    <SEC-DOCUMENT>0001213900-21-047306-index.html : 20210910
    <SEC-HEADER>0001213900-21-047306.hdr.sgml : 20210910
    <ACCEPTANCE-DATETIME>20210910080135
    ACCESSION NUMBER:		0001213900-21-047306
    CONFORMED SUBMISSION TYPE:	424B4
    PUBLIC DOCUMENT COUNT:		5
    FILED AS OF DATE:		20210910
    DATE AS OF CHANGE:		20210910

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			180 Life Sciences Corp.
    		CENTRAL INDEX KEY:			0001690080
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				813832378
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B4
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-259209
    		FILM NUMBER:		211245887

    	BUSINESS ADDRESS:
    		STREET 1:		830 MENLO AVENUE, SUITE 100
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025
    		BUSINESS PHONE:		650-507-0669

    	MAIL ADDRESS:
    		STREET 1:		830 MENLO AVENUE, SUITE 100
    		CITY:			MENLO PARK
    		STATE:			CA
    		ZIP:			94025

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	KBL MERGER CORP. IV
    		DATE OF NAME CHANGE:	20161115
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B4
    <SEQUENCE>1
    <FILENAME>ea147025-424b4_180lifesci.htm
    <DESCRIPTION>PROSPECTUS
    <TEXT>
    Document 1 - file: ea147025-424b4_180lifesci.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>image_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: image_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>image_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: image_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>image_003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: image_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>image_004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: image_004.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>