variable rate |  |  | 2.00% |  |
Secured Note Amendment [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date | Sep. 30, 2022 | Sep. 30, 2020 |  |  |
Reduction in outstanding principal amount |  | $ 7,300,000 |  |  |

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