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Long-Term Debt - Silicon Valley Bank Loan Agreement - Additional Information (Details) - Loan and Security Agreement [Member] - Silicon Valley Bank [Member] - USD ($) |  |  | 3 Months Ended
--- | --- | --- | ---
Mar. 04, 2019 | May 07, 2018 | Mar. 31, 2019
Warrants for Common Stock [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Aggregate number of shares of common stock called by warrants | 4,845 | 6,332 |
Exercise price of per share | $ 14.71 | $ 23.69 |
Exercisable period of warrants | 10 years | 10 years |
Fair value of warrant | $ 100,000 | $ 100,000 |
Term Loan [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Maximum borrowing capacity under loan agreement |  | 20,000,000 |
Increase borrowing capacity under loan agreement |  | $ 40,000,000 |
Earlier effecitve date of term loan |  | Mar. 31, 2019 |
Effective date of term loan extended |  | Mar. 31, 2020 |
Gross cash proceeds received from milestone and licensing payments |  | $ 20,000,000 |
Basis spread on variable rate |  | 4.75% |
Variable rate basis |  | The interest-only period will be followed by equal monthly payments of principal and interest over 24 months. Each Term Loan Advance will mature at the earlier of (i) the 23 months following the applicable term loan amortization date for each such Term Loan Advance (ii) March 1, 2023, or (iii) 30 days prior to the earliest maturity of any portion of the Company’s loan with Novartis (the “Loan Maturity Date”). After repayment, no Term Loan Advance (or any portion thereof) may be reborrowed. |
Period of monthly payments of principal and interest |  | 24 months |
Repayment of term loan |  | $ 0 |
Loan borrowed |  | $ 0 |
Percentage of final payment fee of Loan |  | 8.50% |
Percentage of prepayment fee |  | 3.00% |
Additional interest rate of outstanding payments due |  | 4.00% |
Debt issuance costs |  | $ 200,000 |
Term Loan [Member] | Agenus [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Loan borrowed |  |  | $ 7,500,000
Discount against debt |  |  | 300,000
Non-cash interest expense resulting from amortization of discount and accretion of final payment |  |  | 100,000
Carrying value of debt |  |  | $ 7,400,000
Term Loan [Member] | First Anniversary [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Percentage of prepayment fee |  | 2.00% |
Term Loan [Member] | Second Anniversary [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Percentage of prepayment fee |  | 1.00% |
Term Loan [Member] | Prime Rate [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Basis spread on variable rate |  | 0.25% |
Novartis [Member] |  |  |
Debt Instrument [Line Items] |  |  |
Maturity date |  | Mar. 01, 2023 |
Days of interest, period |  | 30 days |
Earliest maturity of loan |  | 30 days |

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