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Income Taxes - Reconciliation of Effective Tax (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Income tax at statutory rate	$ (9,832)	$ (34,217)
State income taxes, net of Federal benefit	(1,872)	(7,232)
Revaluation of contingent royalty obligation	1,595	(513)
Meals and entertainment	230	366
Change in state tax rate	129	(242)
Officers' compensation	2,076	133
Stock compensation	(17)	616
Research and development tax credit	0	(147)
Promissory note - debt discount	120	(145)
Other, net	399	117
Valuation allowance	7,214	41,341
Total provision (benefit) for income taxes	$ 42	$ 77

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