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Segment Reporting - Summary of Significant Segment Expenses (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Segment Reporting Information [Line Items]    
Research and development expenses $ (90,300) $ (73,302)
General and administrative [1] (22,491) (22,814)
Other Segment Items [2] 6,599 9,197
Net loss (106,191) (86,919)
Clinical, Preclinical, and R&D Operations    
Segment Reporting Information [Line Items]    
Research and development expenses [1] (63,154) (49,550)
Chemistry, Manufacturing and Controls    
Segment Reporting Information [Line Items]    
Research and development expenses [1] $ (27,145) $ (23,752)
[1] Includes depreciation expense directly allocated to respective activities
[2] Other segment items primarily include interest and accretion income, realized gains and losses, and income taxes