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Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | $ 922 | $ 1,238
Hercules Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense |  | 311
SVB Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | 258 |
Servier Loan [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense |  | 431
Novartis Note [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | 627 | 490
Other [Member] |  |
Interest expense and amortization of debt issuance costs [Abstract] |  |
Interest expense | $ 37 | $ 6

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- Definition Amount of the cost of borrowed funds accounted for as interest expense for debt. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 20 -Section 50 -Paragraph 6 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109500613&loc=SL6036836-161870 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.8) -URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227 + Details
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