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Royalty and Commercial Payment Purchase Agreements - Summary (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | --- | ---
Agreements |  |  |
Short-term royalty and commercial payment receivables | $ 2,366 | $ 0 |
Long-term royalty and commercial payment receivables | $ 63,683 | $ 69,075 | $ 34,575

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Long-term royalty and commercial rights receivables, non current. + References No definition available. + Details
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Namespace Prefix: | xoma_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

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- Definition Royalty and commercial rights receivables, due within one year or the normal operating cycle, if longer. + References No definition available. + Details
Name: | xoma_RightsReceivableCurrent
Namespace Prefix: | xoma_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant