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Consolidated Statements of Stockholders’ Equity (Deficit) - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021   55,576,988      
Beginning balance at Dec. 31, 2021 $ 81,876 $ 1 $ 504,757 $ 0 $ (422,882)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock in connection with the incentive equity plan (in shares)   683,582      
Issuance of common stock in connection with the incentive equity plan 539   539    
Stock-based compensation expense 10,833   10,833    
Net loss (74,412)        
Other comprehensive loss (337)     (337)  
Ending balance (in shares) at Dec. 31, 2022   56,260,570      
Ending balance at Dec. 31, 2022 18,499 $ 1 516,129 (337) (497,294)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock in connection with the incentive equity plan (in shares)   950,051      
Issuance of common stock in connection with the incentive equity plan 224   224    
Issuance of common stock in connection with Symatese Europe Agreement (in shares)   610,000      
Issuance of common stock in connection with Symatese Europe Agreement 5,905   5,905    
Stock-based compensation expense 16,458   16,458    
Net loss (61,685)       (61,685)
Other comprehensive loss $ (90)     (90)  
Ending balance (in shares) at Dec. 31, 2023 57,820,621 57,820,621      
Ending balance at Dec. 31, 2023 $ (20,689) $ 1 538,716 (427) (558,979)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock in connection with the incentive equity plan (in shares)   1,804,827      
Issuance of common stock in connection with the incentive equity plan 3,892   3,892    
Issuance of common stock upon follow-on offering, net of issuance costs (in shares)   3,872,100      
Issuance of common stock upon follow-on offering, net of issuance costs 50,963   50,963    
Stock-based compensation expense 22,254   22,254    
Net loss (50,420)       (50,420)
Other comprehensive loss $ (478)     (478)  
Ending balance (in shares) at Dec. 31, 2024 63,497,548 63,497,548      
Ending balance at Dec. 31, 2024 $ 5,522 $ 1 $ 615,825 $ (905) $ (609,399)