<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019db702-f7bb-791e-9065-73e5c5107555,g:be8913ad-b6dd-4591-a14e-027797b06838-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:eols="http://www.evolus.com/20260331" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.evolus.com/20260331">
  <xs:import namespace="http://fasb.org/srt/2026" schemaLocation="https://xbrl.fasb.org/srt/2026/elts/srt-2026.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2026" schemaLocation="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2026" schemaLocation="https://xbrl.sec.gov/dei/2026/dei-2026.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2026" schemaLocation="https://xbrl.sec.gov/ecd/2026/ecd-2026.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="eols-20260331_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="eols-20260331_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="eols-20260331_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="eols-20260331_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.evolus.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheets" roleURI="http://www.evolus.com/role/CondensedConsolidatedBalanceSheets">
        <link:definition>9952151 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetsParenthetical" roleURI="http://www.evolus.com/role/CondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>9952152 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" roleURI="http://www.evolus.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss">
        <link:definition>9952153 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofStockholdersEquityDeficit" roleURI="http://www.evolus.com/role/CondensedConsolidatedStatementsofStockholdersEquityDeficit">
        <link:definition>9952154 - Statement - Condensed Consolidated Statements of Stockholders&#8217; Equity (Deficit)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementsofCashFlows" roleURI="http://www.evolus.com/role/CondensedConsolidatedStatementsofCashFlows">
        <link:definition>9952155 - Statement - Condensed Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DescriptionofBusiness" roleURI="http://www.evolus.com/role/DescriptionofBusiness">
        <link:definition>9952156 - Disclosure - Description of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPolicies" roleURI="http://www.evolus.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies">
        <link:definition>9952157 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://www.evolus.com/role/FairValueMeasurements">
        <link:definition>9952158 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssets" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssets">
        <link:definition>9952159 - Disclosure - Goodwill and Intangible Assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpenses" roleURI="http://www.evolus.com/role/AccruedExpenses">
        <link:definition>9952160 - Disclosure - Accrued Expenses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyPlantandEquipment" roleURI="http://www.evolus.com/role/PropertyPlantandEquipment">
        <link:definition>9952161 - Disclosure - Property, Plant and Equipment</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebt" roleURI="http://www.evolus.com/role/LongTermDebt">
        <link:definition>9952162 - Disclosure - Long-Term Debt</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeases" roleURI="http://www.evolus.com/role/OperatingLeases">
        <link:definition>9952163 - Disclosure - Operating Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.evolus.com/role/CommitmentsandContingencies">
        <link:definition>9952164 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationandStockholdersEquity" roleURI="http://www.evolus.com/role/StockBasedCompensationandStockholdersEquity">
        <link:definition>9952165 - Disclosure - Stock-Based Compensation and Stockholders&#8217; Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MedytoxSettlementAgreements" roleURI="http://www.evolus.com/role/MedytoxSettlementAgreements">
        <link:definition>9952166 - Disclosure - Medytox Settlement Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReporting" roleURI="http://www.evolus.com/role/SegmentReporting">
        <link:definition>9952167 - Disclosure - Segment Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" roleURI="http://www.evolus.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies">
        <link:definition>9955511 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.evolus.com/role/FairValueMeasurementsTables">
        <link:definition>9955512 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsTables" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsTables">
        <link:definition>9955513 - Disclosure - Goodwill and Intangible Assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpensesTables" roleURI="http://www.evolus.com/role/AccruedExpensesTables">
        <link:definition>9955514 - Disclosure - Accrued Expenses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyPlantandEquipmentTables" roleURI="http://www.evolus.com/role/PropertyPlantandEquipmentTables">
        <link:definition>9955515 - Disclosure - Property, Plant and Equipment (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtTables" roleURI="http://www.evolus.com/role/LongTermDebtTables">
        <link:definition>9955516 - Disclosure - Long-Term Debt (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeasesTables" roleURI="http://www.evolus.com/role/OperatingLeasesTables">
        <link:definition>9955517 - Disclosure - Operating Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationandStockholdersEquityTables" roleURI="http://www.evolus.com/role/StockBasedCompensationandStockholdersEquityTables">
        <link:definition>9955518 - Disclosure - Stock-Based Compensation and Stockholders&#8217; Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingTables" roleURI="http://www.evolus.com/role/SegmentReportingTables">
        <link:definition>9955519 - Disclosure - Segment Reporting (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DescriptionofBusinessDetails" roleURI="http://www.evolus.com/role/DescriptionofBusinessDetails">
        <link:definition>9955520 - Disclosure - Description of Business (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesDetails" roleURI="http://www.evolus.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDetails">
        <link:definition>9955521 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsScheduleofFairValueofInstrumentsDetails" roleURI="http://www.evolus.com/role/FairValueMeasurementsScheduleofFairValueofInstrumentsDetails">
        <link:definition>9955522 - Disclosure - Fair Value Measurements - Schedule of Fair Value of Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsNarrativeDetails" roleURI="http://www.evolus.com/role/FairValueMeasurementsNarrativeDetails">
        <link:definition>9955523 - Disclosure - Fair Value Measurements - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsScheduleofContingentRoyaltyObligationDetails" roleURI="http://www.evolus.com/role/FairValueMeasurementsScheduleofContingentRoyaltyObligationDetails">
        <link:definition>9955524 - Disclosure - Fair Value Measurements - Schedule of Contingent Royalty Obligation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails">
        <link:definition>9955525 - Disclosure - Goodwill and Intangible Assets - Schedule of Definite and Indefinite-Lived Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails_1" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsScheduleofDefiniteandIndefiniteLivedIntangibleAssetsDetails_1">
        <link:definition>9955525 - Disclosure - Goodwill and Intangible Assets - Schedule of Definite and Indefinite-Lived Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsScheduleofFutureAmortizationExpenseDetails" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsScheduleofFutureAmortizationExpenseDetails">
        <link:definition>9955526 - Disclosure - Goodwill and Intangible Assets - Schedule of Future Amortization Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillandIntangibleAssetsNarrativeDetails" roleURI="http://www.evolus.com/role/GoodwillandIntangibleAssetsNarrativeDetails">
        <link:definition>9955527 - Disclosure - Goodwill and Intangible Assets - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpensesDetails" roleURI="http://www.evolus.com/role/AccruedExpensesDetails">
        <link:definition>9955528 - Disclosure - Accrued Expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails" roleURI="http://www.evolus.com/role/PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails">
        <link:definition>9955529 - Disclosure - Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyPlantandEquipmentNarrativeDetails" roleURI="http://www.evolus.com/role/PropertyPlantandEquipmentNarrativeDetails">
        <link:definition>9955530 - Disclosure - Property, Plant and Equipment - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtNarrativeDetails" roleURI="http://www.evolus.com/role/LongTermDebtNarrativeDetails">
        <link:definition>9955531 - Disclosure - Long-Term Debt - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtScheduleofLongTermDebtObligationsDetails" roleURI="http://www.evolus.com/role/LongTermDebtScheduleofLongTermDebtObligationsDetails">
        <link:definition>9955532 - Disclosure - Long-Term Debt - Schedule of Long-Term Debt Obligations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LongTermDebtScheduleofMaturitiesofLongTermDebtDetails" roleURI="http://www.evolus.com/role/LongTermDebtScheduleofMaturitiesofLongTermDebtDetails">
        <link:definition>9955533 - Disclosure - Long-Term Debt - Schedule of Maturities of Long-Term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeasesScheduleofComponentsofLeaseExpenseandOtherQuantitativeInformationDetails" roleURI="http://www.evolus.com/role/OperatingLeasesScheduleofComponentsofLeaseExpenseandOtherQuantitativeInformationDetails">
        <link:definition>9955534 - Disclosure - Operating Leases - Schedule of Components of Lease Expense and Other Quantitative Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeasesScheduleofWeightedAverageRemainingLeaseTermandDiscountRateDetails" roleURI="http://www.evolus.com/role/OperatingLeasesScheduleofWeightedAverageRemainingLeaseTermandDiscountRateDetails">
        <link:definition>9955535 - Disclosure - Operating Leases - Schedule of Weighted-Average Remaining Lease Term and Discount Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeasesScheduleofMaturityofOperatingLeaseLiabilitiesDetails" roleURI="http://www.evolus.com/role/OperatingLeasesScheduleofMaturityofOperatingLeaseLiabilitiesDetails">
        <link:definition>9955536 - Disclosure - Operating Leases - Schedule of Maturity of Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OperatingLeasesScheduleofMaturityofOperatingLeaseLiabilitiesDetails_1" roleURI="http://www.evolus.com/role/OperatingLeasesScheduleofMaturityofOperatingLeaseLiabilitiesDetails_1">
        <link:definition>9955536 - Disclosure - Operating Leases - Schedule of Maturity of Operating Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentandContingenciesDetails" roleURI="http://www.evolus.com/role/CommitmentandContingenciesDetails">
        <link:definition>9955537 - Disclosure - Commitment and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationandStockholdersEquityScheduleofStockbasedCompensationExpenseDetails" roleURI="http://www.evolus.com/role/StockBasedCompensationandStockholdersEquityScheduleofStockbasedCompensationExpenseDetails">
        <link:definition>9955538 - Disclosure - Stock-Based Compensation and Stockholders&#8217; Equity - Schedule of Stock-based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationandStockholdersEquityScheduleofStockbasedCompensationExpenseDetails_1" roleURI="http://www.evolus.com/role/StockBasedCompensationandStockholdersEquityScheduleofStockbasedCompensationExpenseDetails_1">
        <link:definition>9955538 - Disclosure - Stock-Based Compensation and Stockholders&#8217; Equity - Schedule of Stock-based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationandStockholdersEquityNarrativeDetails" roleURI="http://www.evolus.com/role/StockBasedCompensationandStockholdersEquityNarrativeDetails">
        <link:definition>9955539 - Disclosure - Stock-Based Compensation and Stockholders&#8217; Equity - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MedytoxSettlementAgreementsDetails" roleURI="http://www.evolus.com/role/MedytoxSettlementAgreementsDetails">
        <link:definition>9955540 - Disclosure - Medytox Settlement Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingNarrativeDetails" roleURI="http://www.evolus.com/role/SegmentReportingNarrativeDetails">
        <link:definition>9955541 - Disclosure - Segment Reporting - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingScheduleofReconciliationofRevenueandSignificantSegmentItemstoNetLossDetails" roleURI="http://www.evolus.com/role/SegmentReportingScheduleofReconciliationofRevenueandSignificantSegmentItemstoNetLossDetails">
        <link:definition>9955542 - Disclosure - Segment Reporting - Schedule of Reconciliation of Revenue and Significant Segment Items to Net Loss (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="eols_ContingentRoyaltyObligationPayabletoRelatedPartyCurrent" abstract="false" name="ContingentRoyaltyObligationPayabletoRelatedPartyCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementContingentMilestoneLiabilityCurrent" abstract="false" name="LicenseSupplyAndDistributionAgreementContingentMilestoneLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ContingentRoyaltyObligationPayableToRelatedPartyNoncurrent" abstract="false" name="ContingentRoyaltyObligationPayableToRelatedPartyNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementContingentMilestoneLiabilityNoncurrent" abstract="false" name="LicenseSupplyAndDistributionAgreementContingentMilestoneLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_StockIssuedDuringPeriodSharesIncentiveEquityPlan" abstract="false" name="StockIssuedDuringPeriodSharesIncentiveEquityPlan" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_StockIssuedDuringPeriodValueIncentiveEquityPlan" abstract="false" name="StockIssuedDuringPeriodValueIncentiveEquityPlan" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_AccountsReceivableAndInventoryCreditLossExpenseReversal" abstract="false" name="AccountsReceivableAndInventoryCreditLossExpenseReversal" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_OtherAdjustmentsOperatingActivity" abstract="false" name="OtherAdjustmentsOperatingActivity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PaymentsOfContingentRoyaltyObligation" abstract="false" name="PaymentsOfContingentRoyaltyObligation" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ProceedsFromPaymentsForIssuanceOfCommonStockInConnectionWithEquityIncentivePlan" abstract="false" name="ProceedsFromPaymentsForIssuanceOfCommonStockInConnectionWithEquityIncentivePlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_SymateseEuropeAgreementMember" abstract="true" name="SymateseEuropeAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_SymateseU.S.AgreementMember" abstract="true" name="SymateseU.S.AgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementMember" abstract="true" name="ARLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementTrancheOneMember" abstract="true" name="ARLoanAgreementTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementTrancheTwoMember" abstract="true" name="ARLoanAgreementTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementTrancheThreeMember" abstract="true" name="ARLoanAgreementTrancheThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_LoanAgreementMember" abstract="true" name="LoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ATMSalesAgreementMember" abstract="true" name="ATMSalesAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRegulatoryApprovalNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementRegulatoryApprovalNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementExpectedRegulatoryApprovalNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementExpectedRegulatoryApprovalNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LineOfCreditFacilityAccordionFeatureMaximumLimit" abstract="false" name="LineOfCreditFacilityAccordionFeatureMaximumLimit" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LineOfCreditFacilityAccordionFeatureElectableIncrementAmount" abstract="false" name="LineOfCreditFacilityAccordionFeatureElectableIncrementAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LineOfCreditFacilityMinimumUtilizationThresholdAmount" abstract="false" name="LineOfCreditFacilityMinimumUtilizationThresholdAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentNumberOfTranches" abstract="false" name="DebtInstrumentNumberOfTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LineOfCreditFacilityMaximumBorrowingCapacityOption" abstract="false" name="LineOfCreditFacilityMaximumBorrowingCapacityOption" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_SaleOfStockMaximumConsiderationReceivable" abstract="false" name="SaleOfStockMaximumConsiderationReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DistributionRightsEvolysseNasolabialFoldProductMember" abstract="true" name="DistributionRightsEvolysseNasolabialFoldProductMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_DistributionRightsEvolysseProductsMember" abstract="true" name="DistributionRightsEvolysseProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_MilestoneAxis" abstract="true" name="MilestoneAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="eols_MilestoneDomain" abstract="true" name="MilestoneDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_FirstMilestonePaymentMember" abstract="true" name="FirstMilestonePaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_SecondMilestonePaymentMember" abstract="true" name="SecondMilestonePaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EvolusIncMember" abstract="true" name="EvolusIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_SCHAEONLLCMember" abstract="true" name="SCHAEONLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PerformanceRestrictedStockUnitsPRSUMember" abstract="true" name="PerformanceRestrictedStockUnitsPRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRightToCommercializeAndDistributeNumberOfProductCandidates" abstract="false" name="LicenseSupplyAndDistributionAgreementRightToCommercializeAndDistributeNumberOfProductCandidates" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_AccountsReceivableCreditCardTransactionConvertedToCashPeriod" abstract="false" name="AccountsReceivableCreditCardTransactionConvertedToCashPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementMinimumMilestonePayment" abstract="false" name="LicenseSupplyAndDistributionAgreementMinimumMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementInitialPaymentInConnectionWithAgreement" abstract="false" name="LicenseSupplyAndDistributionAgreementInitialPaymentInConnectionWithAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementInitialPaymentDuePeriod" abstract="false" name="LicenseSupplyAndDistributionAgreementInitialPaymentDuePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualPaymentYearOne" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualPaymentYearOne" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualPaymentYearTwo" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualPaymentYearTwo" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualPaymentYearThree" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualPaymentYearThree" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualPaymentYearFour" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualPaymentYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualPaymentTriggeredRegulatoryApprovalNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualPaymentTriggeredRegulatoryApprovalNumberOfProducts" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementUpfrontPaymentInProcessResearchAndDevelopmentExpense" abstract="false" name="LicenseSupplyAndDistributionAgreementUpfrontPaymentInProcessResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRegulatoryApprovalNotAchievedNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementRegulatoryApprovalNotAchievedNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualMilestonePayment" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementInitialTerm" abstract="false" name="LicenseSupplyAndDistributionAgreementInitialTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRenewalTerm" abstract="false" name="LicenseSupplyAndDistributionAgreementRenewalTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfProductCandidates" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfProductCandidates" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfCountriesUseAestheticsAndDermatologicalFields" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfCountriesUseAestheticsAndDermatologicalFields" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_StockIssuedDuringPeriodSharesIssuedForLicenseSupplyAndDistributionAgreement" abstract="false" name="StockIssuedDuringPeriodSharesIssuedForLicenseSupplyAndDistributionAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfMilestonePayment" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfMilestonePayment" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualNetRevenue" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualNetRevenue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_NonCashInResearchAndDevelopmentInProcessExpenses" abstract="false" name="NonCashInResearchAndDevelopmentInProcessExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementPendingRegulatoryApprovalNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementPendingRegulatoryApprovalNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementMilestonePaymentPayablePeriod" abstract="false" name="LicenseSupplyAndDistributionAgreementMilestonePaymentPayablePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementLiabilityNoncurrent" abstract="false" name="LicenseSupplyAndDistributionAgreementLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementIntangibleAsset" abstract="false" name="LicenseSupplyAndDistributionAgreementIntangibleAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_RelatedPartyTransactionPeriodOfTerminationOfFirstCommercialSale" abstract="false" name="RelatedPartyTransactionPeriodOfTerminationOfFirstCommercialSale" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_RebatesAndCouponsCreditsAndPayments" abstract="false" name="RebatesAndCouponsCreditsAndPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PaymentsForProvisionsForAccruedVolumeBasedRebateAndCouponLiability" abstract="false" name="PaymentsForProvisionsForAccruedVolumeBasedRebateAndCouponLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_AccountsReceivableAllowanceForCreditLossWriteOffRecoveryNet" abstract="false" name="AccountsReceivableAllowanceForCreditLossWriteOffRecoveryNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ContingentRoyaltyObligationMember" abstract="true" name="ContingentRoyaltyObligationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PharmakonTermLoansMember" abstract="true" name="PharmakonTermLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_IntangibleAssetsGrossIncludingGoodwill" abstract="false" name="IntangibleAssetsGrossIncludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_MarketingFixturesMember" abstract="true" name="MarketingFixturesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementAmountsBorrowedUnderPriorTermLoanMember" abstract="true" name="ARLoanAgreementAmountsBorrowedUnderPriorTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementIncrementalBorrowingsMember" abstract="true" name="ARLoanAgreementIncrementalBorrowingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementTrancheTwoAndThreeMember" abstract="true" name="ARLoanAgreementTrancheTwoAndThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PriorPharmakonLoanAgreementMember" abstract="true" name="PriorPharmakonLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_DebtInstrumentBasisSpreadOnVariableRateFloor" abstract="false" name="DebtInstrumentBasisSpreadOnVariableRateFloor" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_LineOfCreditFacilityClosingFeePercentage" abstract="false" name="LineOfCreditFacilityClosingFeePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentPrepaymentFeePercentageYearOne" abstract="false" name="DebtInstrumentPrepaymentFeePercentageYearOne" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentPrepaymentFeePercentageYearTwo" abstract="false" name="DebtInstrumentPrepaymentFeePercentageYearTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentPrepaymentFeePercentageAfterTwo" abstract="false" name="DebtInstrumentPrepaymentFeePercentageAfterTwo" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentLenderFeesAndDebtIssuanceCostsNet" abstract="false" name="DebtInstrumentLenderFeesAndDebtIssuanceCostsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ProceedsFromSecuredLinesOfCreditNetOfDiscountsAndFees" abstract="false" name="ProceedsFromSecuredLinesOfCreditNetOfDiscountsAndFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LineOfCreditFacilityMinimumBorrowingCapacity" abstract="false" name="LineOfCreditFacilityMinimumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentAdditionalConsiderationOnPrincipalDrawnPercentage" abstract="false" name="DebtInstrumentAdditionalConsiderationOnPrincipalDrawnPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentExitConsiderationMultiplier" abstract="false" name="DebtInstrumentExitConsiderationMultiplier" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentDirectLenderFeesAndModificationCosts" abstract="false" name="DebtInstrumentDirectLenderFeesAndModificationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentDirectLenderFees" abstract="false" name="DebtInstrumentDirectLenderFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentModificationCosts" abstract="false" name="DebtInstrumentModificationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentExitConsideration" abstract="false" name="DebtInstrumentExitConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LongTermDebtMaturityAfterYearFour" abstract="false" name="LongTermDebtMaturityAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PaymentsForInventory" abstract="false" name="PaymentsForInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ServiceBasedStockOptionsAndRestrictedStockUnitsMember" abstract="true" name="ServiceBasedStockOptionsAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PerformanceRestrictedStockUnitsPRSUAndMarketBasedRestrictedStockUnitsMBRSUMember" abstract="true" name="PerformanceRestrictedStockUnitsPRSUAndMarketBasedRestrictedStockUnitsMBRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_MarketBasedRestrictedStockUnitsMBRSUMember" abstract="true" name="MarketBasedRestrictedStockUnitsMBRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ServiceBasedRestrictedStockUnitsMember" abstract="true" name="ServiceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_A2024EmployeeStockPurchasePlanMember" abstract="true" name="A2024EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_A2023InducementIncentivePlanMember" abstract="true" name="A2023InducementIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalShareIncreaseAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalShareIncreaseAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_SaleOfStockCommissionPaymentUponGrossProceedsPercentage" abstract="false" name="SaleOfStockCommissionPaymentUponGrossProceedsPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsWeightedAverageExpectedTerm" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsWeightedAverageExpectedTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_SettlementAndLicenseAgreementAccruedRoyalties" abstract="false" name="SettlementAndLicenseAgreementAccruedRoyalties" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_JeuveauMember" abstract="true" name="JeuveauMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EvolysseMember" abstract="true" name="EvolysseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EliminationsAndReconcilingItemsMember" abstract="true" name="EliminationsAndReconcilingItemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
