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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Cash flows from operating activities:    
Net loss $ (106,191) $ (86,919)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 1,129 1,223
Accretion income on marketable securities (1,546) (4,659)
Other non-cash items 27 (5)
Stock-based compensation expense 14,317 11,722
Non-cash lease expense 1,551 1,475
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 4,031 (3,904)
Other long-term assets 47 (9)
Accounts payable (846) 482
Accrued expenses and other liabilities 4,131 1,577
Operating lease liabilities (1,392) (788)
Net cash used in operating activities (84,742) (79,805)
Cash flows from investing activities:    
Purchases of property and equipment (447) (1,253)
Purchases of marketable securities (83,958) (59,103)
Proceeds from sale of marketable securities   (5)
Maturities of marketable securities 120,000 129,182
Net cash provided by investing activities 35,595 68,821
Cash flows from financing activities:    
Proceeds from exercise of stock options 1,010 1,418
Proceeds from issuance of common stock from follow-on offering, net of issuance costs 46,517 0
Proceeds from issuance of pre-funded warrants from follow-on offering, net of issuance costs 14,156 0
Proceeds from issuance of common stock warrants from follow-on offering, net of issuance costs 9,254 0
Proceeds from issuance of common stock under ATM facility, net of issuance costs 6,054 0
Proceeds from ESPP purchases 164 177
Net cash provided by financing activities 77,155 1,595
Net increase (decrease) in cash, cash equivalents and restricted cash 28,008 (9,389)
Effect of exchange rate changes on cash and cash equivalents (186) 0
Cash, cash equivalents and restricted cash at beginning of period 32,461 41,850
Cash, cash equivalents and restricted cash at end of period 60,283 32,461
Supplemental disclosure of cash flow information:    
Purchases of property and equipment in accounts payable and accrued expenses and other liabilities $ 91 $ 35