Research and Collaboration Arrangements - CFF - Additional Information (Details) $ in Thousands	1 Months Ended	12 Months Ended
Sep. 30, 2016 USD ($) Installment	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue recognized		$ 18,038	$ 13,363
Estimated fair value of derivative liability		200	100
CFF
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative arrangement total amount of award	$ 3,500
Collaborative arrangement achieved milestones		1,800	1,300
Expected payments percentage to equal actual award received	600.00%
Number of installments to pay actual award \| Installment	3
Actual award payment period upon first commercial sale of product	4 years
Royalties percentage on actual award received	600.00%
Continuous period where the Company ceases to develop or commercialize any product	180 days
Collaborative arrangement transaction price adjustment		500
Revenue recognized		100	100
Deferred revenue		1,400	1,100
Accounts receivable		0	400
Remaining performance obligations		$ 1,400	$ 1,100
CFF \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Future sales-based milestone payments percentage	300.00%

Actual award payment period upon first commercial sale of product.

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Collaborative arrangement achieved milestones.

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Collaborative arrangement transaction price adjustment.

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Collaborative arrangements future sales based milestone payments percentage.

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Collaborative arrangements royalties percentage on actual award received.

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Continuous period where the Company ceases to develop or commercialize any product.

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Expected payments percentage to equal actual award received.

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Number of installments to pay actual award.

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Amount, after allowance for credit loss, of right to consideration in exchange for good or service transferred to customer when right to consideration is unconditional.

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Amount of deferred income and obligation to transfer product and service to customer for which consideration has been received or is receivable.

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Fair value, before effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset. Includes liabilities elected not to be offset. Excludes liabilities not subject to a master netting arrangement.

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Amount of revenue from collaborative arrangement. Excludes revenue from contract with customer under Topic 606.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Amount of transaction price allocated to performance obligation that has not been recognized as revenue.

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