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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2025
Income Tax Disclosure [Abstract] |
Schedule of loss before income taxes | For the years ended December 31, 2025 and 2024, the loss before income taxes consisted of the following (in thousands):
|  | 2025 |  |  | 2024 |
Domestic |  | $ | (106,911 | ) |  | $ | (86,185 | )
Foreign |  |  | 828 |  |  |  | (622 | )
Total |  | $ | (106,083 | ) |  | $ | (86,807 | )
Schedule of Income Tax Provision | The Company's income tax provision, net consisted of the following (in thousands):
|  | 2025 |  |  | 2024 |
Components of income tax provision: |  |  |  |  |  |
Current: |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |
State |  |  | 78 |  |  |  | 112 |
Foreign |  |  | 30 |  |  |  | — |
Total Current |  |  | 108 |  |  |  | 112 |
Deferred: |  |  |  |  |  |
Federal |  |  | — |  |  |  | — |
State |  |  | — |  |  |  | — |
Foreign |  |  | — |  |  |  | — |
Total Deferred |  |  | — |  |  |  | — |
Total Income Tax Provision |  | $ | 108 |  |  | $ | 112 |
Summary of Reconciliation of Federal Statutory Income Tax Rate to Company's Effective Tax Rate | A reconciliation of the federal statutory income tax rate to the Company’s effective tax rate as of December 31, 2025 and 2024 is as follows (in thousands):
|  | 2025 |  |  | 2024 |
Income tax provision at statutory rate |  | $ | (22,278 | ) |  | 21.0 | % |  | $ | (18,229 | ) |  | 21.0 | %
State and local taxes, net of federal benefit |  |  | 78 |  |  | (0.1 | )% |  |  | 112 |  |  | (0.1 | )%
Foreign tax effects |  |  |  |  |  |  |  |  |  |
Other foreign jurisdictions |  |  | (144 | ) |  | 0.1 | % |  |  | 131 |  |  | (0.2 | )%
Tax credits |  |  |  |  |  |  |  |  |  |
Research and development credits |  |  | 2,729 |  |  | (2.5 | )% |  |  | (3,088 | ) |  | 3.6 | %
Orphan drug credits |  |  | (20,441 | ) |  | 19.3 | % |  |  | — |  |  | — | %
Nontaxable or nondeductible items |  |  | 1,786 |  |  | (1.7 | )% |  |  | 1,184 |  |  | (1.4 | )%
Changes in valuation allowance |  |  | 35,097 |  |  | (33.1 | )% |  |  | 19,630 |  |  | (22.6 | )%
Other items |  |  |  |  |  |  |  |  |  |
NOL adjustment - Section 382 study |  |  | 3,157 |  |  | (2.9 | )% |  |  | — |  |  | — | %
Other |  |  | 124 |  |  | (0.1 | )% |  |  | 372 |  |  | (0.3 | )%
Total |  | $ | 108 |  |  | (0.0 | )% |  | $ | 112 |  |  | 0.0 | %
Summary of Deferred Tax Assets (Liabilities) | Temporary differences that give rise to significant deferred tax assets (liabilities) as of December 31, 2025 and 2024 are as follows (in thousands):
|  | 2025 |  |  | 2024 |
Deferred tax assets: |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 84,238 |  |  | $ | 55,826 |
Stock-based compensation expense |  |  | 3,009 |  |  |  | 2,450 |
Capitalized research and development expenses |  |  | 24,440 |  |  |  | 32,422 |
Tax credit carryforwards |  |  | 31,980 |  |  |  | 13,582 |
Accrued expenses and other current liabilities |  |  | 1,368 |  |  |  | 1,025 |
Lease liability |  |  | 4,520 |  |  |  | 4,903 |
Other |  |  | 993 |  |  |  | 938 |
Total deferred tax assets |  |  | 150,548 |  |  |  | 111,146 |
Deferred tax liabilities: |  |  |  |  |  |
Right-of-use assets |  |  | (4,117 | ) |  |  | (4,540 | )
Depreciable assets |  |  | (266 | ) |  |  | (312 | )
Prepaid expenses and other current assets |  |  | (433 | ) |  |  | (443 | )
Valuation allowance |  |  | (145,732 | ) |  |  | (105,851 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |

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