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Consolidated Statements of Operations (USD $)
In Thousands, except Share data, unless otherwise specified
 12 Months Ended 281 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2011
Costs and expenses        
General and administrative expenses $ 21,283 $ 13,187 $ 3,899 $ 61,148
Research and development costs 25,173 17,556 9,637 81,764
Total costs and expenses 46,456 30,743 13,536 142,912
Operating loss (46,456) (30,743) (13,536) (142,912)
Change in fair value of warrant liability, net 15,566 (15,951) (8,568) (5,133)
Interest income 5 10 74 2,877
Other expense and interest expense 0 0 (27) (274)
Net loss $ (30,885) $ (46,684) $ (22,057) $ (145,442)
Common share data:        
Basic and diluted loss per share (in dollars per share) $ (0.68) $ (1.20) $ (0.82)  
Weighted average number of basic and diluted common shares outstanding (in shares) 45,236,921 38,991,481 27,072,556