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Commitments and Contingencies - Additional Information (Details)
€ in Thousands
 1 Months Ended 12 Months Ended
May 16, 2022
USD ($)
Jan. 14, 2014
Mar. 30, 2026
USD ($)
Sep. 30, 2024
USD ($)
Sep. 30, 2022
USD ($)
Jan. 31, 2022
USD ($)
Jul. 31, 2019
USD ($)
Dec. 31, 2014
USD ($)
LicensedProduct
Sep. 30, 2013
USD ($)
Jul. 31, 2011
USD ($)
Nov. 30, 2009
EUR (€)
Dec. 31, 2025
USD ($)
OperatingLease
Dec. 31, 2024
USD ($)
Jan. 31, 2014
USD ($)
Lessee Lease Description [Line Items]                            
Estimated payments due                       $ 24,346,000    
Operating lease liabilities                       17,377,000    
Research and development expenses                       90,300,000 $ 73,302,000  
National Institute of Health                            
Lessee Lease Description [Line Items]                            
License issue royalty fee                 $ 100,000          
Sales milestone payments                 600,000          
Development and regulatory milestone payments                 $ 700,000          
Patent licensing reimbursement fees                       30,000.00    
Expenses for patent licensing fees                       40,000.00 30,000.00  
Royalty Bearing Patent License Agreement                            
Lessee Lease Description [Line Items]                            
Expenses                       0 100,000  
License agreement term                     10 years      
Royalty Bearing Patent License Agreement | IND Filings                            
Lessee Lease Description [Line Items]                            
Potential milestone payments | €                     € 10      
Clearside                            
Lessee Lease Description [Line Items]                            
Expenses                       0 0  
Upfront payment             $ 100,000              
Royalties on net sales             20.00%              
License agreement expiration period             10 years              
Clearside | Subsequent Event                            
Lessee Lease Description [Line Items]                            
Upfront payment     $ 1,000,000                      
One-time payment     $ 1,500,000                      
Clearside | Maximum                            
Lessee Lease Description [Line Items]                            
Aggregate milestones payment             $ 21,000,000              
LI-COR, Inc. | 2014 Exclusive Agreement                            
Lessee Lease Description [Line Items]                            
One-time upfront license issuance fee                           $ 100,000
Research and development expenses                       0 0  
License agreement expiration period   10 years                        
LI-COR, Inc. | 2014 Exclusive Agreement | Maximum                            
Lessee Lease Description [Line Items]                            
Aggregate milestone payments                           $ 200,000
LI-COR, Inc. | 2014 Non- Exclusive Agreement                            
Lessee Lease Description [Line Items]                            
License issue fee               $ 30,000.00            
Milestone payments                       0 0  
LI-COR, Inc. | 2014 Non- Exclusive Agreement | Maximum                            
Lessee Lease Description [Line Items]                            
Payments for development and commercial milestones               400,000            
Life Technologies                            
Lessee Lease Description [Line Items]                            
Non-refundable, Non- creditable fee               $ 300,000            
Milestone payments                       0 0  
Number of licensed products | LicensedProduct               5            
Initial license fee               $ 100,000            
Annual development fee               100,000            
Initial license fee for first licensed product         $ 400,000                  
Initial license fee for additional licensed product         500,000                  
Payment for sublicense         200,000                  
Payment for use of cell line document package         30,000.00                  
Change of control fees         $ 500,000     200,000            
One time perpetual license agreement fee           $ 50,000.00                
Expense related to agreement including sublicense                       0 500,000  
Dr. John Schiller | 2014 Non- Exclusive Agreement                            
Lessee Lease Description [Line Items]                            
Required amendment payment       $ 60,000.00                    
Required amendment payment due period       30 days                    
Dr. John Schiller | Collaboration Research and Development Agreement                            
Lessee Lease Description [Line Items]                            
Annual development fee                   $ 30,000.00        
Agreement term                   2 years        
First payment due                   30 days        
Subsequent payments due                   30 days        
Research collaboration fees                       0 0  
Dr. John Schiller | Collaboration Research and Development Agreement | 10th Anniversary                            
Lessee Lease Description [Line Items]                            
Required amendment payment       $ 50,000.00                    
Required amendment payment due period       30 days                    
Dr. John Schiller | Collaboration Research and Development Agreement | Ninth Amendment                            
Lessee Lease Description [Line Items]                            
Expenses                       $ 50,000.00 100,000  
Rakuten | 2014 Non- Exclusive Agreement                            
Lessee Lease Description [Line Items]                            
License issue fee               30,000.00            
Rakuten | 2014 Non- Exclusive Agreement | Maximum                            
Lessee Lease Description [Line Items]                            
License issue fee               $ 300,000            
Office and Laboratory Facility                            
Lessee Lease Description [Line Items]                            
Number of operating lease | OperatingLease                       1    
Estimated payments due $ 35,200,000                          
Lease commencement date Aug. 01, 2022                          
Operating lease, option to extend term 7 years                          
Letters of credit $ 800,000                          
Maximum reimbursement cost $ 500,000                          
Incurred of expenses related to expansion                         $ 500,000