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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands |  | 3 Months Ended | 12 Months Ended | 111 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2014 | Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | Dec. 31, 2021 | Mar. 31, 2023 | Oct. 31, 2019 | Mar. 31, 2017 | Feb. 28, 2017
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net tax benefit |  | $ 24 | $ 12 | $ (2) | $ 15 | $ 0 |  |  |
Federal and state deferred tax benefits |  |  |  | 0 | 0 |  |  |  |
Valuation allowance |  |  |  | 77,288 | 50,931 |  |  |  |
Unrecognized tax benefits |  |  |  | 0 | 0 |  |  |  |
Interest and penalties |  |  |  | $ 0 | $ 0 |  |  |  |
Statutory rate |  | 21.00% | 21.00% | 21.00% | 21.00% |  |  |  |
Internal Revenue Service |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Period of cumulative change in ownership |  |  |  | 3 years |  |  |  |  |
Operating loss carryforwards, utilization after ownership change |  |  |  |  |  |  |  | $ 10,800 |
Operating loss carryforwards, utilization after five years after ownership change |  |  |  |  |  |  |  | 1,600 |
Operating loss carryforwards, utilization after 15 years thereafter after ownership change |  |  |  |  |  |  |  | 180 |
Remaining pre ownership change in operating loss carryforwards written off due to expiration |  |  |  |  |  |  |  | $ 1,600 |
Internal Revenue Service | Minimum |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Cumulative change in ownership percentage |  |  |  | 50.00% |  |  |  |  |
Research and Development |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net tax benefit | $ 0 |  |  |  |  |  |  |  |
Massachusetts | Research and Development |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Tax credit carryforwards |  |  |  | $ 3,556 |  |  |  |  |
Federal |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net operating loss carryforwards expire through 2037 |  |  |  | $ 22,399 |  |  |  |  |
Operating loss carryforwards expiration year |  |  |  | 2037 |  |  |  |  |
Net operating loss carryforwards without expiration |  |  |  | $ 151,708 |  |  |  |  |
Tax credit carryforwards expiration year |  |  |  | 2042 |  |  |  |  |
Federal | Internal Revenue Service |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net operating loss carryforwards |  |  |  |  |  |  | $ 46,123 |  | $ 12,400
Federal | Research and Development |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Tax credit carryforwards |  |  |  | $ 8,177 |  |  |  |  |
Federal | Massachusetts |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net operating loss carryforwards |  |  |  | $ 174,107 |  |  |  |  |
State |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Operating loss carryforwards expiration year |  |  |  | 2042 |  |  |  |  |
State | Massachusetts |  |  |  |  |  |  |  |  |
Income Taxes Disclosure [Line Items] |  |  |  |  |  |  |  |  |
Net operating loss carryforwards |  |  |  | $ 141,318 |  |  |  |  |
Tax credit carryforwards expiration year |  |  |  | 2037 |  |  |  |  |

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