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Stock-based Compensation | 6 Months Ended
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Jun. 30, 2021
Stock-based Compensation |
Compensation and Other Benefit Plans | 11. Stock-based Compensation The Company may grant qualified and non-qualified stock options, common stock and other stock-based awards under various plans to directors, officers, employees and other individuals. Stock options are granted at exercise prices of not less than the fair market value of the Company’s common stock on the date of grant. Additionally, the Company has an Employee Stock Purchase Plan (“ESPP”) that allows employees to purchase Company shares at a purchase price equal to 85% of the lower of the fair market value of the Company’s common stock on the first trading day of the offering period or on the last day of the offering period. Stock Options Stock options generally vest monthly over three years for employees and one year for directors. Stock options held by employees who qualify for retirement age (defined as employees that are a minimum of 55 years of age and the sum of their age plus years of full-time employment with the Company exceeds 70 years) vest on the earlier of scheduled vest date or the date of retirement. The fair value of the stock options granted during the three and six months ended June 30, 2021 and 2020, was estimated based on the following weighted average assumptions: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended June 30, |  | ​ | Six Months Ended June 30, |
​ |  | 2021 |  | 2020 |  |  | 2021 |  | 2020 |
Dividend yield |  | 0 | % | 0 | % |  | 0 | % | 0 | %
Expected volatility |  | 76 | % | 100 | % |  | 94 | % | 100 | %
Risk-free interest rate |  | 1.06 | % | 0.40 | % |  | 0.77 | % | 0.77 | %
Expected term |  | 6.00 years | ​ | 5.93 years | ​ |  | 5.68 years | ​ | 5.66 years | ​
​ Stock option activity for the six months ended June 30, 2021, was as follows: ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted |  | Weighted |  | ​
​ | ​ | ​ | ​ | Average | ​ | Average | ​ | Aggregate
​ | ​ | ​ | ​ | Exercise | ​ | Contractual | ​ | Intrinsic
​ | ​ | Number of | ​ | Price | ​ | Term | ​ | Value
​ | ​ | shares | ​ | Per Share | ​ | (in years) | ​ | (in thousands)
Outstanding at January 1, 2021 | ​ | ​ | 1,827,906 | ​ | $ | 20.66 |  | ​ | 6.31 |  | $ | 51,401
Granted |  | ​ | 176,429 | ​ |  | 37.62 |  | ​ |  |  | ​ |
Exercised |  | ​ | (73,575) | ​ |  | 13.35 |  | ​ |  |  | ​ |
Forfeited, expired or cancelled | ​ | ​ | (57,115) | ​ |  | 71.26 |  | ​ |  |  | ​ |
Outstanding at June 30, 2021 | ​ | ​ | 1,873,645 | ​ | $ | 21.00 |  | ​ | 6.19 | ​ | $ | 33,125
Exercisable at June 30, 2021 | ​ | ​ | 1,535,686 | ​ | $ | 19.37 |  | ​ | 5.58 | ​ | $ | 30,459
​ The aggregate intrinsic value of stock options exercised during the six months ended June 30, 2021 and 2020 was $1.5 million and $40,000, respectively. The weighted-average grant-date fair value per share of the options granted during the six months ended June 30, 2021 and 2020 was $27.89 and $16.22, respectively. As of June 30, 2021, $4.3 million of total unrecognized compensation expense related to stock options is expected to be recognized over a weighted average period of 1.73 years. Stock-based Compensation Expense The following table shows total stock-based compensation expense for stock options and ESPP in the condensed consolidated statements of operations and comprehensive loss (in thousands): ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Three Months Ended June 30, | ​ | Six Months Ended June 30,
​ |  | 2021 |  | 2020 |  | 2021 |  | 2020
Research and development | ​ | $ | — | ​ | $ | — | ​ | $ | — | ​ | $ | —
General and administrative | ​ |  | 768 | ​ |  | 773 | ​ |  | 3,666 | ​ |  | 2,561
Total stock-based compensation expense | ​ | $ | 768 | ​ | $ | 773 | ​ | $ | 3,666 | ​ | $ | 2,561
​

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