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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017
Cash flows from operating activities: |  |
Net (loss) income | $ (13,343) | $ 14,596
Adjustments to reconcile net (loss) income to net cash (used in) provided by operating activities: |  |
Fair value of Rezolute common stock shares received as consideration for license agreement | (955) |
License fee recognized related to repayment of principal and accrued interest under the Servicer Loan |  | (14,346)
Stock-based compensation expense | 3,902 | 7,301
Common stock contribution to 401(k) | 20 | 506
Depreciation and amortization | 30 | 304
Amortization of debt issuance costs, debt discount and final payment on debt | 141 | 444
Loss on sublease |  | 800
Loss on extinguishment of debt |  | 650
Realized (gain) loss on foreign currency exchange | (20) | 1,635
Net gain on sale, disposal and impairment of equipment |  | (1,068)
Change in fair value of long-term equity securities | 563 |
Other |  | 61
Changes in assets and liabilities: |  |
Trade and other receivables | (1,029) | 169
Prepaid expenses and other assets | (102) | 106
Accounts payable and accrued liabilities | (1,161) | (9,746)
Unearned revenue recognized under units-of-revenue method | (231) | (363)
Income tax payable | (1,637) | 1,637
Other liabilities | 1,178 |
Net cash (used in) provided by operating activities | (12,644) | 2,686
Cash flows from investing activities: |  |
Proceeds from sale of equipment |  | 1,614
Purchase of property and equipment | (6) | (8)
Purchase of royalty rights in connection with Agenus purchase agreement | (15,000) |
Net cash (used in) provided by investing activities | (15,006) | 1,606
Cash flows from financing activities: |  |
Proceeds from issuance of convertible preferred stock, net of issuance costs | 16,269 | 20,019
Proceeds from issuance of common stock, net of issuance costs | 6,063 | 10,160
Proceeds from exercise of options | 583 | 1,550
Proceeds from issuance of long-term debt | 7,500 |
Debt issuance costs and loan fees | (217) |
Principal payments – debt |  | (16,380)
Payment of final fee related to loan extinguishment |  | (1,150)
Principal payments – capital lease | (13) | (51)
Taxes paid related to net share settlement of equity awards | (246) | (890)
Net cash provided by financing activities | 29,939 | 13,258
Effect of exchange rate changes on cash | 20 | 179
Net increase in cash and cash equivalents | 2,309 | 17,729
Cash and cash equivalents at the beginning of the period | 43,471 | 25,742
Cash and cash equivalents at the end of the period | 45,780 | 43,471
Supplemental Cash Flow Information: |  |
Cash paid for interest | 81 | 545
Cash paid for taxes | 1,637 |
Non-cash investing and financing activities: |  |
Exchange of principal and accrued interest under the Servier loan |  | 14,346
Equipment acquired through capital lease |  | 45
Interest added to principal balance on long-term debt | 621 | $ 487
Accrued cost related to issuance of preferred and common stock | 417 |
Prepaid financing cost related to issuance of common stock | 100 |
Issuance of common stock warrant under SVB loan | $ 139 |

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