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Quarterly Financial Information (unaudited) (Parenthetical) (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Jun. 30, 2018 | Sep. 30, 2017 | Jun. 30, 2017 | Dec. 31, 2018 | Dec. 31, 2017
Quarterly Financial Information [Line Items] |  |  |  |  |  |
Revenue recognized |  |  |  |  | $ 5,068 | $ 52,428
Rezolute [Member] | License Agreement and Common Stock Purchase Agreement [Member] |  |  |  |  |  |
Quarterly Financial Information [Line Items] |  |  |  |  |  |
Revenue recognized |  | $ 1,800 |  |  |  |
Janseen [Member] | License Agreement [Member] |  |  |  |  |  |
Quarterly Financial Information [Line Items] |  |  |  |  |  |
Revenue recognized | $ 800 |  |  |  |  |
Novartis International [Member] | License Agreement [Member] |  |  |  |  |  |
Quarterly Financial Information [Line Items] |  |  |  |  |  |
Revenue recognized |  |  | $ 35,400 |  |  |
Milestone received under the collaboration agreement |  |  |  | $ 10,000 |  | $ 10,000

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