<SEC-DOCUMENT>0001213900-21-038848-index.html : 20210727
<SEC-HEADER>0001213900-21-038848.hdr.sgml : 20210727
<ACCEPTANCE-DATETIME>20210727135627
ACCESSION NUMBER:		0001213900-21-038848
CONFORMED SUBMISSION TYPE:	424B4
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20210727
DATE AS OF CHANGE:		20210727

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			180 Life Sciences Corp.
		CENTRAL INDEX KEY:			0001690080
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				813832378
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B4
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-258045
		FILM NUMBER:		211117390

	BUSINESS ADDRESS:	
		STREET 1:		830 MENLO AVENUE, SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025
		BUSINESS PHONE:		650-507-0669

	MAIL ADDRESS:	
		STREET 1:		830 MENLO AVENUE, SUITE 100
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	KBL MERGER CORP. IV
		DATE OF NAME CHANGE:	20161115
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B4
<SEQUENCE>1
<FILENAME>ea144713-424b4_180lifesci.htm
<DESCRIPTION>PROSPECTUS SUPPLEMENT
<TEXT>
Document 1 - file: ea144713-424b4_180lifesci.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>img_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: img_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>img_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: img_002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>img_003.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: img_003.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>img_004.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: img_004.jpg

</DOCUMENT>
</SEC-DOCUMENT>