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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (unaudited) - USD ($) shares in Thousands, $ in Thousands | Total | Convertible Preferred Stock [Member] | Common Stock [Member] | Additional Paid-In Capital [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2017 | $ 5,786 |  |  | $ 62 | $ 1,184,783 | $ (1,179,059)
Balance (in shares) at Dec. 31, 2017 |  |  | 5 | 8,249 |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Exercise of stock options | 14 |  |  |  | 14 |
Issuance of common stock related to 401(k) contribution and ESPP | 20 |  |  |  | 20 |
Issuance of common stock related to 401(k) contribution and ESPP (in shares) |  |  |  | 1 |  |
Vesting of restricted stock units (in shares) |  |  |  | 14 |  |
Stock-based compensation expense | 1,416 |  |  |  | 1,416 |
Issuance of common stock | 2,207 |  |  |  | 2,207 |
Issuance of common stock (in shares) |  |  |  | 68 |  |
Net income (loss) and comprehensive income (loss) | (3,806) |  |  |  |  | (3,806)
Balance at Mar. 31, 2018 | 5,637 |  |  | $ 62 | 1,188,440 | (1,182,865)
Balance (in shares) at Mar. 31, 2018 |  |  | 5 | 8,332 |  |
Balance at Dec. 31, 2018 | 18,785 | [1] |  | $ 65 | 1,211,122 | (1,192,402)
Balance (in shares) at Dec. 31, 2018 |  |  | 6 | 8,691 |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Exercise of stock options | 115 |  |  |  | 115 |
Exercise of stock options (in shares) |  |  |  | 24 |  |
Issuance of common stock related to 401(k) contribution and ESPP | 102 |  |  |  | 102 |
Issuance of common stock related to 401(k) contribution and ESPP (in shares) |  |  |  | 7 |  |
Vesting of restricted stock units (in shares) |  |  |  | 2 |  |
Stock-based compensation expense | 1,728 |  |  |  | 1,728 |
Issuance of warrants | 66 |  |  |  | 66 |
Net income (loss) and comprehensive income (loss) | 3,233 |  |  |  |  | 3,233
Balance at Mar. 31, 2019 | $ 24,029 |  |  | $ 65 | $ 1,213,133 | $ (1,189,169)
Balance (in shares) at Mar. 31, 2019 |  |  | 6 | 8,724 |  |
[1] | The condensed consolidated balance sheet as of December 31, 2018 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2018.

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