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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:        
Net loss $ (19,543) $ (23,386) $ (81,580) $ (84,686)
Adjustments to reconcile net loss to net cash used in operating activities:        
Stock-based compensation 3,431 5,266 19,831 21,750
Depreciation expense 1,000 726 2,766 2,775
Non-cash lease expense 630 593 2,370 1,066
Non-cash interest expense     396 347
Loss on disposal of assets     0 16
Non-cash interest (income) expense (112) 266    
Changes in operating assets and liabilities:        
Prepaid expenses and other current assets 2,051 1,385 681 (173)
Accounts payable (697) (429) (677) (2,292)
Deferred revenue     0 (14,068)
Lease liabilities (479) (412) (1,816) (396)
Accrued expenses (413) (1,352) (208) (398)
Net cash used in operating activities (14,132) (17,343) (58,237) (76,059)
Cash flows from investing activities:        
Sale of property and equipment 7 0 17 0
Purchase of property and equipment (100) (12) 0 (2,914)
Purchase of marketable securities (1,978) (20,786) (54,222) (92,445)
Redemption of marketable securities 7,570 8,136 85,338 29,233
Net cash provided by (used in) investing activities 5,499 (12,662) 31,133 (66,126)
Cash flows from financing activities:        
Proceeds from issuance of common stock, net 1 61 60 1,298
Proceeds from Employee Stock Purchase Plan 31 139 196 60
Repayment of Term Loan (2,500) 0 (833) 0
Net cash (used in) provided by financing activities (2,468) 200 (577) 1,358
Net decrease in cash, cash equivalents and restricted cash (11,101) (29,805) (27,681) (140,827)
Cash, cash equivalents, and restricted cash at beginning of period 53,653 81,334 81,334 222,161
Cash, cash equivalents, and restricted cash at end of period $ 42,552 $ 51,529 53,653 81,334
Supplemental disclosures:        
Cash paid for interest     $ 914 $ 703