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Commitments and Contingencies - Additional Information (Details) € in Thousands |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 135 Months Ended
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Mar. 31, 2021 ft² | Apr. 05, 2019 EUR (€) Installment | Jan. 31, 2022 USD ($) | Oct. 31, 2020 USD ($) | Aug. 31, 2019 EUR (€) | Jul. 31, 2019 USD ($) | Apr. 30, 2019 EUR (€) | Dec. 31, 2014 USD ($) LicensedProduct | Jan. 31, 2014 USD ($) | Sep. 30, 2013 USD ($) | Jul. 31, 2011 USD ($) | Dec. 31, 2010 USD ($) | Nov. 30, 2009 | Mar. 31, 2022 USD ($) | Mar. 31, 2021 USD ($) ft² | Dec. 31, 2021 USD ($) | Dec. 31, 2017 EUR (€) | Mar. 31, 2022 USD ($)
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Area of space leased | ft² | 4,516 |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,516 |  |  |
Lease commencement date | May 01, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional square feet of laboratory space | ft² | 1,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,000 |  |  |
Additional leased space commencement date | Jun. 15, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease termination date | Jul. 31, 2023 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lease existence of option to extend | true |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating lease, option to extend term | 12 months |  |  |  |  |  |  |  |  |  |  |  |  |  | 12 months |  |  |
Research and development expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 8,276,000 | $ 4,185,000 |  |  |
Biologic Materials License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
One time non refundable license issuance fee |  |  |  |  |  |  |  |  |  |  |  | $ 20,000.00 |  |  |  |  |  |
Milestone payments or royalties |  |  |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |
National Institute of Health |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestone payments |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000 |  |  |  | $ 400,000
License issue royalty fee |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |
Sales milestone payments |  |  |  |  |  |  |  |  |  | 600,000 |  |  |  |  |  |  |  |
Development and regulatory milestone payments |  |  |  |  |  |  |  |  |  | $ 700,000 |  |  |  |  |  |  |  |
Patent licensing reimbursement fees |  |  |  |  |  |  |  |  |  |  |  |  |  | 30,000.00 |  |  |  |
Expenses for patent licensing fees |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  |  |
Royalty Bearing Patent License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  |  |
License agreement term |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |
Royalty Bearing Patent License Agreement | IND Filings |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payments | € |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | € 10 |
Clearside |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  |  |
Upfront payment |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |
Royalties on net sales |  |  |  |  |  | 20.00% |  |  |  |  |  |  |  |  |  |  |  |
License agreement expiration period |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |
Clearside | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestones payment |  |  |  |  |  | $ 21,000,000.0 |  |  |  |  |  |  |  |  |  |  |  |
LI-COR, Inc. | Exclusive License And Supply Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
One-time upfront license issuance fee |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |
Research and development expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  |  |
License agreement term |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |
LI-COR, Inc. | Exclusive License And Supply Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestone payments |  |  |  |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |
LI-COR, Inc. | 2014 Non- Exclusive Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License issue fee |  |  |  |  |  |  |  | $ 30,000.00 |  |  |  |  |  |  |  |  |  |
Non-refundable, Non- creditable fee |  |  |  |  |  |  |  | 30,000.00 |  |  |  |  |  |  |  |  |  |
LI-COR, Inc. | 2014 Non- Exclusive Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate milestone payments |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |
Payments for development and commercial milestones |  |  |  |  |  |  |  | $ 400,000 |  |  |  |  |  |  |  |  |  |
Life Technologies |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of licensed products | LicensedProduct |  |  |  |  |  |  |  | 5 |  |  |  |  |  |  |  |  |  |
Initial license fee |  |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |
Annual development fee |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |
Non-refundable, Non- creditable fee |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |
Change of control fees |  |  |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |  |
One time perpetual license agreement fee |  |  | $ 50,000.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000.00 | 20,000.00 |  |  |
Dr. John Schiller | Collaboration Research and Development Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Annual development fee |  |  |  |  |  |  |  |  |  |  | $ 30,000.00 |  |  |  |  |  |  |
Expenses |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | $ 0 |  |  |
Agreement term |  |  |  |  |  |  |  |  |  |  | 2 years |  |  |  |  |  |  |
First payment due |  |  |  |  |  |  |  |  |  |  | 30 days |  |  |  |  |  |  |
Subsequent payments due |  |  |  |  |  |  |  |  |  |  | 30 days |  |  |  |  |  |  |
Aggregate research collaboration fees |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 |  | $ 30,000.00 |  | $ 400,000
Required amendment payment |  |  |  | $ 40,000.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Required amendment payment due period |  |  |  | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Dr. John Schiller | Collaboration Research and Development Agreement | 10th Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Required amendment payment |  |  |  | $ 30,000.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Required amendment payment due period |  |  |  | 30 days |  |  |  |  |  |  |  |  |  |  |  |  |  |
Laser System |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase agreement, commitments payable in each installment | € |  | € 200 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase agreement, number of payment installments | Installment |  | 3 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Laser System | Installment One |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase agreement, installment amount paid | € |  |  |  |  |  |  | € 200 |  |  |  |  |  |  |  |  |  |  |
Laser System | Installment Two |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Lessee Lease Description [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Purchase agreement, installment amount paid | € |  |  |  |  | € 200 |  |  |  |  |  |  |  |  |  |  |  |  |

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