<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:4ac935c8-acd7-4078-a010-d8166688f707,g:62b990ab-d451-4f6d-92f0-709386d601f0-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.evolus.com/role/BalanceSheets" xlink:type="simple" xlink:href="eols-20211231.xsd#BalanceSheets"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/BalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_81ed1fba-9dc1-4c4d-ae18-e68af382231b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_AssetsCurrent_81ed1fba-9dc1-4c4d-ae18-e68af382231b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_cee96eea-8605-4408-afe6-85781801dbdf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_cee96eea-8605-4408-afe6-85781801dbdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_8ab3f685-e93a-41c0-ae3e-8811ad7b0f79" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_8ab3f685-e93a-41c0-ae3e-8811ad7b0f79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6ce90b9e-68e3-4290-95b9-b75110f96174" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_6ce90b9e-68e3-4290-95b9-b75110f96174" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_42376543-3147-4702-bb31-239dc9b16eff" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_Goodwill_42376543-3147-4702-bb31-239dc9b16eff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_a076766d-4585-444a-9923-88970e64ae6a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_6abf08e1-36f6-44d9-9c19-84577fe9054b" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_a076766d-4585-444a-9923-88970e64ae6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_4c90df39-ebf8-4acc-a7ee-85cdae1c3070" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9f396420-acf7-496b-9311-c6a2af894877" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4c90df39-ebf8-4acc-a7ee-85cdae1c3070" xlink:to="loc_us-gaap_StockholdersEquity_9f396420-acf7-496b-9311-c6a2af894877" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_ac83cb4a-8f58-4099-b186-ee985cfc2144" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4c90df39-ebf8-4acc-a7ee-85cdae1c3070" xlink:to="loc_us-gaap_CommitmentsAndContingencies_ac83cb4a-8f58-4099-b186-ee985cfc2144" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9e941b89-1ebf-44ec-a7fb-b653e7417964" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_4c90df39-ebf8-4acc-a7ee-85cdae1c3070" xlink:to="loc_us-gaap_Liabilities_9e941b89-1ebf-44ec-a7fb-b653e7417964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_0ccc03ed-37f5-4c44-bc3a-4e1c6af81c97" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_0ccc03ed-37f5-4c44-bc3a-4e1c6af81c97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_188c8521-1f93-444b-8a45-4d6daa91da54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_188c8521-1f93-444b-8a45-4d6daa91da54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_1293e13d-815d-4e20-a31f-a79e13ff7956" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_InventoryNet_1293e13d-815d-4e20-a31f-a79e13ff7956" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a96aa0cb-24f7-4b3a-8210-9020ca1421c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_a96aa0cb-24f7-4b3a-8210-9020ca1421c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_24644353-31f8-4c51-93af-1cb6e2097f9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_24644353-31f8-4c51-93af-1cb6e2097f9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_b5a10760-1058-4d77-a695-29e2403a12c2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_17ae4a01-4c50-4642-8a1d-89228e0cc2bf" xlink:to="loc_us-gaap_OtherAssetsCurrent_b5a10760-1058-4d77-a695-29e2403a12c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_9fbf560c-4c52-4c53-b993-7aa1645c4648" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_AccountsPayableCurrent_9fbf560c-4c52-4c53-b993-7aa1645c4648" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_73c8ff5e-5759-4f78-b6e9-63ec3e742afd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_73c8ff5e-5759-4f78-b6e9-63ec3e742afd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_e351b06e-aad4-4204-9830-6e2cd7217306" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_e351b06e-aad4-4204-9830-6e2cd7217306" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_ContingentRoyaltyObligationPayabletoRelatedPartyCurrent_5aecfb6d-5d13-4928-922b-f17ab08fe6ee" xlink:href="eols-20211231.xsd#eols_ContingentRoyaltyObligationPayabletoRelatedPartyCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_eols_ContingentRoyaltyObligationPayabletoRelatedPartyCurrent_5aecfb6d-5d13-4928-922b-f17ab08fe6ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtCurrent_f7f236ba-8b18-42cc-8fd4-066c05d11608" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuredDebtCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_SecuredDebtCurrent_f7f236ba-8b18-42cc-8fd4-066c05d11608" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableRelatedPartiesClassifiedCurrent_74ce12bd-baa7-4c73-a5ad-6a83574fde8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NotesPayableRelatedPartiesClassifiedCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_NotesPayableRelatedPartiesClassifiedCurrent_74ce12bd-baa7-4c73-a5ad-6a83574fde8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveCurrent_92f107bb-f366-46e6-9525-431ab06f6712" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationReserveCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_0b93cc00-900c-4bff-848c-0c9ac2743f4d" xlink:to="loc_us-gaap_LitigationReserveCurrent_92f107bb-f366-46e6-9525-431ab06f6712" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_572e4a4b-7665-411f-ac1e-6cc9fcdc4708" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_eb954196-7a64-4cf3-aaf5-7c4f8da7fa89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_572e4a4b-7665-411f-ac1e-6cc9fcdc4708" xlink:to="loc_us-gaap_PreferredStockValue_eb954196-7a64-4cf3-aaf5-7c4f8da7fa89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_9528de88-3e66-42c6-a6f5-32b8b9ad8086" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_572e4a4b-7665-411f-ac1e-6cc9fcdc4708" xlink:to="loc_us-gaap_CommonStockValue_9528de88-3e66-42c6-a6f5-32b8b9ad8086" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_459cf002-9186-4c43-aa96-c1f0bcaf202f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_572e4a4b-7665-411f-ac1e-6cc9fcdc4708" xlink:to="loc_us-gaap_AdditionalPaidInCapital_459cf002-9186-4c43-aa96-c1f0bcaf202f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_725fb46a-a53b-42c8-8643-d7f78816a11f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_572e4a4b-7665-411f-ac1e-6cc9fcdc4708" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_725fb46a-a53b-42c8-8643-d7f78816a11f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_9cd67b26-f9bb-4981-b6a5-b9e93a697b9d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_9cd67b26-f9bb-4981-b6a5-b9e93a697b9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_e652d1d1-bf61-4de3-afe3-b9b66eca2679" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_LiabilitiesCurrent_e652d1d1-bf61-4de3-afe3-b9b66eca2679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationReserveNoncurrent_31bf9859-5377-412f-9b60-74fa0bbe4a8e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationReserveNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_LitigationReserveNoncurrent_31bf9859-5377-412f-9b60-74fa0bbe4a8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractualObligation_2667465b-f9ad-4d69-9346-d0a78bcc48b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractualObligation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_ContractualObligation_2667465b-f9ad-4d69-9346-d0a78bcc48b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_577df66d-d5a8-42b0-82c6-a122dcb99f95" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_577df66d-d5a8-42b0-82c6-a122dcb99f95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_4b110e3f-8959-4945-85c3-99b4890faf5e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_ConvertibleLongTermNotesPayable_4b110e3f-8959-4945-85c3-99b4890faf5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredLongTermDebt_22ed33fd-7355-49c1-8638-ecd4b8933178" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SecuredLongTermDebt"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_d80d9a93-c68b-4381-9fa3-ca0351449d69" xlink:to="loc_us-gaap_SecuredLongTermDebt_22ed33fd-7355-49c1-8638-ecd4b8933178" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/StatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="eols-20211231.xsd#StatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/StatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_6b5b8f02-a7cf-4036-bc9a-7e31537769fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4d9b4e18-666c-4f24-a058-b4834c99c145" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_6b5b8f02-a7cf-4036-bc9a-7e31537769fa" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4d9b4e18-666c-4f24-a058-b4834c99c145" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_2d292ffb-9dd7-4b3d-8eb7-878bc7a30989" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_6b5b8f02-a7cf-4036-bc9a-7e31537769fa" xlink:to="loc_us-gaap_CostsAndExpenses_2d292ffb-9dd7-4b3d-8eb7-878bc7a30989" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_045728df-ffba-4141-be8c-1f0b1cc6ea7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1757a4c2-8467-46de-b285-cecee882a151" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_045728df-ffba-4141-be8c-1f0b1cc6ea7c" xlink:to="loc_us-gaap_NetIncomeLoss_1757a4c2-8467-46de-b285-cecee882a151" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_2caf3e08-51a2-41ff-904c-3afaa99e1bfc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_045728df-ffba-4141-be8c-1f0b1cc6ea7c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_2caf3e08-51a2-41ff-904c-3afaa99e1bfc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_9fcac91b-b966-4d4f-a67c-47f264d02239" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_9fcac91b-b966-4d4f-a67c-47f264d02239" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_d47b5dfe-5b31-4339-b224-b9d078ffac67" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_d47b5dfe-5b31-4339-b224-b9d078ffac67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_f398bd9d-43ce-4486-9859-77f11502832b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_f398bd9d-43ce-4486-9859-77f11502832b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_58068da3-aa4c-4a5a-89ac-24db1fb46188" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationSettlementAmountAwardedToOtherParty"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_58068da3-aa4c-4a5a-89ac-24db1fb46188" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LitigationSettlementExpense_4a5979a9-b3df-45c0-b1b6-42b2941ae203" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LitigationSettlementExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_LitigationSettlementExpense_4a5979a9-b3df-45c0-b1b6-42b2941ae203" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_ac7dc8fc-f5f1-479f-9cb5-a27ea0d097c1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringCharges"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_RestructuringCharges_ac7dc8fc-f5f1-479f-9cb5-a27ea0d097c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_ff21e8c0-3fed-4baa-8689-d29e5fcb257f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_ff21e8c0-3fed-4baa-8689-d29e5fcb257f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9df545f0-51e0-4f63-8d39-eddf96588154" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_c961cfc2-27f8-48e3-bf7b-91e8d8d11be9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9df545f0-51e0-4f63-8d39-eddf96588154" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_101b336b-b784-4f18-a2b8-d61b38e4ed5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cce4ed71-8579-4856-ac99-01efefe1b279" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_101b336b-b784-4f18-a2b8-d61b38e4ed5b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cce4ed71-8579-4856-ac99-01efefe1b279" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ab32d9b6-e69c-41d5-98ad-4909c7d5cb35" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_101b336b-b784-4f18-a2b8-d61b38e4ed5b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ab32d9b6-e69c-41d5-98ad-4909c7d5cb35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2c613559-cc4f-4ab3-be68-55a06706832a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ce62a730-911c-422b-80b6-c31303fc43bc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2c613559-cc4f-4ab3-be68-55a06706832a" xlink:to="loc_us-gaap_OperatingIncomeLoss_ce62a730-911c-422b-80b6-c31303fc43bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNet_dd175dba-b586-41bc-82fb-a1e9f6b18a50" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InvestmentIncomeNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2c613559-cc4f-4ab3-be68-55a06706832a" xlink:to="loc_us-gaap_InvestmentIncomeNet_dd175dba-b586-41bc-82fb-a1e9f6b18a50" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f08a94d0-c82e-4e7a-81cd-7e2cf795661b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2c613559-cc4f-4ab3-be68-55a06706832a" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f08a94d0-c82e-4e7a-81cd-7e2cf795661b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f9c8dae3-6d23-4026-90e1-2f24e9903630" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2c613559-cc4f-4ab3-be68-55a06706832a" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_f9c8dae3-6d23-4026-90e1-2f24e9903630" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/StatementsofCashFlows" xlink:type="simple" xlink:href="eols-20211231.xsd#StatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/StatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_262c749e-ef88-4a85-a689-0db460a9a292" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_86291aff-b307-4947-8d0e-11ac5488fb6f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_262c749e-ef88-4a85-a689-0db460a9a292" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_86291aff-b307-4947-8d0e-11ac5488fb6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForSoftware_07b4c92d-5f2d-4772-961d-04d104ca2f09" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForSoftware"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_262c749e-ef88-4a85-a689-0db460a9a292" xlink:to="loc_us-gaap_PaymentsForSoftware_07b4c92d-5f2d-4772-961d-04d104ca2f09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireInvestments_36b1ae31-3d3e-481c-8673-e080bc9572c6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_262c749e-ef88-4a85-a689-0db460a9a292" xlink:to="loc_us-gaap_PaymentsToAcquireInvestments_36b1ae31-3d3e-481c-8673-e080bc9572c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_c7c8e786-d0bf-4ed0-a1fb-b83f00330ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_262c749e-ef88-4a85-a689-0db460a9a292" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_c7c8e786-d0bf-4ed0-a1fb-b83f00330ce6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_68b81b9a-c104-4fc5-a53a-fc64d3304ded" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_68b81b9a-c104-4fc5-a53a-fc64d3304ded" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_950539db-8d70-4547-ac6c-90dd3b08ed35" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_950539db-8d70-4547-ac6c-90dd3b08ed35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_c8ae04e3-c1cf-4ef0-9b67-d50e2ddc3de0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_c8ae04e3-c1cf-4ef0-9b67-d50e2ddc3de0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_9fb61518-4f5f-4af9-8ae2-54757e20abbe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_9fb61518-4f5f-4af9-8ae2-54757e20abbe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaidInKindInterest_2af79d63-742e-40af-9419-9a2e5b0ae2a2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaidInKindInterest"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_PaidInKindInterest_2af79d63-742e-40af-9419-9a2e5b0ae2a2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_5cb998e9-e424-4339-90a2-d513549a4642" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_5cb998e9-e424-4339-90a2-d513549a4642" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_8a31d741-9e27-4417-ae20-26c180bc58e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_8a31d741-9e27-4417-ae20-26c180bc58e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e2fd0c24-1b79-49e7-af3a-f5e6c748f075" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_NetIncomeLoss_e2fd0c24-1b79-49e7-af3a-f5e6c748f075" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_IncreaseDecreaseInAccruedLitigationSettlement_e0d604f6-4825-4297-ab37-e0a0e6d3a036" xlink:href="eols-20211231.xsd#eols_IncreaseDecreaseInAccruedLitigationSettlement"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_eols_IncreaseDecreaseInAccruedLitigationSettlement_e0d604f6-4825-4297-ab37-e0a0e6d3a036" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_OperatingLeaseRightofUseAssetAmortization_ad3ebe0a-b741-4bc6-a841-fe6775f72c1a" xlink:href="eols-20211231.xsd#eols_OperatingLeaseRightofUseAssetAmortization"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_eols_OperatingLeaseRightofUseAssetAmortization_ad3ebe0a-b741-4bc6-a841-fe6775f72c1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_887a1802-e248-4d4f-b17f-6e08fe3c59fc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_887a1802-e248-4d4f-b17f-6e08fe3c59fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_75b22f4b-3b7f-400e-a476-1f374733721f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_75b22f4b-3b7f-400e-a476-1f374733721f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7bac96d9-79a6-42d3-bbef-07a312edd885" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_7bac96d9-79a6-42d3-bbef-07a312edd885" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_d7c81783-db71-4652-adff-a7825e5da796" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_d7c81783-db71-4652-adff-a7825e5da796" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_1c0a289c-7a1f-47f8-aa26-24841fe222fe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_1c0a289c-7a1f-47f8-aa26-24841fe222fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_efbc4641-d93a-4c19-92ee-7f8788151709" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_efbc4641-d93a-4c19-92ee-7f8788151709" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5e4d6216-d78f-4ef3-aa3a-194ee9dd4f88" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_5e4d6216-d78f-4ef3-aa3a-194ee9dd4f88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_IncreaseDecreaseInOperatingLeaseLiabilities_589d24fb-e608-4641-bae4-ac379c8bab74" xlink:href="eols-20211231.xsd#eols_IncreaseDecreaseInOperatingLeaseLiabilities"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_eols_IncreaseDecreaseInOperatingLeaseLiabilities_589d24fb-e608-4641-bae4-ac379c8bab74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_fbc5ef18-b5d7-43b2-80da-c0a90ac29de9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="19" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_us-gaap_ShareBasedCompensation_fbc5ef18-b5d7-43b2-80da-c0a90ac29de9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_AdjustmentsOfNonCashPortionOfAccruedSettlementExpenses_4fa7094a-f179-494c-95a4-9637cd34fa24" xlink:href="eols-20211231.xsd#eols_AdjustmentsOfNonCashPortionOfAccruedSettlementExpenses"/>
    <link:calculationArc order="20" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ab109fb2-496c-4c1d-841f-fa5acf4fc281" xlink:to="loc_eols_AdjustmentsOfNonCashPortionOfAccruedSettlementExpenses_4fa7094a-f179-494c-95a4-9637cd34fa24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ebb3c766-f4cf-42c8-b25e-1129cd3d4d71" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2776184c-4c5c-4e1f-b531-eee96f9996c0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ebb3c766-f4cf-42c8-b25e-1129cd3d4d71" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_2776184c-4c5c-4e1f-b531-eee96f9996c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_609d02a9-95c8-44fd-b2fb-5c109a3a1584" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ebb3c766-f4cf-42c8-b25e-1129cd3d4d71" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_609d02a9-95c8-44fd-b2fb-5c109a3a1584" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4f6ecd84-da98-4d85-bdd5-a18a3cf6ade5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ebb3c766-f4cf-42c8-b25e-1129cd3d4d71" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4f6ecd84-da98-4d85-bdd5-a18a3cf6ade5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_47caaa0d-b16d-4bfb-b0fc-903398932c03" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_47caaa0d-b16d-4bfb-b0fc-903398932c03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_3b7748fb-f4cc-47f6-86b7-08e23fc4dc2e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_RepaymentsOfDebt_3b7748fb-f4cc-47f6-86b7-08e23fc4dc2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromConvertibleDebt_af1a410b-c4ad-480f-9dd1-8f9561c841e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromConvertibleDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_ProceedsFromConvertibleDebt_af1a410b-c4ad-480f-9dd1-8f9561c841e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_7099f3b6-12cc-4248-bc9a-58cdcb0dca4c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_7099f3b6-12cc-4248-bc9a-58cdcb0dca4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_16bd73fa-8d68-42b6-b5a9-499e16c681bb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfOtherLongTermDebt_16bd73fa-8d68-42b6-b5a9-499e16c681bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_ProceedsFromPaymentsForIssuanceOfCommonStockInConnectionWithEquityIncentivePlan_da71dddf-b111-4c93-864d-a2021728d9b5" xlink:href="eols-20211231.xsd#eols_ProceedsFromPaymentsForIssuanceOfCommonStockInConnectionWithEquityIncentivePlan"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_eols_ProceedsFromPaymentsForIssuanceOfCommonStockInConnectionWithEquityIncentivePlan_da71dddf-b111-4c93-864d-a2021728d9b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_PaymentsOfContingentRoyaltyObligation_97c80f9d-cc55-4fd5-861d-119dc7f8c57d" xlink:href="eols-20211231.xsd#eols_PaymentsOfContingentRoyaltyObligation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_eols_PaymentsOfContingentRoyaltyObligation_97c80f9d-cc55-4fd5-861d-119dc7f8c57d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_3080bccc-61b2-4a90-bac3-174baf7a1609" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_3080bccc-61b2-4a90-bac3-174baf7a1609" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_d36cf269-87c3-49ce-abf3-3986cdd609ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_d36cf269-87c3-49ce-abf3-3986cdd609ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_490fb7fb-8f5f-4bf8-a85b-6a96038b70e8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d07b0bf8-8552-4132-b0ad-4b636ed98b11" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_490fb7fb-8f5f-4bf8-a85b-6a96038b70e8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/FairValueMeasurementsandShortTermInvestmentsShorttermInvestmentsAvailableforSaleDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#FairValueMeasurementsandShortTermInvestmentsShorttermInvestmentsAvailableforSaleDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/FairValueMeasurementsandShortTermInvestmentsShorttermInvestmentsAvailableforSaleDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_58043225-212e-47df-8baf-9293112176da" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4768b12e-1525-481b-aacc-b3b66df45992" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_58043225-212e-47df-8baf-9293112176da" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4768b12e-1525-481b-aacc-b3b66df45992" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_57a00cff-939b-4d15-9c53-a8a9f461d4c8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_58043225-212e-47df-8baf-9293112176da" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_57a00cff-939b-4d15-9c53-a8a9f461d4c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0aae45c8-6418-492e-872d-b87246d8ef3c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_58043225-212e-47df-8baf-9293112176da" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0aae45c8-6418-492e-872d-b87246d8ef3c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_eols_IntangibleAssetsGrossIncludingGoodwill_213f1062-3c2a-41b2-af37-c9a93158da40" xlink:href="eols-20211231.xsd#eols_IntangibleAssetsGrossIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ef5bd217-0d4f-40b5-9003-129630aab316" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_eols_IntangibleAssetsGrossIncludingGoodwill_213f1062-3c2a-41b2-af37-c9a93158da40" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ef5bd217-0d4f-40b5-9003-129630aab316" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_d85506a6-5e5c-4b30-85b0-b49fca2b57eb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_eols_IntangibleAssetsGrossIncludingGoodwill_213f1062-3c2a-41b2-af37-c9a93158da40" xlink:to="loc_us-gaap_Goodwill_d85506a6-5e5c-4b30-85b0-b49fca2b57eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_43eb0908-7059-438f-8fd4-2b30c96344b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_97a7f6e7-7294-491e-a6e7-08029bc016e1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_43eb0908-7059-438f-8fd4-2b30c96344b4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_97a7f6e7-7294-491e-a6e7-08029bc016e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019e5c44-db8a-426e-98af-da5ca5e8868a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_43eb0908-7059-438f-8fd4-2b30c96344b4" xlink:to="loc_us-gaap_Goodwill_019e5c44-db8a-426e-98af-da5ca5e8868a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_5fa19949-2dc3-46a8-a078-8baa74947d8a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4d16e157-7235-49e6-979b-56108e25965e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_5fa19949-2dc3-46a8-a078-8baa74947d8a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4d16e157-7235-49e6-979b-56108e25965e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d5868b57-89f9-4dae-90db-463a2efae608" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_5fa19949-2dc3-46a8-a078-8baa74947d8a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_d5868b57-89f9-4dae-90db-463a2efae608" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsEstimatedFutureAmortizationExpenseofIntangiblesDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#GoodwillandIntangibleAssetsEstimatedFutureAmortizationExpenseofIntangiblesDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/GoodwillandIntangibleAssetsEstimatedFutureAmortizationExpenseofIntangiblesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_7a76dba6-e29b-4936-8659-544bab0f4ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_7a76dba6-e29b-4936-8659-544bab0f4ffa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_b722b4a8-2551-402e-a5c1-3ff461dd6343" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_b722b4a8-2551-402e-a5c1-3ff461dd6343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_50d6fd3d-17a6-42e6-95cd-4c32f304d713" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_50d6fd3d-17a6-42e6-95cd-4c32f304d713" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_cceffc13-7cab-4863-94d9-bde3d6bfad69" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_cceffc13-7cab-4863-94d9-bde3d6bfad69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_af5229c0-1faf-49be-aea6-8055a81c31ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_af5229c0-1faf-49be-aea6-8055a81c31ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_b1c36113-182c-4fdf-a4b7-ecb686b3f9fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_188de180-5d0d-4320-a1bc-611977e01ea2" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_b1c36113-182c-4fdf-a4b7-ecb686b3f9fb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#AccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/AccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_d5ef832c-e27c-4895-9aae-6edb5aa8fa26" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_d5ef832c-e27c-4895-9aae-6edb5aa8fa26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_5f289bf3-3159-418d-8abd-cc0ba6a86326" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_5f289bf3-3159-418d-8abd-cc0ba6a86326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_77e7ed19-9a3d-4ea7-885d-a0124da220c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_77e7ed19-9a3d-4ea7-885d-a0124da220c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e94a2e34-d13b-4bc3-ad5d-3c637dec0df0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e94a2e34-d13b-4bc3-ad5d-3c637dec0df0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_8d0f2a64-e170-424b-bf66-a29528018a83" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_7a93a64d-ff0f-4483-8c08-52d7d85674a5" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_8d0f2a64-e170-424b-bf66-a29528018a83" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/TermLoansScheduleofLongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#TermLoansScheduleofLongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/TermLoansScheduleofLongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_99a528ff-057f-4d8e-80bb-21c1164ae693" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_60e64758-545a-4ba1-9c78-3c0cd41bf555" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_99a528ff-057f-4d8e-80bb-21c1164ae693" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_60e64758-545a-4ba1-9c78-3c0cd41bf555" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_bb22596e-6699-4d81-8f30-6fb93a465e54" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_99a528ff-057f-4d8e-80bb-21c1164ae693" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_bb22596e-6699-4d81-8f30-6fb93a465e54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_9d877758-31b3-41f0-bc89-ee9db13c796b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_9d877758-31b3-41f0-bc89-ee9db13c796b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_bfc42d78-f613-4eb6-8a93-17913ac660df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_bfc42d78-f613-4eb6-8a93-17913ac660df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_28b9aa1d-e9ec-412b-bb7e-2e55fb077f56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_28b9aa1d-e9ec-412b-bb7e-2e55fb077f56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f441c1c6-b1e9-4fad-a0ce-ef8e5e55ec57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f441c1c6-b1e9-4fad-a0ce-ef8e5e55ec57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_a8a6e4ef-5645-4922-a39b-29741a1e261d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_a8a6e4ef-5645-4922-a39b-29741a1e261d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_ff493563-c5ff-477a-a1e5-0652236c2061" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_1d3cac12-ed4c-4fb0-aac1-681176884fd8" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_ff493563-c5ff-477a-a1e5-0652236c2061" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/OperatingLeasesComponentsofLeaseExpenseandOtherQuantitativeInformationDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#OperatingLeasesComponentsofLeaseExpenseandOtherQuantitativeInformationDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/OperatingLeasesComponentsofLeaseExpenseandOtherQuantitativeInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_d31ab68f-3e4b-47ab-bd1d-f66dbe4c2e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_41e6daa5-4625-4d4a-9b59-52533ad4336e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_d31ab68f-3e4b-47ab-bd1d-f66dbe4c2e1e" xlink:to="loc_us-gaap_OperatingLeaseCost_41e6daa5-4625-4d4a-9b59-52533ad4336e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_9b1cea3d-8a07-4a8e-80dd-1b1913d09176" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_d31ab68f-3e4b-47ab-bd1d-f66dbe4c2e1e" xlink:to="loc_us-gaap_VariableLeaseCost_9b1cea3d-8a07-4a8e-80dd-1b1913d09176" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_65789bf9-371f-478d-bfe1-ce835b4f3a80" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_d31ab68f-3e4b-47ab-bd1d-f66dbe4c2e1e" xlink:to="loc_us-gaap_ShortTermLeaseCost_65789bf9-371f-478d-bfe1-ce835b4f3a80" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d7fe2039-63b6-46c8-ba85-7878ebbbd396" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_89993726-8095-4d92-8a37-b0dfa9611565" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d7fe2039-63b6-46c8-ba85-7878ebbbd396" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_89993726-8095-4d92-8a37-b0dfa9611565" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_aea60ba6-29d3-4295-8d0b-b3ddecb080b4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_d7fe2039-63b6-46c8-ba85-7878ebbbd396" xlink:to="loc_us-gaap_OperatingLeaseLiability_aea60ba6-29d3-4295-8d0b-b3ddecb080b4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="eols-20211231.xsd#OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/OperatingLeasesMaturityofOperatingLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_194eeb16-1e87-41ce-828b-3974c0a6aa8f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_080af557-5fbd-45ab-982d-f3dcfb1801ce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_194eeb16-1e87-41ce-828b-3974c0a6aa8f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_080af557-5fbd-45ab-982d-f3dcfb1801ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_089f2bb9-5796-41a3-955b-9b8949287233" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_194eeb16-1e87-41ce-828b-3974c0a6aa8f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_089f2bb9-5796-41a3-955b-9b8949287233" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_020a2ac2-8671-483b-b215-950e64faebd8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_194eeb16-1e87-41ce-828b-3974c0a6aa8f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_020a2ac2-8671-483b-b215-950e64faebd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_841c377e-9ebe-452c-b7cb-ff1e20540006" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_194eeb16-1e87-41ce-828b-3974c0a6aa8f" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_841c377e-9ebe-452c-b7cb-ff1e20540006" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/IncomeTaxesComponentsofCurrentandDeferredTaxExpenseDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#IncomeTaxesComponentsofCurrentandDeferredTaxExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/IncomeTaxesComponentsofCurrentandDeferredTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_e83b9ba8-032b-40a8-99d5-1e6ab465d423" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_55bddf00-069a-4e66-a4d5-8d86b08e4683" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_e83b9ba8-032b-40a8-99d5-1e6ab465d423" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_55bddf00-069a-4e66-a4d5-8d86b08e4683" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_dae8dfab-72a5-4e48-a9c9-fc516971a068" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_e83b9ba8-032b-40a8-99d5-1e6ab465d423" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_dae8dfab-72a5-4e48-a9c9-fc516971a068" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_65bd0f90-a6a4-4e8a-9301-9477e9bdd06c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_503e14cb-a43d-42bd-b1dd-944439421db3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_65bd0f90-a6a4-4e8a-9301-9477e9bdd06c" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_503e14cb-a43d-42bd-b1dd-944439421db3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_ff36cafe-3460-4b78-ad9f-1b453ecee3c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_65bd0f90-a6a4-4e8a-9301-9477e9bdd06c" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_ff36cafe-3460-4b78-ad9f-1b453ecee3c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_32f61dc9-a42c-457a-83d4-5e009074ba14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_1fe1634b-c584-4429-b600-58d359b1f50c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_32f61dc9-a42c-457a-83d4-5e009074ba14" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_1fe1634b-c584-4429-b600-58d359b1f50c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_e7c07f0f-48e8-492e-8a2f-e518b883eb31" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_32f61dc9-a42c-457a-83d4-5e009074ba14" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_e7c07f0f-48e8-492e-8a2f-e518b883eb31" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_f5153b8b-5ff0-4540-bcfb-582433c5ac6d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_f5153b8b-5ff0-4540-bcfb-582433c5ac6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_b154875d-8b13-43b0-9cb5-d34061c89218" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_b154875d-8b13-43b0-9cb5-d34061c89218" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseOther_a0ebe1d9-85a9-45fd-b42f-440593e1ad02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseOther_a0ebe1d9-85a9-45fd-b42f-440593e1ad02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_cdafb1cd-d915-4114-b0a9-8ecdc629f66e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_cdafb1cd-d915-4114-b0a9-8ecdc629f66e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_DeferredTaxAssetsOperatingLeaseLiabilities_b01a4598-22c0-4cdc-8eec-df1bce72e0e7" xlink:href="eols-20211231.xsd#eols_DeferredTaxAssetsOperatingLeaseLiabilities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_eols_DeferredTaxAssetsOperatingLeaseLiabilities_b01a4598-22c0-4cdc-8eec-df1bce72e0e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_4f5e5f53-5d8c-4062-94cf-862b43d41d8b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_4f5e5f53-5d8c-4062-94cf-862b43d41d8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_982e258f-c6f3-4e10-836c-2f5b6cba3af7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_982e258f-c6f3-4e10-836c-2f5b6cba3af7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsLegalSettlements_8a565fd9-f72a-4a5f-a244-52ed4705585f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsLegalSettlements"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_db16cb01-dd36-400c-b2af-b0ead73ba5d8" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsLegalSettlements_8a565fd9-f72a-4a5f-a244-52ed4705585f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilities_c1c03749-311a-45b0-9c25-0c747fb25678" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_0794de28-4e50-46bc-bdaa-4a32bdce5cce" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_c1c03749-311a-45b0-9c25-0c747fb25678" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_0794de28-4e50-46bc-bdaa-4a32bdce5cce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_bd91cb28-1d18-4942-949a-c9fa518a326b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxLiabilities_c1c03749-311a-45b0-9c25-0c747fb25678" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_bd91cb28-1d18-4942-949a-c9fa518a326b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_baac451b-be12-48f0-aca5-a79101719afc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_dfc73cfd-b416-4893-962b-51444bd42e34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_baac451b-be12-48f0-aca5-a79101719afc" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_dfc73cfd-b416-4893-962b-51444bd42e34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_439a6bf2-53a2-489f-b9e1-9284c1229211" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_baac451b-be12-48f0-aca5-a79101719afc" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_439a6bf2-53a2-489f-b9e1-9284c1229211" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_83831e21-b64e-4aa5-af8c-8b2827453407" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_baac451b-be12-48f0-aca5-a79101719afc" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_83831e21-b64e-4aa5-af8c-8b2827453407" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.evolus.com/role/IncomeTaxesReconciliationofEffectiveTaxDetails" xlink:type="simple" xlink:href="eols-20211231.xsd#IncomeTaxesReconciliationofEffectiveTaxDetails"/>
  <link:calculationLink xlink:role="http://www.evolus.com/role/IncomeTaxesReconciliationofEffectiveTaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_ed18df33-20c0-4218-b85e-11df88a7ac3a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_ed18df33-20c0-4218-b85e-11df88a7ac3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_6e4edfc9-60a7-4d51-a2bb-3c96f5297015" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_6e4edfc9-60a7-4d51-a2bb-3c96f5297015" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentRoyaltyObligation_f1023992-2ea8-4cd2-8d58-e0644812c3db" xlink:href="eols-20211231.xsd#eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentRoyaltyObligation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentRoyaltyObligation_f1023992-2ea8-4cd2-8d58-e0644812c3db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseMealsAndEntertainment_bf80d9ee-ffbf-4b48-8e33-c4f6f6fdb1ca" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseMealsAndEntertainment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseMealsAndEntertainment_bf80d9ee-ffbf-4b48-8e33-c4f6f6fdb1ca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_846f5a7b-c908-43a7-aaa5-0c2e4aeecf08" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_846f5a7b-c908-43a7-aaa5-0c2e4aeecf08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_80f9df3a-80b4-462a-905a-ed5fadcc8d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_80f9df3a-80b4-462a-905a-ed5fadcc8d3d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_e9422a77-0681-4344-b712-0677a95e1cec" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_e9422a77-0681-4344-b712-0677a95e1cec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_EffectiveIncomeTaxRateReconciliationPromissoryNoteDebtDiscount_be5a03bc-0912-469c-804c-1dcf7a3e7bf3" xlink:href="eols-20211231.xsd#eols_EffectiveIncomeTaxRateReconciliationPromissoryNoteDebtDiscount"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_eols_EffectiveIncomeTaxRateReconciliationPromissoryNoteDebtDiscount_be5a03bc-0912-469c-804c-1dcf7a3e7bf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingenciesOther_98cad55a-e3b9-4355-b3b4-7e53ecda5179" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxContingenciesOther"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingenciesOther_98cad55a-e3b9-4355-b3b4-7e53ecda5179" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_4ad5362e-6f54-49d4-89f2-fdb478d22f43" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_4ad5362e-6f54-49d4-89f2-fdb478d22f43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_eols_EffectiveIncomeTaxRateReconciliationOfficersCompensation_1e8d4ebe-e263-44ef-9a37-ee9d2b6b04bf" xlink:href="eols-20211231.xsd#eols_EffectiveIncomeTaxRateReconciliationOfficersCompensation"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_bb537d38-1162-458b-8cc6-bae02dfb1c99" xlink:to="loc_eols_EffectiveIncomeTaxRateReconciliationOfficersCompensation_1e8d4ebe-e263-44ef-9a37-ee9d2b6b04bf" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
