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Income Taxes - Additional Information (Details) - USD ($)
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Operating Loss Carryforwards [Line Items]    
Tax provision $ 108,000 $ 112,000
Income taxes paid 100,000 100,000
Deferred tax assets, valuation allowance 145,732,000 105,851,000
Increase in valuation allowance 39,900,000  
Unrecognized tax benefits 0 0
Gross deferred tax assets 150,548,000 $ 111,146,000
Federal    
Operating Loss Carryforwards [Line Items]    
Accumulated net operating loss carryforwards 318,900,000  
Operating loss carryforwards not subject to expiration $ 286,500,000  
Federal | Earliest Tax Year    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforwards begin to expire period 2034  
Federal | Latest Tax Year    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforwards begin to expire period 2037  
Federal | 2034 Through 2037    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforwards subject to expiration $ 32,400,000  
Federal | Research and Development    
Operating Loss Carryforwards [Line Items]    
Tax Credit Carryforward $ 8,500,000  
Tax credit carryforwards begin to expire period 2038  
Federal | Orphan Drug Credits    
Operating Loss Carryforwards [Line Items]    
Tax Credit Carryforward $ 20,400,000  
Tax credit carryforwards begin to expire period 2039  
Increase in credit carryforwards $ 12,100,000  
State    
Operating Loss Carryforwards [Line Items]    
Accumulated net operating loss carryforwards 274,400,000  
Operating loss carryforwards not subject to expiration $ 2,200,000  
Operating loss carryforwards begin to expire period 2030  
State | Research and Development    
Operating Loss Carryforwards [Line Items]    
Tax Credit Carryforward $ 3,800,000  
Tax credit carryforwards begin to expire period 2034  
State | Orphan Drug Credits    
Operating Loss Carryforwards [Line Items]    
Increase in credit carryforwards $ 200,000