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Document and Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2021
Mar. 04, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Trading Symbol DSGN    
Entity Registrant Name Design Therapeutics, Inc.    
Entity Central Index Key 0001807120    
Current Fiscal Year End Date --12-31    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Shell Company false    
Entity Small Business true    
Entity Emerging Growth Company true    
Entity Ex Transition Period true    
Entity Common Stock, Shares Outstanding   55,700,156  
Title of 12(b) Security Common Stock, $0.0001 par value per share    
Entity File Number 001-40288    
Security Exchange Name NASDAQ    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 82-3929248    
Entity Address, Address Line One 6005 Hidden Valley Road    
Entity Address, Address Line Two Suite 110    
Entity Address, City or Town Carlsbad    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92011    
City Area Code 858    
Local Phone Number 293-4900    
Document Transition Report false    
Document Annual Report true    
Entity Voluntary Filers No    
Entity Well-known Seasoned Issuer No    
Entity Public Float     $ 480,984,316
Auditor Firm ID 42    
Auditor Name Ernst & Young LLP    
Auditor Location San Diego, California    
ICFR Auditor Attestation Flag false    
Documents Incorporated by Reference Portions of the registrant's definitive proxy statement for its 2022 Annual Meeting of Stockholders, which the registrant intends to file pursuant to Regulation 14A with the Securities and Exchange Commission no later than 120 days after the registrant's fiscal year ended December 31, 2021, are incorporated by reference into Part III of this Annual Report on Form 10-K