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Accrued Expenses (Details) - Schedule of accrued expenses - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2021 | Dec. 31, 2020
Schedule of accrued expenses [Abstract] |  |
Consulting fees | $ 718,958 | $ 1,718,559
Professional fees | 420,935 | 1,261,751
Employee and director compensation | 363,878 | 878,292
Research and development fees | 70,000 | 17,817
Interest | 113,254 | 184,576
Settlement of Alpha Capital Note | 47,169 |
Travel expenses |  | 4,600
Other | 174,993 | 45,321
Total | $ 1,909,187 | $ 4,110,916

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- Definition The amount of accrued research and development fees. + References No definition available. + Details
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Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Accrued interest. + References No definition available. + Details
Name: | atnf_AccruedInterest
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. + References No definition available. + Details
Name: | atnf_AccruedLiabilities
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- References No definition available. + Details
Name: | atnf_ConsultingFees
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Amount of expenses incurred but not yet paid classified as other. + References No definition available. + Details
Name: | atnf_OtherAccruedLiabilities
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

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- References No definition available. + Details
Name: | atnf_ProfessionalFeesExpenses
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- References No definition available. + Details
Name: | atnf_ScheduleOfAccruedExpensesAbstract
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- Definition Travel expenses. + References No definition available. + Details
Name: | atnf_TravelAndEntertainmentExpenses
Namespace Prefix: | atnf_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Amount of expense for employee benefit and equity-based compensation. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

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- Definition Amounts payable for money transfers, money orders, and consumer payment service arrangements. Settlement liabilities include amounts payable to intermediaries for global payment transfers. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
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Period Type: | instant