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Term Loans - Oxford Term Loans (Details) |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Jan. 04, 2021 USD ($) | Mar. 15, 2019 USD ($) advance | Jan. 31, 2021 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($)
Debt Instrument [Line Items] |  |  |  |  |
Loss from extinguishment of debts, net |  |  |  | $ 968,000 | $ 0
Term Loan Facility |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Percentage of final payment of full principal amount |  | 5.50% |  |  |
Prepayment fee percentage, year two |  | 2.00% |  |  |
Prepayment fee percentage, thereafter |  | 1.00% |  |  |
Oxford Term Loans |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Debt discount |  | $ 1,094,000 |  |  |
Debt issuance costs |  | 2,205,000 |  |  |
Interest rate, effective percentage |  |  |  |  | 11.60%
Oxford Term Loan Facility |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Repayments of long-term lines of credit | $ 76,447,000 |  | $ 76,447,000 |  |
Debt instrument fee amount comprised | 4,300,000 |  |  |  |
Debt instrument of principal amount payment | 2,800,000 |  |  |  |
Debt instrument prepayment fee amount | 1,500,000 |  |  |  |
Loss from extinguishment of debts, net | $ 1,939,000 |  |  |  |
Term Loan |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Contingent promissory note payable |  | $ 100,000,000 |  |  |
Number of advances | advance |  | 2 |  |  |
Interest rate on debt |  | 9.50% |  |  |
Period of interest only payments |  | 36 months |  |  |
Amortization period |  | 23 months |  |  |
Term Loan | LIBOR |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Basis spread on variable rate |  | 7.00% |  |  |
Term Loan | First tranche |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Contingent promissory note payable |  | $ 75,000,000 |  |  |
Term Loan | Term Loan Facility, Tranche Two |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |
Contingent promissory note payable |  | $ 25,000,000 |  |  |

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