    <SEC-DOCUMENT>0000950170-23-012726-index.html : 20230413
    <SEC-HEADER>0000950170-23-012726.hdr.sgml : 20230413
    <ACCEPTANCE-DATETIME>20230413164051
    ACCESSION NUMBER:		0000950170-23-012726
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230413
    DATE AS OF CHANGE:		20230413
    EFFECTIVENESS DATE:		20230413

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Design Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001807120
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				823929248
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40288
    		FILM NUMBER:		23818841

    	BUSINESS ADDRESS:
    		STREET 1:		6005 HIDDEN VALLEY ROAD
    		STREET 2:		SUITE 110
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92011
    		BUSINESS PHONE:		858-293-4900

    	MAIL ADDRESS:
    		STREET 1:		6005 HIDDEN VALLEY ROAD
    		STREET 2:		SUITE 110
    		CITY:			CARLSBAD
    		STATE:			CA
    		ZIP:			92011
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>dsgn-ars-20221231.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: dsgn-ars-20221231.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>