<SEC-DOCUMENT>0001213900-25-075971-index.html : 20250814
<SEC-HEADER>0001213900-25-075971.hdr.sgml : 20250814
<ACCEPTANCE-DATETIME>20250813212901
ACCESSION NUMBER:		0001213900-25-075971
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250814
DATE AS OF CHANGE:		20250813

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			180 Life Sciences Corp.
		CENTRAL INDEX KEY:			0001690080
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				813832378
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-288194
		FILM NUMBER:		251213858

	BUSINESS ADDRESS:	
		STREET 1:		2875 SOUTH OCEAN
		STREET 2:		SUITE 200
		CITY:			PALM BEACH
		STATE:			FL
		ZIP:			33480
		BUSINESS PHONE:		650-507-0669

	MAIL ADDRESS:	
		STREET 1:		2875 SOUTH OCEAN
		STREET 2:		SUITE 200
		CITY:			PALM BEACH
		STATE:			FL
		ZIP:			33480

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	KBL MERGER CORP. IV
		DATE OF NAME CHANGE:	20161115
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>ea0252596-424b5_180life.htm
<DESCRIPTION>PROSPECTUS SUPPLEMENT
<TEXT>
Document 1 - file: ea0252596-424b5_180life.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: image_001.jpg

</DOCUMENT>
</SEC-DOCUMENT>