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Stockholder's Equity - Stock-based Compensation Expense Allocation (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Allocated stock-based compensation expense $ 1,998 $ 1,006
General and administrative    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Allocated stock-based compensation expense 1,744 677
Research and development    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Allocated stock-based compensation expense $ 254 $ 329