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Income Taxes - Summary of Reconciliation of Federal Statutory Income Tax Rate to Company's Effective Tax Rate (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract] |  |
Income tax provision at statutory rate | $ (22,278) | $ (18,229)
State and local taxes, net of federal benefit | 78 | 112
Research and development credits | 2,729 | (3,088)
Orphan drug credits | (20,441) |
Nontaxable or nondeductible items | 1,786 | 1,184
Changes in valuation allowance | 35,097 | 19,630
NOL adjustment - Section 382 study | 3,157 |
Other | 124 | 372
Total Income Tax Provision | $ 108 | $ 112
Effective Income Tax Rate Reconciliation, Percent [Abstract] |  |
Income tax provision at statutory rate | 21.00% | 21.00%
State and local taxes, net of federal benefit | (0.10%) | (0.10%)
Research and development credits | (2.50%) | 3.60%
Orphan drug credits | 19.30% |
Nontaxable or nondeductible items | (1.70%) | (1.40%)
Changes in valuation allowance | (33.10%) | (22.60%)
NOL adjustment - Section 382 study | (2.90%) |
Other | (0.10%) | (0.30%)
Total | (0.00%) | 0.00%
Other foreign jurisdictions |  |
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract] |  |
Foreign tax effects | $ (144) | $ 131
Effective Income Tax Rate Reconciliation, Percent [Abstract] |  |
Foreign tax effects | 0.10% | (0.20%)

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