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Income Taxes - Summary of Reconciliation of Federal Statutory Income Tax Rate to Company's Effective Tax Rate (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]    
Income tax provision at statutory rate $ (22,278) $ (18,229)
State and local taxes, net of federal benefit 78 112
Research and development credits 2,729 (3,088)
Orphan drug credits (20,441)  
Nontaxable or nondeductible items 1,786 1,184
Changes in valuation allowance 35,097 19,630
NOL adjustment - Section 382 study 3,157  
Other 124 372
Total Income Tax Provision $ 108 $ 112
Effective Income Tax Rate Reconciliation, Percent [Abstract]    
Income tax provision at statutory rate 21.00% 21.00%
State and local taxes, net of federal benefit (0.10%) (0.10%)
Research and development credits (2.50%) 3.60%
Orphan drug credits 19.30%  
Nontaxable or nondeductible items (1.70%) (1.40%)
Changes in valuation allowance (33.10%) (22.60%)
NOL adjustment - Section 382 study (2.90%)  
Other (0.10%) (0.30%)
Total (0.00%) 0.00%
Other foreign jurisdictions    
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]    
Foreign tax effects $ (144) $ 131
Effective Income Tax Rate Reconciliation, Percent [Abstract]    
Foreign tax effects 0.10% (0.20%)