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Long-Term Debt and Other Financings - Novartis Note (Details) - USD ($) $ in Thousands | 1 Months Ended |  |  |
--- | --- | --- | --- | ---
May 31, 2005 | Dec. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2015
Long-term debt |  |  |  |
Debt amount |  | $ 32,277 |  |
Novartis Note |  |  |  |
Long-term debt |  |  |  |
Research and development expenses funded through loan facility, maximum (as a percent) | 75.00% |  |  |
Maximum borrowing capacity under loan agreement | $ 50,000 |  |  |
Interest rate at period end (as a percent) |  | 3.91% |  |
Amount by which note will be reduced upon achievement of specified milestones |  |  |  | $ 7,300
Debt amount |  | $ 15,900 | $ 15,200 |
Novartis Note | Six-month LIBOR [Member] |  |  |  |
Long-term debt |  |  |  |
Basis spread on variable rate | 2.00% |  |  |

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- Definition Amount, after unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 470 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (b)(3) -URI http://asc.fasb.org/extlink&oid=109500613&loc=SL6031897-161870 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(16)) -URI http://asc.fasb.org/extlink&oid=119400593&loc=d3e572229-122910 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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