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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended 111 Months Ended
Dec. 31, 2014
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Dec. 31, 2021
Mar. 31, 2023
Oct. 31, 2019
Mar. 31, 2017
Feb. 28, 2017
Income Taxes Disclosure [Line Items]                  
Net tax benefit   $ 24 $ 12 $ (2) $ 15 $ 0      
Federal and state deferred tax benefits       0 0        
Valuation allowance       77,288 50,931        
Unrecognized tax benefits       0 0        
Interest and penalties       $ 0 $ 0        
Statutory rate   21.00% 21.00% 21.00% 21.00%        
Internal Revenue Service                  
Income Taxes Disclosure [Line Items]                  
Period of cumulative change in ownership       3 years          
Operating loss carryforwards, utilization after ownership change               $ 10,800  
Operating loss carryforwards, utilization after five years after ownership change               1,600  
Operating loss carryforwards, utilization after 15 years thereafter after ownership change               180  
Remaining pre ownership change in operating loss carryforwards written off due to expiration               $ 1,600  
Internal Revenue Service | Minimum                  
Income Taxes Disclosure [Line Items]                  
Cumulative change in ownership percentage       50.00%          
Research and Development                  
Income Taxes Disclosure [Line Items]                  
Net tax benefit $ 0                
Massachusetts | Research and Development                  
Income Taxes Disclosure [Line Items]                  
Tax credit carryforwards       $ 3,556          
Federal                  
Income Taxes Disclosure [Line Items]                  
Net operating loss carryforwards expire through 2037       $ 22,399          
Operating loss carryforwards expiration year       2037          
Net operating loss carryforwards without expiration       $ 151,708          
Tax credit carryforwards expiration year       2042          
Federal | Internal Revenue Service                  
Income Taxes Disclosure [Line Items]                  
Net operating loss carryforwards             $ 46,123   $ 12,400
Federal | Research and Development                  
Income Taxes Disclosure [Line Items]                  
Tax credit carryforwards       $ 8,177          
Federal | Massachusetts                  
Income Taxes Disclosure [Line Items]                  
Net operating loss carryforwards       $ 174,107          
State                  
Income Taxes Disclosure [Line Items]                  
Operating loss carryforwards expiration year       2042          
State | Massachusetts                  
Income Taxes Disclosure [Line Items]                  
Net operating loss carryforwards       $ 141,318          
Tax credit carryforwards expiration year       2037