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Long-Term Debt - Novartis Note - Additional Information (Details) - USD ($) |  |  | 1 Months Ended |  |
--- | --- | --- | --- | --- | ---
Sep. 22, 2017 | Sep. 30, 2015 | May 31, 2005 | Mar. 31, 2019 | Dec. 31, 2018
Novartis Note [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date |  |  | Jun. 30, 2015 |  |
Research and development expenses funded through loan facility, maximum |  |  | 75.00% |  |
Maximum borrowing capacity under loan agreement |  |  | $ 50,000,000 |  |
Interest rate at period end |  |  |  | 4.90% |
Long-term Debt, Gross |  |  |  | $ 15,200,000 | $ 15,200,000
Novartis Note [Member] | Six-month LIBOR [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Basis spread on variable rate |  |  | 2.00% |  |
Secured Note Amendment [Member] |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Maturity date | Sep. 30, 2022 | Sep. 30, 2020 |  |  |
Reduction in outstanding principal amount |  | $ 7,300,000 |  |  |

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- Definition Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (b)(1) -URI http://asc.fasb.org/extlink&oid=109500613&loc=SL6031897-161870 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(16)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 + Details
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